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Items: 1 to 20 of 921

1.

Epigenetic aging of the demographically non-aging naked mole-rat [RRBS]

(Submitter supplied) The naked mole-rat (NMR) is an exceptionally long-lived rodent that does not show increased mortality with age, uniquely defining NMR as a demographically non-aging mammal. Here, we performed bisulfite sequencing on over one hundred NMR blood samples differing in age, assessing more than 3 million common CpG sites. We observed an information loss of the NMR methylome during aging suggesting that NMR ages. more...
Organism:
Heterocephalus glaber
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL21195
107 Samples
Download data: COV
Series
Accession:
GSE179039
ID:
200179039
2.

Methylation studies in mole rats. Part 2

(Submitter supplied) An Infinium microarray platform (GPL28271, HorvathMammalMethylChip40) was used to generate DNA methylation data from many tissues of 3 species of mole rats: Cape mole rat (Georychus capensis), Damaraland mole rat (Cryptomys damarensis), Naked mole rat (Heterocephalus glaber). We generated DNA methylation data from n=94 tissues from 3 species: Cryptomys damarensis (n=10), Georychus capensis (n=6), Heterocephalus glaber (n=78). more...
Organism:
Georychus capensis; Rattus norvegicus; Heterocephalus glaber; Mus musculus; Fukomys damarensis; Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL28271
94 Samples
Download data: IDAT
Series
Accession:
GSE174778
ID:
200174778
3.

Methylation studies in naked mole rat. Part 1

(Submitter supplied) An Infinium microarray platform (GPL28271, HorvathMammalMethylChip40) was used to generate DNA methylation data from many tissues of the naked mole rat We generated DNA methylation data from n=289 tissues. All tissues except for skin biopsies and blood were obtained from frozen tissue collection that were euthanized for other studies. Skin biopsies (2 mm punch) were collected from the backs of the animals under local anesthesia. more...
Organism:
Mus musculus; Heterocephalus glaber; Rattus norvegicus; Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL28271
289 Samples
Download data: IDAT
Series
Accession:
GSE174777
ID:
200174777
4.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data
Series
Accession:
GSE185724
ID:
200185724
5.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [sorted_BM_PB_THY]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Download data: RDATA
Series
Accession:
GSE185723
ID:
200185723
6.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [Xeno]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Download data: RDATA
Series
Accession:
GSE185722
ID:
200185722
7.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [LY]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the T cell developmental landscape in Naked mole-rats and showed
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: RDATA
Series
Accession:
GSE185721
ID:
200185721
8.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [BM]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.
Organism:
Mus musculus; Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: RDATA
Series
Accession:
GSE185720
ID:
200185720
9.

Naked mole rat cells are protected from cellular senescence via Wnt/β-catenin-promoted cholesterol metabolism

(Submitter supplied) The naked mole rat (NMR; Heterocephalus glaber) exhibits cancer resistance and an exceptionally long lifespan of approximately 30 years. The longevity of the NMR is widely debated, as it poses challenges to theories associated with aging, cancer, and redox homeostasis. In the present study, we report unique mechanisms of cholesterol metabolism in NMR cells that could be responsible in part for their anti-senescent properties. more...
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21195
2 Samples
Download data: CSV
Series
Accession:
GSE147871
ID:
200147871
10.

DNA methylation clocks as a predictor for ageing and age estimation in naked mole-rats, Heterocephalus glaber

(Submitter supplied) The naked mole-rat, Heterocephalus glaber (NMR), the longest-lived rodent with a maximum possible lifespan exceeding 33 years, is emerging as an important non-model organism for the study of longevity and healthspan. As such it is of significance and interest in the study of biomarkers for ageing in mammals. Recent breakthroughs in this field have indicated that ‘epigenetic clocks’ based on the temporal accumulation of DNA methylation at specific genomic sites can enable accurate age estimates for tissues across the lifespan of an individual. more...
Organism:
Heterocephalus glaber
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL27526
39 Samples
Download data: CSV
Series
Accession:
GSE137957
ID:
200137957
11.

Droplet-based single-cell RNA-sequencing of mouse and naked mole-rat spleen and circulating immune cells, in natural conditions, following lipopolysaccharide (LPS) challanege, and saline control

(Submitter supplied) Single-cell RNA-sequencing was performed in the mouse and naked mole-rat immune systems in order to map and compare their immune cell repertoirs and their cell-specific gene-expression responses to LPS challenge
Organism:
Mus musculus; Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21103 GPL26775
63 Samples
Download data: CSV
Series
Accession:
GSE132642
ID:
200132642
12.

Comparative transcriptome analysis reveals naked mole rat liver adaptations to hypoxia

(Submitter supplied) This study compares the transcriptional response to hypoxia in liver of the hypoxia-tolerant naked mole rat (NMR) and the hypoxia-sensitive rat.
Organism:
Rattus norvegicus; Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13793 GPL14844
6 Samples
Download data: TXT
Series
Accession:
GSE71612
ID:
200071612
13.

RNA-seq of breeding and non-breeding naked mole-rats and guinea pigs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Heterocephalus glaber; Cavia porcellus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21195 GPL22346
476 Samples
Download data
Series
Accession:
GSE98719
ID:
200098719
14.

RNA-seq of naked mole-rat liver from breeders and non-breeders [livers]

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of naked mole-rat liver from breeders and non-breeders.
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21195
23 Samples
Download data: XLS
Series
Accession:
GSE98667
ID:
200098667
15.

RNA-seq of nine naked mole-rat tissues from breeders and non-breeders

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of nine different naked mole-rat tissue from breeders and non-breeders.
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21195
215 Samples
Download data: XLS
Series
Accession:
GSE98663
ID:
200098663
16.

RNA-seq of naked mole-rat liver from young and old animals

(Submitter supplied) Comparison of gene expression level by Illumina sequencing of naked mole-rat liver from young and old animals. We identified differentially expressed genes and provide functional profiles, which give insights into the aging process of long-lived rodents.
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21195
9 Samples
Download data: XLS
Series
Accession:
GSE98744
ID:
200098744
17.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: naked mole-rat]

(Submitter supplied) We used liver samples from Naked Mole Rat to determine rate of change of methylation with respect to age.
Organism:
Heterocephalus glaber
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL24046
24 Samples
Download data: TXT
Series
Accession:
GSE104215
ID:
200104215
18.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Canis lupus familiaris; Macaca mulatta; Mus musculus; Heterocephalus glaber
Type:
Methylation profiling by high throughput sequencing; Methylation profiling by genome tiling array
Platforms:
GPL24046 GPL13534 GPL22370
84 Samples
Download data: TXT
Series
Accession:
GSE86059
ID:
200086059
19.

Aging in naked mole-rats and rats

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus; Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18694 GPL21195
18 Samples
Download data
Series
Accession:
GSE98746
ID:
200098746
20.

Naked mole rat cells show resistance to iPSC reprogramming and signs of more stable epigenome

(Submitter supplied) Naked mole rat (NMR) is a valuable model for aging and cancer research due to its exceptional longevity and resistance to tumorigenesis. In an effort to generate NMR induced pluripotent stem cells (iPSCs) we observed that reprogramming efficiency of NMR fibroblasts in repsonse to OSKM overexpression was drasticaly lower than that of mouse fibroblasts. To understand the cause of NMR resistance to reprogramming we screened for factors that improve reprogramming effciency. more...
Organism:
Mus musculus; Heterocephalus glaber
Type:
Other
Platforms:
GPL21195 GPL17021
4 Samples
Download data: BED, BEDGRAPH
Series
Accession:
GSE83585
ID:
200083585
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