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Items: 4

1.

Glucocorticoid-Dependent Hippocampal Transcriptome in Male Rats: Pathway-Specific Alterations with Aging

(Submitter supplied) Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the longstanding hypothesis that chronic GC exposure promotes brain aging/Alzheimer's disease. Here, we adrenalectomized male F344 rats at 15-months-of-age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid-receptor (GR)-activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4757
Platform:
GPL85
39 Samples
Download data: CEL
Series
Accession:
GSE37618
ID:
200037618
2.
Full record GDS4757

Corticosterone effect on hippocampus: dose response

Analysis of hippocampal CA1 from adrenalectomized F344 males maintained for 3 months with implanted corticosterone (CORT) pellets to produce low or intermediate (glucocorticoid receptor-activating) blood levels of CORT. Results provide insight into the effects of chronic CORT on the hippocampus.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 4 agent, 4 dose, 2 protocol sets
Platform:
GPL85
Series:
GSE37618
39 Samples
Download data: CEL
3.

[RG_U34A] Affymetrix Rat Genome U34 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The RG-U34 set includes 3 arrays with a total of 26379 entries and was indexed 29-Jan-2002. more...
Organism:
Rattus norvegicus
98 DataSets
174 Series
1 Related Platform
3495 Samples
Download data
Platform
Accession:
GPL85
ID:
100000085
4.

rat hippocampus (CA1 region), sham, 18 months old, subject 10

Organism:
Rattus norvegicus
Source name:
rat hippocampus (CA1 region)_sham
Platform:
GPL85
Series:
GSE37618
Dataset:
GDS4757
Download data: CEL
Sample
Accession:
GSM923298
ID:
300923298
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