GEO DataSets

(Submitter supplied) Influenza A virus (FLUAV) poses a significant threat to both humans and animals. While vaccination serves as the primary defense against influenza, the effectiveness of currently approved vaccines is suboptimal. To address this issue, we have developed modified live virus (MLV) vaccines against influenza using genome rearrangement techniques targeting the internal gene segments of FLUAV. The rearranged M2 (RAM) strategy involves cloning the M2 ORF downstream of the PB1 ORF in segment 2 and incorporating multiple early stop codons within the M2 ORF in segment 7. more...

Organism:

Influenza A virus; Mus musculus

Type:

Protein profiling by protein array

Platform:

GPL30424

112 Samples

Download data: TXT

(Submitter supplied) Influenza B virus (FLUBV) is a major respiratory pathogen of humans. Seasonal influenza vaccines include either one or both FLUBV lineage strains, Victoria, and Yamagata. Vaccine mismatch occurs frequently, particularly in countries where vaccines contain only one of the lineages. We have previously described the safety and efficacy of modified live attenuated FLUBV vaccines based on either virus with rearranged genomes (FluB-RAM and FluB-RANS) or carrying a PB1 segment with a combination of temperature sensitive mutations and a C-terminal HA tag (FluB-att). more...

Organism:

Mus musculus; Influenza B virus; Influenza A virus

Type:

Protein profiling by protein array

Platform:

GPL32304

106 Samples

Download data: TXT

(Submitter supplied) Deep sequencing of cDNA from Streptococcus pneumoniae EF3030 bacteria and normalized human broncial epithelial cells (nHBEC), alone, together, and after coincubation with Influenza A virus pH1N1.

Organism:

Influenza A virus; Streptococcus pneumoniae; Homo sapiens

Type:

Expression profiling by high throughput sequencing

5 related Platforms

14 Samples

Download data: MATRIX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Influenza A virus; Influenza B virus

Type:

Protein profiling by protein array

Platforms:

GPL32236 GPL32237

3420 Samples

Download data

(Submitter supplied) Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays (NCT01317758 and NCT01317745). more...

Organism:

Homo sapiens; Influenza A virus; Influenza B virus

Type:

Protein profiling by protein array

Platform:

GPL32237

450 Samples

Download data: CSV, TXT

(Submitter supplied) Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays (NCT01317758 and NCT01317745). more...

Organism:

Homo sapiens; Influenza B virus; Influenza A virus

Type:

Protein profiling by protein array

Platform:

GPL32237

450 Samples

Download data: CSV, TXT

(Submitter supplied) Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays (NCT01317758 and NCT01317745). more...

Organism:

Homo sapiens; Influenza B virus; Influenza A virus

Type:

Protein profiling by protein array

Platform:

GPL32237

480 Samples

Download data: CSV, TXT

(Submitter supplied) Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays (NCT01317758 and NCT01317745). more...

Organism:

Homo sapiens; Influenza B virus; Influenza A virus

Type:

Protein profiling by protein array

Platform:

GPL32237

480 Samples

Download data: CSV, TXT

(Submitter supplied) Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays (NCT01317758 and NCT01317745). more...

Organism:

Homo sapiens; Influenza A virus; Influenza B virus

Type:

Protein profiling by protein array

Platform:

GPL32237

390 Samples

Download data: CSV, TXT

(Submitter supplied) Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays (NCT01317758 and NCT01317745). more...

Organism:

Homo sapiens; Influenza A virus; Influenza B virus

Type:

Protein profiling by protein array

Platform:

GPL32237

390 Samples

Download data: CSV, TXT

(Submitter supplied) Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays (NCT01317758 and NCT01317745). more...

Organism:

Influenza A virus; Influenza B virus; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL32236

390 Samples

Download data: CSV, TXT

(Submitter supplied) Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays (NCT01317758 and NCT01317745). more...

Organism:

Influenza A virus; Homo sapiens; Influenza B virus

Type:

Protein profiling by protein array

Platform:

GPL32236

390 Samples

Download data: CSV, TXT

(Submitter supplied) Individualized antibody reacitivty levels for SARS-CoV-2 antigens were successfully quantified and reactivity classification (Reactive non reactive) was performed based on a logistic regression model. Individuals were tested at several time points including their reactivity before the mRNA vaccination (Pfizer and Moderna), soon after first and second doses and up to 6 months after immunization

Organism:

Influenza A virus; Severe acute respiratory syndrome-related coronavirus; Homo sapiens; Middle East respiratory syndrome-related coronavirus; Severe acute respiratory syndrome coronavirus 2

Type:

Protein profiling by protein array

Platform:

GPL32091

1373 Samples

Download data: CSV, XLS

(Submitter supplied) Influenza B virus (IBV) is considered a major respiratory pathogen responsible for seasonal respiratory disease in humans, particularly severe in children and the elderly. Seasonal influenza vaccination is considered the most efficient strategy to prevent and control IBV infections. Live attenuated influenza virus vaccines (LAIVs) are thought to induce both humoral and cellular immune responses by mimicking a natural infection, but their effectiveness have recently come into question. more...

