GSM8133059[Accession] - GEO DataSets

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Items: 4

Select item 2002610471.

Correlation of antigen expression with epigenetic modifications after rAAV delivery of a human Factor IX variant in mice and rhesus macaques

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Macaca mulatta; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

4 related Platforms
64 Samples

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Series

Accession:: GSE261047

ID:: 200261047

Select item 2002610442.

Correlation of antigen expression with epigenetic modifications after rAAV delivery of a human Factor IX variant in mice and rhesus macaques (CnT NHP)

(Submitter supplied) We investigated long-term human coagulation Factor IX expression of a novel variant when delivered into mice and rhesus macaques and compare transduction efficiencies using two different AAV capsids. In hemophilic mice injected with KP1-packaged rAAV expressing the hyperactive FIX variant specific activity plasma levels were 10-fold or 2-fold enhanced when compared to wild-type or Padua huFIX injected mice, respectively. more...