GEO DataSets

(Submitter supplied) Interest focuses on genes encoding histone demethylases in hematologic malignancies, such as EZH2 (enhancer of zeste homolog 2). EZH2 mutations were recurrently observed in lymphomas and chronic myeloid malignancies, but data in acute leukemias are limited. We investigated 13 PICALM-MLLT10 (=CALM-AF10) rearranged acute leukemia predominantly of T-lineage (7 m/6 f; 6–53 years) by deep-sequencing for EZH2mut and identified 3 (23%) EZH2mut carriers: one splice site mutation in exon 14, while two patients had missense mutations in the D1 region of exon 5 which interacts with different DNA methyltransferase genes (but no DNMT3Amut was detected in the 13 PICALM-MLLT10-positive patients). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4300

Platform:

GPL570

29 Samples

Download data: CEL

Analysis of mononuclear cells from PICALM-MLLT10-positive T-cell acute lymphoblastic leukemia (T-ALL) patients (2 cases with histone methyltransferase gene EZH2 mutations) and PICALM-MLLT10-negative T-ALL patients. Results provide insight into molecular mechanisms underlying the leukemia subtypes.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 5 disease state, 2 genotype/variation sets

Platform:

GPL570

Series:

GSE30599

29 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:

Homo sapiens

602 DataSets

5645 Series

61 Related Platforms

171173 Samples

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