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Items: 4

1.

Expression data from GW8510 treatment of pancreatic cells

(Submitter supplied) Expression of insulin in terminally differentiated non-beta pancreatic cell types could be important for treating type-1 diabetes. We observed that the kinase inhibitor GW8510 up-regulated insulin expression in mouse pancreatic alpha cells. Gene-expression profiling and gene-set enrichment analysis of GW8510-treated alpha cells suggested coordinate up-regulation of the p53 pathway, which was further implicated in induction of insulin transcript.
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS5502 GDS5503
Platform:
GPL8321
12 Samples
Download data: CEL
Series
Accession:
GSE31102
ID:
200031102
2.
Full record GDS5502

Small molecule GW8510 effect on pancreatic alpha cell

Analysis of pancreatic alpha cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5503, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL8321
Series:
GSE31102
6 Samples
Download data: CEL
3.

[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Mouse Genome 430A 2.0 Array is a single array representing approximately 14,000 well-characterized mouse genes that can be used to explore biology and disease processes. more...
Organism:
Mus musculus
66 DataSets
520 Series
2 Related Platforms
6840 Samples
Download data
Platform
Accession:
GPL8321
ID:
100008321
4.

aTC1_d5_gw8510_3.3uM_bio rep3

Organism:
Mus musculus
Source name:
aTC1 cells, 5-day treatment, 3.3 uM GW8512
Platform:
GPL8321
Series:
GSE31102
Dataset:
GDS5502
Download data: CEL
Sample
Accession:
GSM770007
ID:
300770007
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