GEO DataSets

(Submitter supplied) Acetaminophen is the primary cause of acute liver toxicity in Europe/USA. Therefore, the FDA reconsiders recommendations concerning safe acetaminophen dosage/use. Current tests for liver toxicity are no ideal predictive markers for liver injury. Here, ‘omics techniques (global analysis of metabolomic/gene expression responses) may provide additional insight. To better understand acetaminophen-induced responses at low dose, we evaluated effects of (sub-)therapeutic acetaminophen doses on metabolite formation/global gene-expression changes (including, for the first time, miRNA) in blood/urine samples from healthy human volunteers.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10526

60 Samples

Download data: CEL

(Submitter supplied) This is identical to GPL570 but a custom CDF environment was used to extract data [Brainarray Version 12, HGU133Plus2_Hs_ENTREZG]. CDF and other files can be downloaded at: http://brainarray.mbni.med.umich.edu/Brainarray/Database/CustomCDF/12.1.0/entrezg.asp Protocol: see manufacturer's web site

Organism:

Homo sapiens

3 DataSets

7 Series

1 Related Platform

370 Samples

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