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Biochemistry, 5th edition

Berg JM, Tymoczko JL, Stryer L.

W H Freeman (New York); 2002.

Search results

Items: 20

1.

Transcriptomic characterization of a mixed population of pluripotent stem cell derived cerebellar neuron-like progenitors

(Submitter supplied) We set out to ascertain whether it was possible to use PSCs (pluripotent stem cells) to generate a mix of neuronal cell types resembling those in the cerebellum, most notably Purkinje and granule cells. Several groups have previously demonstrated generation of cerebellar-like neuronal cells from murine ESCs (embryonic stem cells), and more recently the Erceg group achieved similar success using human PSCs. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE65423
ID:
200065423
2.

Global transcriptomic changes of either cell cycle arrested parasites or cell cycle re-entered asexual P. falciparum 3D7 parasites.

(Submitter supplied) Parasitic protists, including Plasmodium falciparum malaria parasites, evolved sophisticated biological features to adapt and survive in e.g. mosquito vectors and mammalian hosts. The parasite’s life cycle is extraordinarily controlled, oscillating between quiescent stages (e.g. sporozoites or gametocytes) and stages of intense proliferation. The atypical mode of asexual reproduction in erythrocytes (schizogony: asynchronous nuclear division in the absence of cytokinesis), is clearly divergent from cell division in higher eukaryotes but the mechanisms that control cell cycle progression are poorly understood. more...
Organism:
Plasmodium falciparum
Type:
Expression profiling by array
Platform:
GPL17233
32 Samples
Download data: GPR
Series
Accession:
GSE92289
ID:
200092289
3.

Molecular signatures of neural connectivity in the olfactory cortex

(Submitter supplied) Purpose:This work aimed to identify the genetic profiles of piriform projection neurons and characterize their spatial organization within the piriform cortex. Methods: We microdissected the three layers of pirifrom cortex by laser capture (LMD) and performed RNA deep sequencing in order to identify layer-specific molecular markers, we then validated these data by using RNA in situ hybridization and immunohistochemistry.We next performed anterograde neural tracing experiments to identify piriform target regions, and retrograde neural tracing experiments to analyze how piriform projection neurons are organized within piriform cortex.We then combined the analysis of patterns of gene expression with retrograde tracing experiments to identify molecular signatures of the different subclasses of piriform projecting neurons. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
9 Samples
Download data: TSV
Series
Accession:
GSE70800
ID:
200070800
4.

Wide-scale transcriptome disturbance underlies liver and kidney pathology from chronic ultra low dose Roundup exposure [kidney]

(Submitter supplied) Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH residues pose a particular risk to the kidneys and liver. However, the existence of biological effects with negative health implications at low environmentally relevant doses remains unresolved. A previous investigation addressed this issue, by conducting a 2-year feeding study, which included 10 female Sprague Dawley rats administered via drinking water with 0.1 ppb of a major Roundup formulation (50 ng/L glyphosate equivalent dilution). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL17117
19 Samples
Download data: CEL
Series
Accession:
GSE66059
ID:
200066059
5.

Wide-scale transcriptome disturbance underlies liver and kidney pathology from chronic ultra low dose Roundup exposure [liver]

(Submitter supplied) Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH residues pose a particular risk to the kidneys and liver. However, the existence of biological effects with negative health implications at low environmentally relevant doses remains unresolved. A previous investigation addressed this issue, by conducting a 2-year feeding study, which included 10 female Sprague Dawley rats administered via drinking water with 0.1 ppb of a major Roundup formulation (50 ng/L glyphosate equivalent dilution). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL17117
20 Samples
Download data: CEL
Series
Accession:
GSE66058
ID:
200066058
6.

UV-B dose and time range finding study on mouse biopsy skin samples

(Submitter supplied) In molecular biology, the design of mechanistic experiments has to be optimized by considering statistical and biological principles. In contrast to statistical principles, biological principles of experimental design are not universally formulated. In an attempt to pinpoint generally acceptable rules, we investigated the importance of determining the optimal ranges of scale of i.e. dose and time in gene expression experiments. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17736
57 Samples
Download data: FTR
Series
Accession:
GSE51348
ID:
200051348
7.

