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Items: 6

1.

Transcript atlases reveal that artery tertiary lymphoid organs but not secondary lymphoid organs control key steps of atherosclerosis T cell immunity in aged apoe-/- mice.

(Submitter supplied) Tertiary lymphoid organs (TLOs) emerge in response to nonresolving inflammation but their roles in adaptive immunity remain unknown. Here, we explored artery TLOs (ATLOs) to delineate atherosclerosis T cell responses in apoe-/- mice during aging. Though the T cell repertoire showed systemic age-associated contractions in size and modifications in subtype composition and activation, wt and apoe-/- mice were equally affected. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL8321 GPL1261
65 Samples
Download data: CEL, EXP
Series
Accession:
GSE40156
ID:
200040156
2.

Age-dependent aorta transcriptomes in wild-type and apoE-deficient C57BL/6J mice

(Submitter supplied) We previously observed that formation of aorta and innominate artery atherosclerotic lesions in the intima of hyperlipidemic apoE-deficient mice but not wild-type mice was accompanied by a marked age-dependent adventitial T cell infiltration. As the mice aged, adventitial T cells formed T/T cell-, T/B cell-, and T/B/dendritic cell aggregates adjacent to atherosclerotic lesions. Some of the adventitial infiltrates formed large clusters of various immune cells including T cells, B cells (centrocytes, follicular mantle cells), dendritic cells, follicular dendritic cells, and plasma cells with preferential formation in the suprarenal portion of the abdominal aorta. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL8321 GPL1261
35 Samples
Download data: CEL, EXP
Series
Accession:
GSE10000
ID:
200010000
3.

Aortae of 32 weeks old apoE mice

(Submitter supplied) Aortae of 32 weeks old apoE mice versus wild type mice on a C57BL/6J Background. Keywords = mouse aorta microarray Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1300
Platform:
GPL1261
6 Samples
Download data: CEL, EXP
Series
Accession:
GSE2372
ID:
200002372
4.
Full record GDS1300

Hyperlipidemic model of adaptive immunity in aorta during atherogenesis

Expression profiling of 32 week old aorta in an apolipoprotein E deficient (apoE(-/-)) strain. Results provide insight into a major site of immune cell accumulation during atherosclerosis progression.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 strain sets
Platform:
GPL1261
Series:
GSE2372
6 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1300
ID:
1300
5.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4423 Series
40 Related Platforms
57646 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
6.

wt-Aorta-32-weeks-3

Organism:
Mus musculus
Source name:
total Aorta of 32 weeks old C57BL/6J
Platform:
GPL1261
Series:
GSE2372 GSE10000 GSE40156
Dataset:
GDS1300
Download data: CEL, EXP
Sample
Accession:
GSM44659
ID:
300044659
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