Organism:

Influenza A virus; Mus musculus

Type:

Protein profiling by protein array

Platform:

GPL30424

144 Samples

Download data: XLSX

(Submitter supplied) Live attenuated influenza virus (LAIV) vaccines elicit a combination of systemic and mucosal immunity by mimicking a natural infection. To further enhance protective mucosal responses, we incorporated the gene encoding the IgA-inducing protein (IGIP) into the LAIV genomes of the cold-adapted A/Leningrad/134/17/57 (H2N2) strain (caLen) and the experimental attenuated backbone A/turkey/Ohio/313053/04 (H3N2) (OH/04att). more...

Organism:

Mus musculus; Influenza B virus; Influenza A virus

Type:

Protein profiling by protein array

Platform:

GPL30336

112 Samples

Download data: XLS

(Submitter supplied) Combining variant antigens into a multivalent vaccine is a traditional approach used to provide broad coverage against antigenically variable pathogens, such as polio, human papilloma and influenza viruses. However, strategies for increasing the breadth of antibody coverage beyond the vaccine are not well understood, but may provide more anticipatory protection. Influenza virus hemagglutinin (HA) is a prototypic variant antigen. more...

Organism:

Influenza B virus; Influenza A virus; Mus musculus

Type:

Protein profiling by protein array

Platform:

GPL30316

112 Samples

Download data: TXT

(Submitter supplied) Effective methods for predicting COVID-19 disease trajectories are urgently needed. Here, enzyme-linked immunosorbent assay (ELISA) and coronavirus antigen microarray (COVAM) analysis mapped antibody epitopes in the plasma of COVID-19 patients (n = 86) experiencing a wide range of disease states. The experiments identified antibodies to a 21-residue epitope from nucleocapsid (termed Ep9) associated with severe disease, including admission to the intensive care unit (ICU), requirement for ventilators, or death. more...

Organism:

Human parainfluenza virus 4b; Influenza B virus; Human respirovirus 1; human metapneumovirus; Human respiratory syncytial virus B; Human adenovirus sp.; Human coronavirus 229E; Human respirovirus 3; Influenza A virus; Human coronavirus NL63; Severe acute respiratory syndrome-related coronavirus; Homo sapiens; Human respiratory syncytial virus A; Dromedary camel coronavirus; Human orthorubulavirus 2; Human coronavirus OC43; Human coronavirus HKU1; Severe acute respiratory syndrome coronavirus 2

Type:

Protein profiling by protein array

Platform:

GPL30021

90 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Influenza A virus; Homo sapiens

Type:

Other; Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL29160

11 Samples

Download data

(Submitter supplied) RIG-I is thought to be the most important sensor of influenza virus infection and plays critical roles in the recognition of cytoplasmic dsRNA and activation of type I IFNs and initiates the innate antiviral immune responses. How the binding of viral RNA to and activation of RIG-I are regulated remains enigmatic. Here, by an affinity proteomics approach with viral RNA as the bait, we found that IFI16, previously identified as a DNA sensor, was significantly induced both in vitro and in vivo during influenza virus infection. more...

Organism:

Influenza A virus; Homo sapiens

Type:

Other

Platforms:

GPL29160 GPL16791

3 Samples

Download data

(Submitter supplied) The Influenza A virus (IAV) is a continuous health threat to humans as well as animals due to its high mutational rate and recurring epidemics and pandemics. The IAV genome is segmented and the eight negative-sense viral RNAs (vRNAs) are transcribed into positive sense RNAs (cRNAs) and viral messenger RNAs (vmRNAs) inside infected host cells. A role for the secondary structure of vmRNAs has been hypothesized and debated for many years, but knowledge on the structure vmRNAs adopt in vivo is currently missing. more...

Organism:

Escherichia coli; Influenza A virus

Type:

Other

Platforms:

GPL21222 GPL25780 GPL24947

20 Samples

Download data: FASTA, WIG