GEO DataSets

(Submitter supplied) The Barcelona Robertsonian system (BRbS) presents mice with standard karyotype (diploid number 40) but also carrying Robertsonian fusions (ehich lead to variable diploid numbers ranging from 28 to 39). To study the heterogeneity of their genetic background and possible genome divergence between them, samples from three populations were genotyped.

Organism:

Mus musculus domesticus; Mus musculus

Type:

Genome variation profiling by array

Platform:

GPL34100

24 Samples

Download data: IDAT, TXT

(Submitter supplied) The laboratory mouse (Mus musculus domesticus) has long been used in biomedical research due to its easy maintenance and availability of abundant genetic information. However, laboratory mice have an inherent disadvantage of low genetic diversity caused by their origin from a relatively small colony of “fancy mice” in western Europe. Recently captured wild mice (wild-derived mice) are expected to compensate for this shortcoming because of their greater genetic diversity. more...

Organism:

Mus musculus castaneus; Mus musculus domesticus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL29744 GPL33115

13 Samples

Download data: XLSX

(Submitter supplied) The RNA exosome complex (EC) confers post-transcriptional regulation by processing and degrading RNAs in a context-dependent manner. Although the EC functions in diverse cell types, its contributions to stem and progenitor cell development have not been widely studied. Previously, we demonstrated that the transcriptional regulator of erythrocyte development GATA1 represses genes encoding EC subunits, and in vitro analyses implicated the EC in maintaining erythroid progenitors. more...

Organism:

Mus musculus domesticus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL29744

6 Samples

Download data: TXT

(Submitter supplied) We tested whether Dis3 and Exosc10 depletion impact erythropoiesis by interfering with RNA processing and generating an aberrant transcriptome.

Organism:

Mus musculus domesticus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL29744

12 Samples

Download data: TXT

(Submitter supplied) Structural data of genome organization in somatic cells (fibroblasts) and germ cells (primary spermatocytes and round spermatids) from wild mice with Rb fusions from the Barcelona Rb System.

Organism:

Mus musculus domesticus

Type:

Other

Platform:

GPL17637

3 Samples

Download data: H5

(Submitter supplied) Hybrid phenotypes that contribute to postzygotic reproductive isolation often exhibit pronounced asymmetry, both between reciprocal crosses and between the sexes in accordance with Haldane's rule. Inviability in mammalian hybrids is associated with parent-of-origin placental growth abnormalities for which misregulation of imprinted genes is the leading candidate mechanism. However, direct evidence for the involvement of imprinted genes in hybrid growth dysplasia is limited. more...

Organism:

Mus musculus domesticus; Mus spretus; Mus musculus domesticus x Mus spretus

Type:

Methylation profiling by high throughput sequencing

Platforms:

GPL26185 GPL26184 GPL26187

29 Samples

Download data: TXT

(Submitter supplied) Background: Island populations repeatedly evolve extreme body sizes, but the genomic basis of this morphological pattern remains largely unknown. To understand how organisms on islands evolve gigantism, we compared genome-wide patterns of gene expression in Gough Island mice, the largest wild house mice in the world, and mice from the WSB/EiJ wild-derived inbred strain. In a highly replicated experiment, we used RNASeq to quantify differences in gene expression in three key metabolic organs: gonadal adipose depot, hypothalamus, and liver. more...

Organism:

Mus musculus domesticus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26986

100 Samples

Download data: TXT, VCF

(Submitter supplied) Eosinophils are terminally differentiated granulocytes that recently have been shown to become infected with Influenza A Virus (IAV). Here, we investigate transcriptional changes that occur to bone marrow-derived eosinophils following exposure to IAV. Global changes in the transcriptome of bone marrow derived mouse eosiniphils were assessed following mock- and Influenza A virus-infection using Affymetrix mouse gene 2.0 ST microarrays.

Organism:

Mus musculus; Mus musculus domesticus

Type:

Expression profiling by array

Platform:

GPL16570

20 Samples

Download data: CEL, CHP

(Submitter supplied) The findings in our study revealed dynamic differences of gene expression and different pathways of immune response in mice infected with three distinct strains of T. gondii.

Organism:

Mus musculus domesticus; Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

45 Samples

Download data: CEL, CHP, XLSX

(Submitter supplied) The mammalian placenta is both the physical interface between mother and fetus, and the source of endocrine signals that target the maternal hypothalamus, priming females for parturition, lactation and motherhood. Despite the importance of this connection, the effects of altered placental signaling on the maternal brain are understudied. Here, we show that placental dysfunction alters gene expression in the maternal brain, with the potential to affect maternal behavior. more...

