GEO DataSets

(Submitter supplied) The role of placental macrophages is largely ignored in the success of pregnancy. We found that CD14+ macrophages purified from at-term placentas spontaneously matured into multinucleated giant cells (MGCs). MGCs lost the expression of CD14 and co-inhibitory molecules, such as Programmed cell Death-Ligands 1 and 2. Although MGCs kept phagocytosis and property to produce ROS, their inflammatory potential measured by TNF/IL-10 imbalance and activation of p38 MAPK and NF-κB was blunted without being associated with M2 phenotype. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5314

Platform:

GPL6480

12 Samples

Download data: TXT

Analysis of placental multinucleated giant cells (MGCs) obtained from at-term placental CD14+ macrophages cultured in DMEM-F12 containing 10% FCS and antibiotics for 9 days. Results provide insight into molecular mechanisms underlying the maturation of macrophages into MGCs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type sets

Platform:

GPL6480

Series:

GSE38747

12 Samples

Download data: TXT

(Submitter supplied) This multi-pack (4X44K) formatted microarray represents a compiled view of the human genome as it is understood today. The sequence information used to design this product was derived from a broad survey of well known sources such as RefSeq, Goldenpath, Ensembl, Unigene and others. The resulting view of the human genome covers 41K unique genes and transcripts which have been verified and optimized by alignment to the human genome assembly and by Agilent's Empirical Validation process. more...

Organism:

Homo sapiens

21 DataSets

942 Series

4 Related Platforms

24826 Samples

Download data