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Items: 4

1.

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity [expression profiling]

(Submitter supplied) The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine and 5-carboxylcytosine. Tet1 is robustly expressed in mouse embryonic stem cells (mESCs) and has been implicated in mESC maintenance. Here we demonstrate that, unlike genetic deletion, RNAi-mediated depletion of Tet1 in mESCs led to a significant reduction in 5hmC and loss of mESC identity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
8 Samples
Download data: CEL
Series
Accession:
GSE34886
ID:
200034886
2.

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Methylation profiling by high throughput sequencing
Platforms:
GPL14661 GPL9250
12 Samples
Download data: BED, CEL, WIG
Series
Accession:
GSE34267
ID:
200034267
3.

[Mouse430_2_Mm_EntrezG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 13]

(Submitter supplied) This is identical to GPL1261 but a custom CDF environment was used to extract data [Brainarray Version 13, Mouse4302_Mm_ENTREZG]. CDF and other files can be downloaded at: (see web link below).
Organism:
Mus musculus
13 Series
1 Related Platform
87 Samples
Download data
Platform
Accession:
GPL14661
ID:
100014661
4.

Tet1-KD ES cells siRNA #1 96hr, rep2

Organism:
Mus musculus
Source name:
E14Tg2a Embryonic Stem Cells
Platform:
GPL14661
Series:
GSE34267 GSE34886
Download data: CEL
Sample
Accession:
GSM846066
ID:
300846066
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