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Items: 6

1.

A function for interleukin 2 in Foxp3-expressing regulatory T cells

(Submitter supplied) Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant immune tolerance to self. Most Treg cells constitutively express the high-affinity interleukin 2 (IL-2) receptor alpha-chain (CD25); however, the precise function of IL-2 in Treg cell biology has remained controversial. To directly assess the effect of IL-2 signaling on Treg cell development and function, we analyzed mice containing the Foxp3gfp knock-in allele that were genetically deficient in either IL-2 (Il2-/-) or CD25 (Il2ra-/-). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2061
Platform:
GPL1261
5 Samples
Download data: CEL
Series
Accession:
GSE4179
ID:
200004179
2.
Full record GDS2061

Interleukin 2 deficient regulatory T cells expressing transcription factor Foxp3

Analysis of interleukin 2 (IL-2)-deficient, Foxp3-expressing regulatory T (Treg) cells. Foxp3+ Treg cells mediate dominant immune tolerance to self. Treg cells express IL-2 receptor alpha-chain CD25, but the role of IL-2 has been controversial to date. Results identify a role for IL-2 in Treg cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 cell type, 4 genotype/variation sets
Platform:
GPL1261
Series:
GSE4179
5 Samples
Download data: CEL
DataSet
Accession:
GDS2061
ID:
2061
3.

Regulatory T cell lineage specification by Foxp3

(Submitter supplied) Examination of CD4+ T cells from Foxp3-GFP knock-in mice. Aim is to understand the genetic program governed by Foxp3 in T cells by comparison of CD4 T cells subdivided into four groups based on expression of Foxp3 and CD25. Keywords = regulatory T cells Keywords = Foxp3 Keywords: repeat sample
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1113
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE2389
ID:
200002389
4.
Full record GDS1113

CD4+ T cells expressing transcription factor Foxp3 and various amounts of CD25

Analysis of CD4+/CD25lo, CD4+/CD25+, and CD4+/CD25hi T cells expressing the forkhead transcription factor Foxp3. FACS used to sort CD4+ cells based on Foxp3 GFP fusion protein and CD25 expression. Results provide insight into the role of Foxp3 in regulatory T cell development and function.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 cell type, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE2389
4 Samples
Download data: CEL
DataSet
Accession:
GDS1113
ID:
1113
5.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4424 Series
40 Related Platforms
57658 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
6.

CD4+ CD25hi Foxp3+ T cells

Organism:
Mus musculus
Source name:
mouse CD4+ T cells
Platform:
GPL1261
Series:
GSE2389 GSE4179
Datasets:
GDS1113 GDS2061
Download data: CEL
Sample
Accession:
GSM44980
ID:
300044980
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