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Items: 4

1.

Hypoxic regulation of gene expression is dominated by the HIF system and can be mimicked by DMOG

(Submitter supplied) The response of cells to hypoxia is characterised by co-ordinated regulation of many genes. Studies of the regulation of the expression of many of these genes by oxygen has implicated a role for the heterodimeric transcription factor hypoxia inducible factor (HIF). The mechanism of oxygen sensing which controls this heterodimeric factor is via oxygen dependent prolyl and asparaginyl hydroxylation by specific 2-oxoglutarate dependent dioxygenases (PHD1, PHD2, PHD3 and FIH-1). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2758 GDS2759 GDS2760 GDS2761
Platforms:
GPL2507 GPL96 GPL570
39 Samples
Download data
Series
Accession:
GSE3188
ID:
200003188
2.
Full record GDS2761

Hypoxia-inducible factor depletion (Human-6 BeadChip)

Analysis of hypoxic MCF-7 breast cancer cells depleted for hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, or both HIF alpha subunits. Results provide insight into the extent of the role of HIF-1alpha and HIF-2alpha in the regulation of gene expression during hypoxia.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL2507
Series:
GSE3188
12 Samples
Download data
DataSet
Accession:
GDS2761
ID:
2761
3.

Sentrix Human-6 Expression BeadChip

(Submitter supplied) The Sentrix Human-6 BeadChip can be used to study expression of over 47,000 human transcripts. Researchers can generate whole-genome expression profiles for 6 samples in parallel on a single BeadChip. Array is composed of 3 micron features with average feature redundancy of 30-fold . All features are QCed by sequential hybridizations process called array decoding. Probes are fully screened all-full-length 50-mers. more...
Organism:
Homo sapiens
7 DataSets
55 Series
1420 Samples
Download data: CSV
Platform
Accession:
GPL2507
ID:
100002507
4.

MCF7_HIF1_4_Illumina

Organism:
Homo sapiens
Source name:
MCF7, HIF-1alpha siRNA, Hypoxia 1% Oxygen, 16 hours
Platform:
GPL2507
Series:
GSE3188
Dataset:
GDS2761
Download data
Sample
Accession:
GSM71662
ID:
300071662
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