GEO DataSets

(Submitter supplied) The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 subjects were recruited for screening of differentially expressed plasma microRNAs. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and was positively correlated with age. Cell senescence induced the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induced vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. more...

Organism:

Homo sapiens; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Merkel cell polyomavirus; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus hominis; Human alphaherpesvirus 2; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL21439

12 Samples

Download data: GPR, XLSX

(Submitter supplied) Excessive alcohol consumption adversely affects the immune system and triggers the activation of peripheral blood (PB) monocytes and tissue macrophages, contributing to alcohol- related organ damage. This study aimed to analyze the M1/M2 and inflammatory phenotypes of circulating monocytes and macrophage-derived monocytes (MDMs). This single-center cross- sectional study included 20 excessive alcohol drinkers (EADs) and 22 healthy controls. more...

Organism:

Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Rattus norvegicus; Human alphaherpesvirus 2; Merkel cell polyomavirus; Mus musculus cytomegalovirus 2

Type:

Non-coding RNA profiling by array

Platform:

GPL11434

22 Samples

Download data: GPR, TXT

(Submitter supplied) Silencing of the adaptor SH3BP2 impairs Gastrointestinal stromal tumors growth through miRNAs We dissected SH3BP2 pathway in Gastrointestinal Stromal Tumor cells (GIST) performing a miRNA array in SH3BP2-silenced GIST cells

Organism:

Human alphaherpesvirus 2; Betapolyomavirus hominis; Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL21599

12 Samples

Download data: TXT, XLSX

(Submitter supplied) Characterization of pluripotent states, in which cells can both self-renew or differentiate, with the irreversible loss of pluripotency, are important research areas in developmental biology. Although microRNAs (miRNAs) have been shown to be crucial for embryonic stem (ES) self-renewal maintenance and cellular differentiation, the role of miRNAs integrated into gene regulatory networks and its dynamic changes during these state transitions remain elusive. more...

Organism:

human gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus macacae; Human alphaherpesvirus 2; Murid gammaherpesvirus 4; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Betapolyomavirus hominis; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL18658

12 Samples

Download data: TXT

(Submitter supplied) MicroRNAs profile of circulating CD4+ T Cells in Aged Patients with Atherosclerosis Obliterans comparing healthy persons without symptoms or lesion associated with atherosclerosis.

Organism:

JC polyomavirus; Human alphaherpesvirus 2; Lymphocryptovirus; Homo sapiens; Rhadinovirus; Human immunodeficiency virus 1; Merkel cell polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL26002

14 Samples

Download data: GPR, XLSX

(Submitter supplied) Using the highly sensitive miRNA microarray, we screened 107 up-regulated microRNAs and 33 down-regulated microRNAs in the INT-HA-induced M2-like macrophages and we explored the functions of these miRNAs in macrophage polarization. The enrichment results indicated that these miRNAs might participate in the process of macrophage polarization. Furthermore, the quantitative real-time polymerase chain reaction results showed that miR-935 may play an important role in M2 macrophage polarization which was activated by INT-HA.

Organism:

Human immunodeficiency virus 1; Human betaherpesvirus 6B; Herpesvirus saimiri (strain 11); JC polyomavirus; Betapolyomavirus macacae; Human alphaherpesvirus 2; Merkel cell polyomavirus; Homo sapiens; Betapolyomavirus hominis

Type:

Non-coding RNA profiling by array

Platform:

GPL24594

6 Samples

Download data: GPR

(Submitter supplied) An improved mechanistic understanding of the thyroid hormone (TH) action on bile acid (BA) synthetic pathway, the major route for cholesterol elimination, will facilitate the identification of novel therapeutic targets for hypercholesterolemia. Here, we show that hepatic miR-378 is positively regulated by TH. Transient overexpression of miR-378 in the liver of mice reduces the serum cholesterol levels, which is accompanied with an upregulation of key enzymes involved in the intrahepatic conversion of cholesterol to BAs. more...

Organism:

human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL20794

1 Sample

Download data: TXT, XLS

(Submitter supplied) The potential mechanism were successfully illustrated through detecting different expression of microRNAs in between proinflammatory high density lipprotein (pHDL), nomal high density lipprotein (nHDL) and control group, to study whether microRNAs play important roles in the endothelial dysfunction caused by pHDL.

Organism:

Human immunodeficiency virus 1; JC polyomavirus; Homo sapiens; Rhadinovirus; Human alphaherpesvirus 2; Lymphocryptovirus; Merkel cell polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL29064

3 Samples

Download data: XLS

(Submitter supplied) To explore the miRNAs associated with the memory deficits in Alzheimer's disease, we detected the miRNA profiles in the hippocampus of 6-month-old male APPswe/PS1dE9 (APP/PS1) mice and age-matched wild type C57BL/6 mice.

