GEO DataSets

(Submitter supplied) Diffuse large B cell lymphomas (DLBCL) constitute a heterogeneous group of lymphomas in which germinal center B cell-like and activated B cell-like subtypes can be discerned based on pathology, clinical presentation and gene expression patterns. Testicular DLBCL form an immune-privileged site-related subgroup of DLBCL with an unfavorable prognosis. We used cDNA microarray analysis, immunohistochemistry for CD10, Bcl6 and MUM1, and somatic hypermutation analysis of the immunoglobulin heavy chain gene rearrangements to determine the subtype of primary testicular DLBCL. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2219

Platform:

GPL3408

36 Samples

Download data: IMAGENE, TXT

Analysis of primary testicular diffuse large B cell lymphomas (DLBCLs) and nodal DLBCLs. DLBCLs are classified as germinal center B cell-like (GCB), activated B cell-like, or undetermined. GCB is associated with a favorable prognosis. Results provide insight into the nature of testicular DLBCL.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 4 disease state, 2 tissue sets

Platform:

GPL3408

Series:

GSE4296

36 Samples

Download data: IMAGENE

(Submitter supplied) Loss of human leukocyte antigen (HLA) expression on tumor cells is frequent in diffuse large B cell lymphoma (DLBCL) arising in immune-privileged sites such as the testis and central nervous system and is associated with small homozygous deletions of HLA-DQ/DR and larger hemizygous deletions of the major histocompatibility complex (MHC) region. To better understand the significance of downregulation of HLA class II expression in relation to the homozygous and hemizygous deletions, we analyzed global gene expression patterns in a series of 26 testicular diffuse large B-cell lymphomas (DLBCL) after characterization of these deletions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1960

Platform:

GPL3408

36 Samples

Download data: IMAGENE, TXT

Analysis of testicular diffuse large B cell lymphoma (DLBCL) tissues with small homozygous HLA-DQ/HLA-DR deletions, larger hemizygous MHC complex deletions, or without deletions. Results provide insight into the significance of the downregulation of HLA class II expression in testicular DLBCL.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 2 disease state, 3 other sets

Platform:

GPL3408

Series:

GSE4157

36 Samples

Download data: IMAGENE

(Submitter supplied) Spotted cDNA microarray containing 19200 spots: 768 control/empty spots and 18432 cDNA clones, selected from the Research Genetics Human Sequence Verified library. Clones were selected based on the availability of annotation data. Protocol: See CMF website: http://microarray.nki.nl/download/protocols_o.html

Organism:

Homo sapiens

2 DataSets

3 Series

114 Samples

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