Organism:

Mus musculus domesticus x Mus spretus; Mus spretus; Mus musculus domesticus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL26184 GPL26187 GPL26185

44 Samples

Download data: CSV, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Mus musculus domesticus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL23907 GPL22601

12 Samples

Download data: RCC

(Submitter supplied) We used the NanoString mouse nCounter immunology panel platform to compare mRNA gene expression profiles of spelnocytes from placebo-, E2, and EE exposed NZB/WF1 mice. With the profling of 548 immunology-related genes, we found that E2 and EE exposure alter immune-related genes at a similar pattern.

Organism:

Mus musculus; Mus musculus domesticus

Type:

Expression profiling by array

Platform:

GPL23907

6 Samples

Download data: RCC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus domesticus

Type:

Expression profiling by array

Platforms:

GPL23907 GPL23908

96 Samples

Download data

(Submitter supplied) The clinical success of chimeric antigen receptor (CAR) T-cell therapy for CD19+ B-cell malignancies may come at the expense of acute and chronic morbidities. Some patients suffer from significant, acute toxicities and those with persistent CAR T-cells require immunoglobulin therapy due to CAR-induced B-cell aplasia. Life-threatening effects include cytokine release syndrome, the exact etiology of which is unclear. more...

Organism:

Mus musculus domesticus

Type:

Expression profiling by array

Platform:

GPL23908

48 Samples

Download data: TXT

(Submitter supplied) The clinical success of chimeric antigen receptor (CAR) T-cell therapy for CD19+ B-cell malignancies may come at the expense of acute and chronic morbidities. Some patients suffer from significant, acute toxicities and those with persistent CAR T-cells require immunoglobulin therapy due to CAR-induced B-cell aplasia. Life-threatening effects include cytokine release syndrome, the exact etiology of which is unclear. more...

Organism:

Mus musculus domesticus

Type:

Expression profiling by array

Platform:

GPL23907

48 Samples

Download data: TXT

(Submitter supplied) The placental epigenome plays a vital role in regulating mammalian growth and development. Aberrations in placental DNA methylation are linked to several disease states, including intrauterine growth restriction and preeclampsia. Studying the evolution and development of the placental epigenome is critical to understanding the origin and progression of such diseases. Although high resolution studies have found substantial variation between placental methylomes of different species, the nature of methylome variation has yet to be characterized within any individual species. more...

Organism:

Mus spretus; Mus musculus musculus; Mus musculus domesticus

Type:

Methylation profiling by high throughput sequencing

Platforms:

GPL22153 GPL17637 GPL17106

35 Samples

Download data: BW

(Submitter supplied) Though exercise is critical for health and wellbeing, many lack the motivation to exercise, and it is unclear how motivation might be increased. To uncover the molecular underpinnings of increased motivation for exercise, we analyzed the transcriptome of the striatum in four mouse lines selectively bred for high voluntary wheel running and four non-selected control lines. The striatum was dissected and RNA was extracted and sequenced from four individuals of each strain. more...

Organism:

Mus musculus domesticus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17637

31 Samples

Download data: TXT

(Submitter supplied) Here we examine the expression of genes in unstimulated or following intraperitoneal injection with MegaFasL in MSM/Ms and C57BL/6 mouse livers and thymi

Organism:

Mus musculus molossinus; Mus musculus domesticus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL20867 GPL20866

8 Samples

Download data: TXT

(Submitter supplied) We report on a genome-wide scan for introgression in the house mouse (Mus musculus domesticus) involving the Algerian mouse (Mus spretus), using 20 samples from the ranges of sympatry and allopatry. Our analysis reveals significant variability in introgression signatures along the genomes, as well as across the samples. We find that fewer than half of the chromosomes in each genome harbor all detectable introgression. more...

Organism:

Mus musculus domesticus; Mus musculus

Type:

SNP genotyping by SNP array

Platform:

GPL13147

6 Samples

Download data: CEL

(Submitter supplied) Analysis of DNA methylation in the bed nucleus of the stria terminalis/preoptic area and striatum in response to perinatal testosterone exposure. The hypothesis tested was that treatment of females with testosterone on the day of birth would lead to masculinization of the methylome in adulthood.

Organism:

Mus musculus domesticus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL17637

24 Samples

Download data: TXT