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Items: 4

1.

Analysis of RPE65 loss of function in mouse retina

(Submitter supplied) To characterize gene response in RPE65-/- mouse model of Leber’s congenital amaurosis during progression of the disease, we analyzed differential gene expression in retinae early in the development of the disease, namely before and at the onset of photoreceptor cell death in knock-out mice of 2, 4 and 6 months of age. Keywords: knock out response over time
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1647
Platform:
GPL1261
18 Samples
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Series
Accession:
GSE3249
ID:
200003249
2.
Full record GDS1647

RPE65 null mutant model of Leber's congenital amaurosis

Analysis of retinas of RPE65 null mutants at 2, 4 and 6 months of age. RPE65 is highly expressed in retinal pigment epithelial cells. Mutations in REP65 cause 10-15% of Leber's congenital amaurosis (LCA) cases, a severe form of retinal dystrophy. Results provide insight into early LCA progression.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE3249
18 Samples
Download data
DataSet
Accession:
GDS1647
ID:
1647
3.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4423 Series
40 Related Platforms
57646 Samples
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Platform
Accession:
GPL1261
ID:
100001261
4.

RPE65_KO_2months_retina1

Organism:
Mus musculus
Source name:
Retina of 2 month old RPE65-/- mouse
Platform:
GPL1261
Series:
GSE3249
Dataset:
GDS1647
Download data
Sample
Accession:
GSM70899
ID:
300070899
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