GSM2635612[Accession] - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Search results

Items: 4

Select item 2000991971.

Genome Organization Drives Chromosome Fragility

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens; Mus spretus

Type:: Other; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL23505 GPL21697 GPL21626
61 Samples

Download data: BW

Series

Accession:: GSE99197

ID:: 200099197

PubMed Full text in PMC Similar studies

Select item 2000991962.

Genome Organization Drives Chromosome Fragility [nsRNA-seq]

(Submitter supplied) In this study, we show that evolutionarily conserved chromosome loop anchors bound by CTCF and cohesin are vulnerable to DNA double strand breaks (DSBs) mediated by topoisomerase 2B (TOP2B). Polymorphisms in the genome that redistribute CTCF/cohesin occupancy concomitantly rewire DNA cleavage sites to novel contact domain boundaries. While transcription and replication coupled genomic rearrangements have been well documented, we demonstrate that DSBs at loop anchors are transcription-, replication-, and cell type- independent. more...