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GeneReviews

Pagon RA, Adam MP, Ardinger HH, et al., editors

University of Washington (Seattle WA); 1993-2014.

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Items: 1 to 20 of 6433

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1.

miR181a is a novel key player in the STAT3 mediated survival network of TCRab CD8+ T-LGL leukemia [sRNA-Seq]

(Submitter supplied) TCRαβ CD8 large granular lymphocyte (LGL) leukemia is a rare heterogeneous hematological disorder with a chronic disease course that mostly affects elderly. It is generally accepted that LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of dysregulation of mainly the STAT3 but also to some extent the ERK pathway, which are constitutively activated. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL16791
13 Samples
Download data: CSV
Series
Accession:
GSE159878
ID:
200159878
2.

miR181a is a novel key player in the STAT3 mediated survival network of TCRab CD8+ T-LGL leukemia [RNA-Seq]

(Submitter supplied) TCRαβ CD8 large granular lymphocyte (LGL) leukemia is a rare heterogeneous hematological disorder with a chronic disease course that mostly affects elderly. It is generally accepted that LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of dysregulation of mainly the STAT3 but also to some extent the ERK pathway, which are constitutively activated. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
16 Samples
Download data: CSV, TXT
Series
Accession:
GSE159819
ID:
200159819
3.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

(Submitter supplied) Hexokinases (HK) catalyze the first step of glycolysis and thereby limit its pace. HK2 is highly expressed in the gut epithelium, plays a role in immune responses and is upregulated in inflammation and ulcerative colitis 1-3. Here, we examined the microbial regulation of HK2 and its impact on intestinal inflammation by generating mice lacking HK2 specifically in intestinal epithelial cells (Hk2∆IEC). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
38 Samples
Download data: TXT
Series
Accession:
GSE158026
ID:
200158026
4.

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development

(Submitter supplied) Eukaryotic genomes harbor invading transposable elements silenced by PIWI-interacting RNAs (piRNAs) to maintain genome integrity in animal germ cells. However, whether piRNAs also regulate endogenous gene expression programs remains unclear. Here, we show that C. elegans piRNAs trigger the transcriptional silencing of hundreds of spermatogenic genes during spermatogenesis, promoting sperm differentiation and function. more...
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL19757
40 Samples
Download data: BW
Series
Accession:
GSE157319
ID:
200157319
5.

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [small RNA-IP-seq]

(Submitter supplied) Eukaryotic genomes harbor invading transposable elements silenced by PIWI-interacting RNAs (piRNAs) to maintain genome integrity in animal germ cells. However, whether piRNAs also regulate endogenous gene expression programs remains unclear. Here, we show that C. elegans piRNAs trigger the transcriptional silencing of hundreds of spermatogenic genes during spermatogenesis, promoting sperm differentiation and function. more...
Organism:
Caenorhabditis elegans
Type:
Other
Platform:
GPL19757
24 Samples
Download data: BW
Series
Accession:
GSE157318
ID:
200157318
6.

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [RNA-seq]

(Submitter supplied) Eukaryotic genomes harbor invading transposable elements silenced by PIWI-interacting RNAs (piRNAs) to maintain genome integrity in animal germ cells. However, whether piRNAs also regulate endogenous gene expression programs remains unclear. Here, we show that C. elegans piRNAs trigger the transcriptional silencing of hundreds of spermatogenic genes during spermatogenesis, promoting sperm differentiation and function. more...
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19757
7 Samples
Download data: BW
Series
Accession:
GSE157317
ID:
200157317
7.

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development [GRO-seq]

(Submitter supplied) Eukaryotic genomes harbor invading transposable elements silenced by PIWI-interacting RNAs (piRNAs) to maintain genome integrity in animal germ cells. However, whether piRNAs also regulate endogenous gene expression programs remains unclear. Here, we show that C. elegans piRNAs trigger the transcriptional silencing of hundreds of spermatogenic genes during spermatogenesis, promoting sperm differentiation and function. more...
Organism:
Caenorhabditis elegans
Type:
Other
Platform:
GPL19757
9 Samples
Download data: BW
Series
Accession:
GSE157316
ID:
200157316
8.

Maternal diet disrupts the placenta-brain axis in a sex-specific manner

(Submitter supplied) Purpose: Next generation bulk RNA sequencing of a large group (37 individuals) of matched tissues (fetal brain and fetal placenta) from human fetuses collected via elective termination at 72-82 days post conception (d.p.c.), a timeframe that closely matches the embryonic developmental window used in our mouse studies (14.5-16.5) Methods: Human placenta (maternal decidua separated from fetal placenta) and fetal brain tissues were obtained from the NIH-supported Laboratory of Developmental Biology at the University of Washington between the years 1999 and 2010 and used under a protocol approved by the Duke University Institutional Review Board (Pro00014066). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
70 Samples
Download data: CSV
Series
Accession:
GSE188872
ID:
200188872
9.

Single Cell RNA Profiles of a Human Triple Negative Breast Cancer

(Submitter supplied) To investigate the transcriptional dynamics of the breast tumor microenvironment, remnant surgical tissue from an AJCC stage III triple negative invasive ductal carcinoma resected at Wake Forest Baptist Medical Center (WFBMC) in Winston Salem, NC, was accessed via Wake Forest University Health Sciences Institutional Review Board protocol IRB00048977 and expression profiled by single cell RNA sequencing. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
1 Sample
Download data: MTX, TSV
Series
Accession:
GSE188600
ID:
200188600
10.

