GSM45793[Accession] - GEO DataSets

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Items: 4

Select item 2000024331.

Expression profiling of GATA-1 wild type and mutant fetal megakaryocytes

(Submitter supplied) Background: Children with Down syndrome (DS) are predisposed to acute megakaryoblastic leukemia (AMKL, or AML M7) and a related myeloid disorder, referred to as transient myeloproliferative disorder (TMD), or transient leukemia (TL). Recently, acquired mutations in the erythroid/megakaryocytic lineage-specific transcription factor GATA-1 have been identified in megakaryoblasts from virtually all DS patients with AMKL (DS-AMKL), as well as in nearly all DS neonates with TMD. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1316
Platform:: GPL1261
10 Samples

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Series

Accession:: GSE2433

ID:: 200002433

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Select item 13162.

GATA-1 variant role in Down syndrome megakaryocytic leukemias

Analysis of megakaryocytes and their progenitors from mutant E12.5 embryo liver expressing truncated transcription factor GATA-1. Results provide insight into the role of variant GATA-1 (GATA1s) in megakaryocyte hyperproliferation and Down syndrome (DS)-associated leukemias (TMD, DS-AMKL/DS-AML M7).

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell type, 3 genotype/variation sets

Platform:: GPL1261
Series:: GSE2433
10 Samples

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DataSet

Accession:: GDS1316

ID:: 1316

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Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...