Organism:

Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Betapolyomavirus hominis; human gammaherpesvirus 4; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Human alphaherpesvirus 2; Human betaherpesvirus 6B; Merkel cell polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL21439

6 Samples

Download data: GPR

(Submitter supplied) The expression profile of miRNAs in soft palate muscle of patients with OSAHS (obstructive sleep apnea/hypopnea syndrome) and chronic tonsillitis was examined using miRNA microarray analysis. Combining with the following real time PCR and bioinformatics analysis, the physiological importance of the miRNA-autophagy interconnection is far more likely to be elucidated.

Organism:

Homo sapiens; Rhadinovirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human alphaherpesvirus 2; JC polyomavirus; Betapolyomavirus hominis; Human alphaherpesvirus 1; Cytomegalovirus; Lymphocryptovirus; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL19128

8 Samples

Download data: GPR, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Human alphaherpesvirus 2; JC polyomavirus; Betapolyomavirus hominis; Homo sapiens; Rhadinovirus; Merkel cell polyomavirus; Human alphaherpesvirus 1; Cytomegalovirus; Lymphocryptovirus; Betapolyomavirus macacae; Human immunodeficiency virus 1

Type:

Expression profiling by array; Expression profiling by high throughput sequencing; Non-coding RNA profiling by array; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL18573 GPL19128 GPL571

75 Samples

Download data: CEL, TXT

(Submitter supplied) CDK4/6 inhibition is now part of the standard armamentarium for patients with estrogen receptor (ER)-positive breast cancer, so that defining mechanisms of resistance is a pressing issue. Here, we identify increased CDK6 expression as a key determinant of acquired resistance after exposure to palbociclib in ER-positive breast cancer cells. Increased CDK6 in resistant cells was dependent on TGF-β pathway suppression via miR-432-5p expression. more...

Organism:

Human alphaherpesvirus 2; Lymphocryptovirus; Cytomegalovirus; Betapolyomavirus macacae; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Homo sapiens; Human alphaherpesvirus 1; Rhadinovirus; Betapolyomavirus hominis

Type:

Non-coding RNA profiling by array

Platform:

GPL19128

9 Samples

Download data: TXT

(Submitter supplied) Lipopolysaccharide stimulated primary human monocyte-derived macrophages at 2, 4 and 8hrs, IL-10 at 4hrs, IL-10+LPS at 4hrs

Organism:

human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Rattus norvegicus; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Murid gammaherpesvirus 4; Betapolyomavirus hominis

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

6 Samples

Download data: TXT

(Submitter supplied) HUVECs were transduced with lentiviral vIRF1 or control lentivirus (pHAGE),microarray-based miRNA expression profiling was adopted and identified a set of miRNAs that were differentially expressed between vIRF1- and pHAGE-transduced HUVECs

Organism:

Human alphaherpesvirus 2; Betapolyomavirus hominis; Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8

Type:

Non-coding RNA profiling by array

Platforms:

GPL21439 GPL20712

6 Samples

Download data: TXT

(Submitter supplied) microRNAs profiling of human serum comparing control fertile women with women who had experienced repeated implantation failure after ovarian stimulation and IVF-ET. Repeated implantation failure was defined as women who had undergone≥3 failed cycles with high-grade embryos were transferred.

Organism:

Homo sapiens; Rhadinovirus; Merkel cell polyomavirus; Human alphaherpesvirus 2; Lymphocryptovirus; Betapolyomavirus hominis; Human alphaherpesvirus 1; Cytomegalovirus; Betapolyomavirus macacae; JC polyomavirus; Human immunodeficiency virus 1

Type:

Non-coding RNA profiling by array

Platform:

GPL19128

6 Samples

Download data: GPR, TXT

(Submitter supplied) We first examined changes of miRNAs and expression using microarrays ( Exiqon miRCURY™ microarray LNA v.18.0) of GCs from 10 bPOI and 10 age and BMI matched normal control women. Seventy-five miRNAs (Fold Change [FC]>2, P<0.05) were identified differentially expressed between bPOI patients and control women.

Organism:

Cytomegalovirus; Betapolyomavirus macacae; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Lymphocryptovirus; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Homo sapiens; Rhadinovirus; Betapolyomavirus hominis

Type:

Non-coding RNA profiling by array

Platform:

GPL19128

20 Samples

Download data: GPR, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

20 Samples

Download data

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).

Organism:

Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus hominis; human gammaherpesvirus 4; Betapolyomavirus macacae; Murid gammaherpesvirus 4

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

9 Samples

Download data: XLS

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).

Organism:

Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Mus musculus; Human gammaherpesvirus 8; Human alphaherpesvirus 1; human gammaherpesvirus 4; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL7722

11 Samples

Download data: XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Merkel cell polyomavirus; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human alphaherpesvirus 2; human gammaherpesvirus 4; Mus musculus cytomegalovirus 2; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL11434

12 Samples

Download data: GPR