GEO DataSets

(Submitter supplied) TP53 is mutated in 50% of all cancers, and is often functionally compromised in cancers where it is not mutated. We demonstrate that the pro-tumorigenic/metastatic Six1 homeoprotein decreases p53 levels through a mechanism that does not involve the negative regulator of p53, MDM2. Instead, Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of the ribosomal protein L26 (RPL26), a positive regulator of p53 translation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

5 related Platforms

377 Samples

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(Submitter supplied) The retinoblastoma tumor suppressor, Rb, is implicated in luminal-B and basal-like breast carcinomas, yet its effect on mammary gland development and causal role in breast cancer subtypes remain undefined. Here we show that conditional deletion of Rb in mouse mammary epithelium led to expansion of the stem/progenitor cells and to focal acinar hyperplasia with squamous metaplasia. These uniform lesions progressed into histologically diverse, transplantable mammary adenocarcinomas and adenosquamous carcinomas with features of luminal-B or basal-like carcinomas. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL891 GPL4092 GPL2881

144 Samples

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(Submitter supplied) Mice have been used as models for human breast cancers for many years, however, it is still unclear which murine models faithfully represent human tumor phenotypes. To address this question, we used DNA microarrays to characterize 10 different murine mammary models and compared these data to the expression patterns from primary human breast tumors. Hierarchical clustering analysis of the murine samples showed that the WAP-Myc, MMTV-Neu, MMTV-PyMT, WAP-Int3, and C3(1)-Tag tumors were highly correlated within each model. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

4 related Platforms

354 Samples

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(Submitter supplied) Mouse is the most widely used mammalian model in biological research and target identification. This microarray will enable researchers to simultaneously characterize expression activities of many thousands of mouse genes associated with various biological functions and processes. Content for this empirically validated microarray includes a comprehensive set of toxicology markers determined through collaboration with leaders in toxicogenomics including NIEHS, Toxicogenomics Research Consortium, and Paradigm Genetics Arrays of this design have barcodes that begin with 16011978 or 2511978. more...

Organism:

Mus musculus

10 DataSets

54 Series

1 Related Platform

1505 Samples

Download data: TXT