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Items: 4

1.

Hypoxic regulation of gene expression is dominated by the HIF system and can be mimicked by DMOG

(Submitter supplied) The response of cells to hypoxia is characterised by co-ordinated regulation of many genes. Studies of the regulation of the expression of many of these genes by oxygen has implicated a role for the heterodimeric transcription factor hypoxia inducible factor (HIF). The mechanism of oxygen sensing which controls this heterodimeric factor is via oxygen dependent prolyl and asparaginyl hydroxylation by specific 2-oxoglutarate dependent dioxygenases (PHD1, PHD2, PHD3 and FIH-1). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2758 GDS2759 GDS2760 GDS2761
Platforms:
GPL2507 GPL570 GPL96
39 Samples
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Series
Accession:
GSE3188
ID:
200003188
2.
Full record GDS2760

Hypoxia-inducible factor depletion (HG-U133 2.0)

Analysis of hypoxic MCF-7 breast cancer cells depleted for hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, or both HIF alpha subunits. Results provide insight into the extent of the role of HIF-1alpha and HIF-2alpha in the regulation of gene expression during hypoxia.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL570
Series:
GSE3188
12 Samples
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DataSet
Accession:
GDS2760
ID:
2760
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5500 Series
61 Related Platforms
165146 Samples
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Platform
Accession:
GPL570
ID:
100000570
4.

MCF7_HIF2_2

Organism:
Homo sapiens
Source name:
MCF7, HIF-2alpha siRNA, Hypoxia 1% Oxygen, 16 hours
Platform:
GPL570
Series:
GSE3188
Dataset:
GDS2760
Download data
Sample
Accession:
GSM71544
ID:
300071544
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