GSM5919126[Accession] - GEO DataSets

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Items: 4

Select item 2001975451.

Cell division drives DNA methylation loss in late-replicating domains in primary human cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL23976 GPL24676
448 Samples

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Series

Accession:: GSE197545

ID:: 200197545

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001975122.

Cell division drives DNA methylation loss in late-replicating domains in primary human cells [methylation array]

(Submitter supplied) We present the first experimental evidence that loss of DNA methylation at late-replicating regions, widely documented in aging and cancer, is directly driven by cell division. DNA hypomethylation, particularly at low-density CpGs in A:T-rich, partially methylated domains (PMD solo-WCGWs), tracks cumulative population doublings in primary cell culture. Cell cycle deceleration or full arrest resulted in a proportional decrease in the rate of DNA methylation loss. more...