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Items: 3

1.

cGAS surveillance of micronuclei links genome instability to innate immunity

(Submitter supplied) DNA is strictly compartmentalised within the nucleus to prevent autoimmunity despite this cGAS, a cytosolic sensor of dsDNA, is activated in autoinflammatory disorders and by DNA damage. Precisely how cellular DNA gains access to the cytoplasm remains to be determined. Here, we report that cGAS localises to micronuclei arising from genome instability in a model of monogenic autoinflammation, after exogenous DNA damage and spontaneously in human cancer cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
35 Samples
Download data: CSV
Series
Accession:
GSE100771
ID:
200100771

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2.

NextSeq 550 (Mus musculus)

Organism:
Mus musculus
1283 Series
55348 Samples
Download data
Platform
Accession:
GPL21626
ID:
100021626

3.

MR-scRNAseq-40080044-cell-25

Organism:
Mus musculus
Source name:
single MEF cell, 1 Gy irradiation, no micronuclei
Platform:
GPL21626
Series:
GSE100771
Download data
Sample
Accession:
GSM2693075
ID:
302693075

SRA Run Selector

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db=gds|term=GSM2693075[Accession]|query=5|qty=2|blobid=MCID_666651dcac4a2c10500ad290|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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