UV-C dose and time range finding study on Mouse Embryonic Fibroblasts (MEFs)

(Submitter supplied) In molecular biology, the design of mechanistic experiments has to be optimized by considering statistical and biological principles. In contrast to statistical principles, biological principles of experimental design are not universally formulated. In an attempt to pinpoint generally acceptable rules, we investigated the importance of determining the optimal ranges of scale of i.e. dose and time in gene expression experiments. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17736
48 Samples
Download data: FTR
Series
Accession:
GSE50930
ID:
200050930
8.

Expression data from Foxl2 wild-type and mutant ovaries and testes

(Submitter supplied) Foxl2 is a forkhead transcription factor expressed only in the female, but not in the male gonad. We have created mice homozygous mutant for the Foxl2 gene (KO) as well as mice carrying a conditional mutant Foxl2 allele (floxed). The expression profiles of conventional Foxl2 knockout and wildtype ovaries were compared at P3, using the Affy Mouse Genome 430 2.0 Array. Adult wildtype and conditional mutant (Foxl2 floxed x RosaCre-EBD treated with tamoxifen) ovaries were compared to adult wildtype testes using the Affymetrix Mouse Gene 1.0 ST Array. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL1261 GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE16853
ID:
200016853
9.

Ovary at P3, Foxl2 KO, replicate 2

Organism:
Mus musculus
Source name:
Mouse ovary, P3, Foxl2 KO
Platform:
GPL1261
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422402
ID:
300422402
10.

Ovary at P3, Foxl2 KO, replicate 1

Organism:
Mus musculus
Source name:
Mouse ovary, P3, Foxl2 KO
Platform:
GPL1261
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422401
ID:
300422401
11.

Ovary at P3, wild-type, replicate 2

Organism:
Mus musculus
Source name:
Mouse ovary, P3, wildtype
Platform:
GPL1261
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422400
ID:
300422400
12.

Ovary at P3, wild-type, replicate 1

Organism:
Mus musculus
Source name:
Mouse ovary, P3, wildtype
Platform:
GPL1261
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422399
ID:
300422399
13.

Adult ovary, Foxl2 mutant, replicate 3

Organism:
Mus musculus
Source name:
Mouse ovary, adult,Foxl2 flox/flox x CreEBD
Platform:
GPL6246
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422398
ID:
300422398
14.

Adult ovary, Foxl2 mutant, replicate 2

Organism:
Mus musculus
Source name:
Mouse ovary, adult,Foxl2 flox/flox x CreEBD
Platform:
GPL6246
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422397
ID:
300422397
15.

Adult ovary, Foxl2 mutant, replicate 1

Organism:
Mus musculus
Source name:
Mouse ovary, adult,Foxl2 flox/flox x CreEBD
Platform:
GPL6246
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422396
ID:
300422396
16.

Adult ovary, wild-type, replicate 2

Organism:
Mus musculus
Source name:
Mouse ovary, adult, wildtype
Platform:
GPL6246
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422395
ID:
300422395
17.

Adult ovary, wild-type, replicate 1

Organism:
Mus musculus
Source name:
Mouse ovary, adult, wildtype
Platform:
GPL6246
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422394
ID:
300422394
18.

Adult testis, wild-type, replicate 3

Organism:
Mus musculus
Source name:
Mouse testis, adult, wildtype
Platform:
GPL6246
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422393
ID:
300422393
19.

Adult testis, wild-type, replicate 2

Organism:
Mus musculus
Source name:
Mouse testis, adult, wildtype
Platform:
GPL6246
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422392
ID:
300422392
20.

Adult testis, wild-type, replicate 1

Organism:
Mus musculus
Source name:
Mouse testis, adult, wildtype
Platform:
GPL6246
Series:
GSE16853
Download data: CEL
Sample
Accession:
GSM422391
ID:
300422391
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