GSM8035586[Accession] - GEO DataSets

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Items: 4

Select item 2002541821.

Centromeric chromatin in mitosis reorganizes into a functional structure stabilized by cohesin

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Gallus gallus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL32831 GPL19005 GPL26853
100 Samples

Download data: BEDGRAPH, BW

Series

Accession:: GSE254182

ID:: 200254182

Select item 2002541802.

Centromeric chromatin in mitosis reorganizes into a functional structure stabilized by cohesin [Halo-ChIP-seq]

(Submitter supplied) Three-dimensional organization of mitotic chromosomes is established by cohesin and condensin complexes. In the centromere, cohesin maintains sister chromatid pairing until anaphase onset, while condensin provides elastic resistance to spindle forces. However, how condensin and cohesin structure vertebrate centromeres remains unclear. By super-resolution imaging, Capture-C analysis and polymer modeling we show that vertebrate centromeres are partitioned into two condensin-dependent subdomains during mitosis. more...