GSM239969[Accession] - GEO DataSets

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Items: 4

Select item 2000094471.

Alpha2-6-linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation In Vivo

(Submitter supplied) Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have prognostic significance in human cancer. A classic but unexplained example is enhanced α2-6-sialylation on N-glycans, resulting from over-expression of the Golgi enzyme β-galactoside:α2-6-sialyltransferase (ST6Gal-I). Previous data supporting a role for the resulting Siaα2-3Galβ1-4GlcNAc (Sia6LacNAc) structure in tumor biology were based on in vitro studies in transfected carcinoma cells, in which increased Sia6LacNAc on β1-integrins enhanced their binding to ligands, and stimulated cell motility. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3151
Platform:: GPL1261
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE9447

ID:: 200009447

Select item 31512.

Beta-galactoside alpha-2,6-sialyltransferase deficient mammary tumors

Analysis of mammary tumors from animals lacking beta-galactoside alpha-2,6-sialyltransferase (ST6Gal-I). Increased ST6Gal-I expression is reported in several carcinomas including breast carcinoma. Results provide insight into the role of ST6Gal-I in tumor progression.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE9447
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3151

ID:: 3151

Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...