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Items: 5

1.

Two transactivation mechanisms are responsible for the bulk of HIF-1alpha-responsive gene expression

(Submitter supplied) The C-terminal activation domain (C-TAD) of the hypoxia-inducible transcription factors HIF-1? and HIF-2? binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription. The role of the CH1 domain in vivo is unknown, however. We created mutant mice bearing deletions in the CH1 domains (?CH1) of CBP and p300 that abrogate their interactions with the C-TAD, revealing that the CH1 domains of CBP and p300 are genetically non-redundant and indispensable for C-TAD transactivation function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL1261 GPL339
32 Samples
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Series
Accession:
GSE3318
ID:
200003318
2.

Gene expression in hypoxic MEFs having only p300 and CBP with deleted CH1 domains

(Submitter supplied) The CH1 protein interaction domain of the transcriptional coactivators p300 and CBP is thought to interact with HIF-1alpha and this interaction is thought to be critical to the expression of HIF-1alpha target genes in response to hypoxia. To test the requirement of the CH1 domain for gene expression in response to hypoxia, rimary mouse embryonic fibroblasts (MEFs) were generated from C57Bl/6x129/Sv F2 e14.5 embryos that contain a deletion in the CH1 domain of three of four alleles of CBP and p300. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2161
Platform:
GPL1261
12 Samples
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Series
Accession:
GSE3196
ID:
200003196
3.
Full record GDS2161

CH1 domain deletion, p300 and CBP heterozygous null mutant fibroblasts response to hypoxia

Analysis of hypoxic fibroblasts with deletions in the CH1 domains of p300 and CBP combined with a p300 or CBP allele knockout. CH1 domains interact with the C-TAD domain of hypoxia-inducible transcription factors HIF-1a and -2a. Results provide insight into the role for CH1 domains in hypoxia.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 genotype/variation, 2 stress sets
Platform:
GPL1261
Series:
GSE3196
12 Samples
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4.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4423 Series
40 Related Platforms
57646 Samples
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Platform
Accession:
GPL1261
ID:
100001261
5.

triCH1flox2_1_normoxia

Organism:
Mus musculus
Source name:
primary mouse embryonic fibroblasts
Platform:
GPL1261
Series:
GSE3196 GSE3318
Dataset:
GDS2161
Download data
Sample
Accession:
GSM67327
ID:
300067327
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