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Items: 5

1.

Two transactivation mechanisms are responsible for the bulk of HIF-1alpha-responsive gene expression

(Submitter supplied) The C-terminal activation domain (C-TAD) of the hypoxia-inducible transcription factors HIF-1? and HIF-2? binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription. The role of the CH1 domain in vivo is unknown, however. We created mutant mice bearing deletions in the CH1 domains (?CH1) of CBP and p300 that abrogate their interactions with the C-TAD, revealing that the CH1 domains of CBP and p300 are genetically non-redundant and indispensable for C-TAD transactivation function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL1261 GPL339
32 Samples
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Series
Accession:
GSE3318
ID:
200003318
2.

Gene expression in MEFs in response to treatment with dipyridyl and trichostatin A

(Submitter supplied) The CH1 protein interaction domain of the transcriptional coactivators p300 and CBP is thought to interact with HIF-1alpha and this interaction is thought to be critical to the expression of HIF-1alpha target genes in response to hypoxia. Trichostatin A (TSA), an inhibitor of histone deacetylases, has been reported to repress the expression of HIF-1alpha target genes. To test the requirement of the CH1 domain and TSA for gene expression in response to dipyridyl (a hypoxia mimetic), primary mouse embryonic fibroblasts (MEFs) were generated from C57Bl/6x129/Sv F2 e14.5 embryos that contain a deletion in the CH1 domain of three of four alleles of CBP and p300. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2162
Platform:
GPL1261
16 Samples
Download data
Series
Accession:
GSE3296
ID:
200003296
3.
Full record GDS2162

CH1 domain deletion, p300 and CBP heterozygous null mutant hypoxic fibroblasts response to trichostatin A

Analysis of trichostatin A (TSA)-treated hypoxic fibroblasts with deletions in CH1 domains of p300 and CBP, and a p300 or CBP allele knockout. TSA is a histone deacetylase inhibitor. Results provide insight into the role of deacetylase activity in CH1-independent hypoxia inducible transcription.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 agent, 4 genotype/variation sets
Platform:
GPL1261
Series:
GSE3296
16 Samples
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4.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4423 Series
40 Related Platforms
57646 Samples
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Platform
Accession:
GPL1261
ID:
100001261
5.

triCH1flox1_DP

Organism:
Mus musculus
Source name:
primary mouse embryonic fibroblasts
Platform:
GPL1261
Series:
GSE3296 GSE3318
Dataset:
GDS2162
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Sample
Accession:
GSM67347
ID:
300067347
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