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Items: 6

1.

In vivo function of NR2E3 in establishing photoreceptor identity during mammalian retinal development

(Submitter supplied) Rod and cone photoreceptors in mammalian retina are generated from common pool(s) of neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that control photoreceptor differentiation. Mutations in NR2E3, a rod-specific orphan nuclear receptor, lead to loss of rods, increased density of S-cones, and supernormal S-cone-mediated vision in humans. To better understand its in vivo function, NR2E3 was expressed ectopically in the Nrl-/- retina, where post-mitotic precursors fated to be rods develop into functional S-cones similar to the human NR2E3 disease. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2455
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE5338
ID:
200005338
2.
Full record GDS2455

Photoreceptor-specific nuclear receptor NR2E3 ectopic expression effect on NRL null retinas

Analysis of 4 week-old neural retinal leucine zipper (NRL) null retinas expressing photoreceptor-specific nuclear receptor (NR2E3) from the cone-rod homeobox (CRX) promoter. NRL, NR2E3, and CRX control photoreceptor differentiation. Results provide insight into the molecular function of NR2E3.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 strain sets
Platform:
GPL1261
Series:
GSE5338
8 Samples
Download data: CEL
DataSet
Accession:
GDS2455
ID:
2455
3.

Targeting of GFP to new-born rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors

(Submitter supplied) Purpose: To investigate the gene regulatory networks during photoreceptor differentiation. Special aims: To generate gene expression profiles of purified photoreceptors at distinct developmental stages and from different genetic backgrounds. Background: Rod photoreceptor genesis spans a broad temporal window during retinal development. It starts as early as E12.5 and peaks at P0-P2. At E16.5, there are some early born rods but the peak of rod genesis does not occur. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1693
Platform:
GPL1261
39 Samples
Download data: CEL, TXT
Series
Accession:
GSE4051
ID:
200004051
4.
Full record GDS1693

Transcription factor Nrl deficiency effect on photoreceptor development

Analysis of photoreceptors (PRs) from wild type and Nrl deficient retinas at various developmental stages. PRs isolated based on transgene GFP expression from an Nrl promoter. Nrl ablation leads to cones at the expense of rods. Results provide insight into the regulation of PR development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 5 development stage, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE4051
39 Samples
Download data: CEL
DataSet
Accession:
GDS1693
ID:
1693
5.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4430 Series
40 Related Platforms
57729 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
6.

Nrl-ko-Gfp 4 weeks replicate 4

Organism:
Mus musculus
Source name:
Gfp+ photoreceptor cells
Platform:
GPL1261
Series:
GSE4051 GSE5338
Datasets:
GDS1693 GDS2455
Download data: CEL
Sample
Accession:
GSM92613
ID:
300092613
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