GSM4994803[Accession] - GEO DataSets

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Items: 4

Select item 2001640111.

Regulated sulfur sequestration promotes multicellularity during nutrient limitation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Dictyostelium discoideum

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL26668 GPL29548
46 Samples

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Accession:: GSE164011

ID:: 200164011

PubMed Full text in PMC Similar studies

Select item 2001640092.

Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

(Submitter supplied) Dictyostelium discoideum behavior depends on nutrients1. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism2,3. This unique biology makes D. discoideum an ideal model for investigating how fundamental metabolic pathways command cell differentiation and function. We show here that reactive oxygen species (ROS), generated as a consequence of nutrient limitation, lead to the sequestration of the amino acid cysteine in the antioxidant glutathione, limiting the use of its sulfur atom for processes such as protein translation and FeS cluster-containing enzyme activity that contribute to mitochondrial metabolism and cellular proliferation. more...