Bulk RNA of IL-4 and squalene treated MDM

(Submitter supplied) We performed bulk RNA-seq on squalene/M-CSF-treated macrophages to compute the fold change of genes in the squalene/M-CSF compared to M-CSF alone treated macrophages. We then looked at the distribution of the log fold changes in the skin-derived TREM2 (607 genes) and M2-like (709 genes) macrophage scRNA-seq signatures. We found that the TREM2 gene signature was more highly induced by squalene/M-CSF than the M2-like macrophage signature. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: TXT
Series
Accession:
GSE188363
ID:
200188363
11.

Transcriptomic Analysis of Wound Healing and Skin Rejuvenation Following Ablative Fractional Laser Treatment of Human Skin

(Submitter supplied) Ablative fractional laser treatment is considered the gold standard for skin rejuvenation. In order to understand how fractional laser works to rejuvenate skin, we performed microarray profiling on skin biopsies to identify temporal and dose-response changes in gene expression following fractional laser treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
140 Samples
Download data: CEL
Series
Accession:
GSE168760
ID:
200168760
12.

Cancer coopts differentiation of B-cell precursors into macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL21810 GPL20844
27 Samples
Download data: TXT
Series
Accession:
GSE180285
ID:
200180285
13.

Cancer coopts differentiation of B-cell precursors into macrophages [human]

(Submitter supplied) We recently reported that some cancers induce accumulation of bone marrow (BM) B-cell precursors in the spleen to convert them into metastasis-promoting, immunosuppressive B cells. Here, using various murine tumor models and samples from humans with breast and ovarian cancers, we provide evidence that cancer cells also coopt differentiation of the extranodal B-cell precursors to generate macrophages (termed B-MF). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20844
15 Samples
Download data: TXT
Series
Accession:
GSE180284
ID:
200180284
14.

Comprehensive RNA-seq transcriptomic profiling in adult T lymphoblastic leukemia

(Submitter supplied) RNA-seq data to study expression profiles in different adult T lymphoblastic leukemia
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13393
41 Samples
Download data
Series
Accession:
GSE142520
ID:
200142520
15.

Cancer -associated mutations in XPO1 transform cells through altered nuclear export signal recognition

(Submitter supplied) Proper nucleocytoplasmic distribution of proteins is essential to cellular homeostasis but what role the altered nuclear export machinery commonly described in cancer cells plays in cancer initiation is not known. Here, genomic analysis of 42,793 cancers identified recurrent mutational hotspots in XPO1, the main nuclear export receptor in eukaryotic cells. Expression of XPO1 mutations in vivo was sufficient to initiate clonal, B-lymphoproliferative disorders by altering the constellation of proteins exported from the nucleus based on amino acid charge C-terminal to their nuclear export signal. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL13112
43 Samples
Download data: TXT
Series
Accession:
GSE120231
ID:
200120231
16.

Transcriptomic profiling for research of molecular mechanisms implicated in the differentation of Human Neural Stem Cells

(Submitter supplied) We conduct RNA sequencingof the human neural stem hNS1 as a in vitro model to profile gene expression alterations in differentiation versus proliferation and we analyzed the relevance of the deregulated genes and a review of signaling pathways and analogies with previous information obtained from neural databases
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
6 Samples
Download data: TXT
Series
Accession:
GSE182285
ID:
200182285
17.

Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast [SNP array]

(Submitter supplied) During pregnancy, normal extravillous trophoblast (EVT) invade the endomyometrium of the maternal uterus and remodel the spiral arteries to control blood supply and nutrient transfer. Recent reports have described first trimester EVT as polyploid and senescent. Here we extend these earlier reports by performing comprehensive profiling of the genomic organization and transcriptome of first trimester EVT and term EVT. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL23668
12 Samples
Download data: IDAT, TXT
Series
Accession:
GSE173369
ID:
200173369
18.

Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast [RNA-seq]

(Submitter supplied) During pregnancy, normal extravillous trophoblast (EVT) invade the endomyometrium of the maternal uterus and remodel the spiral arteries to control blood supply and nutrient transfer. Recent reports have described first trimester EVT as polyploid and senescent. Here we extend these earlier reports by performing comprehensive profiling of the genomic organization and transcriptome of first trimester EVT and term EVT. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
36 Samples
Download data: XLSX
Series
Accession:
GSE173323
ID:
200173323
19.

Gene expression profile of human mesenchymal stromal cells (MSCs) exposed to hypoxic and pseudohypoxic preconditioning

(Submitter supplied) We performed gene expression profiling by RNA sequencing (RNA-Seq) to fully characterize the gene regulation effect induced by exposure of MSCs to two hypoxic preconditioning methods. We determined the gene expression profile of 6 populations of human MSCs isolated from bone marrow and preconditioned for 6h in 2% O2 (hypoxia) or with 40μM Vadadustat (pseudohypoxia), compared to control cells cultured in 21% O2. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18460
18 Samples
Download data: SF, TXT
Series
Accession:
GSE180371
ID:
200180371
20.

Modeling Hepatoblastoma: Identification of Distinct Tumor Cell Populations and Key Genetic Mechanisms through Single Cell Sequencing (scRNA-seq)

(Submitter supplied) Hepatoblastoma (HB) is the most common primary liver malignancy of childhood. However, molecular investigations of the disease are limited and effective treatment options are lacking. The use of patient derived xenografts (PDX) to study biology and treatment strategies of HB has proven to be a useful tool. There is currently a knowledge gap in the investigation of key driver cells of HB in PDX models. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
7 Samples
Download data: H5AD, TAR, XLSX
Series
Accession:
GSE180665
ID:
200180665
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