GEO DataSets

(Submitter supplied) Our hypothesis is that copper modulates the activity of multiple intracellular signal transduction pathways to affect transcription. We have previously shown that copper activates transcription through both metal- and oxidative stress-responsive signal transduction pathways. Since the global molecular mechanisms underlying copper toxicity have not been well elucidated in humans, we have profiled transcriptome changes in HepG2 cells exposed to 100, 200, 400 and 600 uM copper for 4, 8, 12 and 24 hours using a human oligonucleotide microarray. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3640

Platform:

GPL6087

98 Samples

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Analysis of HepG2 liver cells treated with up to 600 uM copper sulfate for up to 24 hours. Copper is an essential trace element but can be extremely toxic at supraphysiological levels. Results provide insight into the molecular basis of copper toxicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, log e ratio, 4 dose, 4 time sets

Platform:

GPL6087

Series:

GSE9539

98 Samples

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(Submitter supplied) This is an alternative version of the official Agilent platform assigned accession number GPL887. The ID column includes the Agilent probe identifiers instead of the Agilent feature IDs. Agilent's Human 1A Oligo Microarray (V2) includes over 20K 60-mer oligonucleotide probes, sourced from the Incyte Foundation Database, RefSeq, and GenBank, and are designed to span conserved exons across the transcripts of the targeted full length genes. more...

Organism:

Homo sapiens

1 DataSet

3 Series

106 Samples

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