GSM70904[Accession] - GEO DataSets

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Items: 4

Select item 2000032491.

Analysis of RPE65 loss of function in mouse retina

(Submitter supplied) To characterize gene response in RPE65-/- mouse model of Leber’s congenital amaurosis during progression of the disease, we analyzed differential gene expression in retinae early in the development of the disease, namely before and at the onset of photoreceptor cell death in knock-out mice of 2, 4 and 6 months of age. Keywords: knock out response over time

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1647
Platform:: GPL1261
18 Samples

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Series

Accession:: GSE3249

ID:: 200003249

Select item 16472.

RPE65 null mutant model of Leber's congenital amaurosis

Analysis of retinas of RPE65 null mutants at 2, 4 and 6 months of age. RPE65 is highly expressed in retinal pigment epithelial cells. Mutations in REP65 cause 10-15% of Leber's congenital amaurosis (LCA) cases, a severe form of retinal dystrophy. Results provide insight into early LCA progression.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 age, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE3249
18 Samples

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DataSet

Accession:: GDS1647

ID:: 1647

Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...