GSM386252[Accession] - GEO DataSets

Select item 2000153961.

Peripheral blood mononuclear, DU145, and HCT116 cells treated with a CDK inhibitor

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
156 Samples

Download data: CEL

Series

Accession:: GSE15396

ID:: 200015396

Select item 2000153892.

Peripheral blood mononuclear cells treated with a CDK inhibitor

(Submitter supplied) A genomics-based approach to identify pharmacodynamic biomarkers was used for a CDK (cyclin-dependent kinase) inhibitory drug. R547 is a potent CDK inhibitor with a potent anti-proliferative effect at pharmacologically relevant doses, and is currently in Phase I clinical trials. Utilizing preclinical data derived from microarray experiments, we identified pharmacodynamic biomarkers to test in blood samples from patients in clinical trials. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5266
Platform:: GPL570
37 Samples

Download data: CEL

Series

Accession:: GSE15389

ID:: 200015389

Select item 52663.

Cyclin-dependent kinase inhibitor R547 effect on peripheral blood mononuclear cells: dose response and time course

Analysis of peripheral blood mononuclear cells treated with CDK inhibitor R547 at 2 doses for 2 and 24 hours. R547 exerts an antiproliferative effect on various cell lines. Results compared with those from DU145 (GDS5267) and HCT116 cells (GDS5268) to identify pharmacodynamic biomarkers for R547.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 agent, 3 dose, 3 time sets

Platform:: GPL570
Series:: GSE15389
37 Samples

Download data: CEL

DataSet

Accession:: GDS5266

ID:: 5266

Select item 1000005704.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:: Homo sapiens

602 DataSets
5642 Series
61 Related Platforms
171144 Samples

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Platform

Accession:: GPL570

ID:: 100000570

Select item 3003862525.

PBMCs vehicle treated for 24 hours,replicate 3

Organism:: Homo sapiens

Source name:: PBMCs vehicle treated for 24 hours,replicate 3

Platform:: GPL570
Series:: GSE15389 GSE15396
Dataset:: GDS5266

Download data: CEL

Sample

Accession:: GSM386252

ID:: 300386252

GEO DataSets

Functional Genomics Studies

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