GEO DataSets

(Submitter supplied) Abstract: BACKGROUND: Androgen insensitivity syndrome (AIS) comprises a range of phenotypes from male infertility to complete feminization. Most individuals with AIS carry germline mutations of the androgen receptor (AR) that interfere with or ablate its function. As genital fibroblasts retain expression of the AR in vitro, we used genital skin fibroblasts from normal males and 46,XY females with complete AIS due to known AR mutations to gain insights into the role of the AR in human genital differentiation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

46 Samples

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(Submitter supplied) e tested the responses of normal and AIS genital fibroblasts to dihydrotestosterone (DHT), under culture conditions similar to those that were reported to produce aromatase induction in these cells [8]. Cells were treated with DHT (100-1,000 nM) both at confluency (G0) and during exponential growth, and transcript levels were assessed using DNA microarrays. A compound treatment design type is where the response to administration of a compound or chemical (including biological compounds such as hormones) is assayed. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1836

Platform:

GPL3039

21 Samples

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Analysis of genital fibroblasts from 46,XY females with complete androgen insensitivity syndrome (AIS). Response of cells to dihydrotestosterone examined. Most AIS affected individuals have mutated androgen receptors (AR). Results provide insight into the role of AR in genital differentiation.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 2 agent, 2 disease state, 3 dose, 2 protocol sets

Platform:

GPL3039

Series:

GSE3871

21 Samples

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(Submitter supplied) Material is transferred from microtiter plate wells to the slide surface by an automated print head

Organism:

Homo sapiens

1 DataSet

9 Series

61 Samples

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