GSM786632[Accession] - GEO DataSets

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Items: 3

Select item 2000316921.

A PPARγ-FGF1 axis is required for adaptive adipose remodeling

(Submitter supplied) We identify fibroblast growth factor 1 (FGF1) as a critical transducer in adipose tissue remodeling and link its regulation to peroxisome proliferator activated-receptor γ (PPARγ), the adipocyte master regulator and target of the thiazolidinedione (TZD) class of insulin sensitizing drugs. We show that FGF1 is highly induced in adipose tissue in response to high-fat diet (HFD) and that mice lacking FGF1 develop an aggressive diabetic phenotype coupled to aberrant adipose expansion when challenged with HFD. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
16 Samples

Download data: TXT

Series

Accession:: GSE31692

ID:: 200031692

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000068852.

Illumina MouseRef-8 v2.0 expression beadchip

(Submitter supplied) The MouseRef-8 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...