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Items: 1 to 20 of 452

1.

MicroRNA-mediated suppression of the TGF-β pathway confers transmissible and reversible CDK4/6 inhibitor resistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Human immunodeficiency virus 1; Human polyomavirus 1; Human alphaherpesvirus 1; Cytomegalovirus; Lymphocryptovirus; Macaca mulatta polyomavirus 1; Homo sapiens; Rhadinovirus; Merkel cell polyomavirus; Human alphaherpesvirus 2; JC polyomavirus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Non-coding RNA profiling by array; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL18573 GPL19128 GPL571
75 Samples
Download data: CEL, TXT
Series
Accession:
GSE117748
ID:
200117748
2.

MicroRNA-mediated suppression of the TGF-ß pathway confers transmissible and reversible CDK4/6 inhibitor resistance (miRNA array)

(Submitter supplied) CDK4/6 inhibition is now part of the standard armamentarium for patients with estrogen receptor (ER)-positive breast cancer, so that defining mechanisms of resistance is a pressing issue. Here, we identify increased CDK6 expression as a key determinant of acquired resistance after exposure to palbociclib in ER-positive breast cancer cells. Increased CDK6 in resistant cells was dependent on TGF-β pathway suppression via miR-432-5p expression. more...
Organism:
Homo sapiens; Human alphaherpesvirus 1; Rhadinovirus; Macaca mulatta polyomavirus 1; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Cytomegalovirus; Human polyomavirus 1; Human alphaherpesvirus 2; Lymphocryptovirus
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
9 Samples
Download data: TXT
Series
Accession:
GSE117745
ID:
200117745
3.

A focused deep mutational scan on the Env transmembrane and proximal cytosolic regions reveals an absence of sequence features for MA association

(Submitter supplied) The HIV-1 surface glycoprotein Env binds target receptors to mediate fusion of the viral and host cell membranes during infection. Env is incorporated with very low density into virions, and in some cell types, regions within the long cytosolic C-terminal tail may mediate direct or indirect associations with Gag during virus assembly and budding. Here, the mutational landscape is determined across the transmembrane and proximal cytosolic domains of Env (001428 isolate from clade C) interacting with the MA domain of Gag at cellular membranes. more...
Organism:
Human immunodeficiency virus 1
Type:
Other
Platform:
GPL23868
5 Samples
Download data: XLSX
Series
Accession:
GSE126136
ID:
200126136
4.

Mutational tolerance of HIV-1 Env in the CD4, VRC01 and PG16 bound states

(Submitter supplied) HIV-1 infection begins with binding of the viral envelope glycoprotein Env to the host receptor CD4, triggering a series of conformational changes that lead to fusion of the virus and cell membranes. Env, a trimer of gp120 and gp41 subunits, occupies a ‘closed’ conformation with contacts between gp120 subunits at the apex, and transitions through an ‘open’ conformation with the gp120 subunits spread apart following CD4 binding. more...
Organism:
Human immunodeficiency virus 1
Type:
Other
Platforms:
GPL22068 GPL23868
21 Samples
Download data: XLSX
Series
Accession:
GSE102276
ID:
200102276
5.

Deep mutational scanning of Env from the HIV-1 strain DU422 for binding to CD4 and PG16

(Submitter supplied) The HIV-1 genome gains access to the inside of a cell via the mechanism of the viral spike protein Env, which undergoes a series of major conformational rearrangements after binding target receptors that ultimately drive virus-cell membrane fusion. Env is expressed as a heterogenous ensemble of conformations, which can inappropriately misdirect the host immune response towards the production of non-protective, strain-specific antibodies. more...
Organism:
Human immunodeficiency virus 1
Type:
Other
Platform:
GPL22068
22 Samples
Download data: XLSX
Series
Accession:
GSE117328
ID:
200117328
6.

microRNA responses of LPS and IL-10 stimulated primary human monocyte-derived macrophages over a short time-course

(Submitter supplied) Lipopolysaccharide stimulated primary human monocyte-derived macrophages at 2, 4 and 8hrs, IL-10 at 4hrs, IL-10+LPS at 4hrs
Organism:
Rattus norvegicus; Murid gammaherpesvirus 4; Human polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
6 Samples
Download data: TXT
Series
Accession:
GSE125572
ID:
200125572
7.

Microarray-based miRNA expression,identified miRNAs that were regulated by KSHV vIRF1

(Submitter supplied) HUVECs were transduced with lentiviral vIRF1 or control lentivirus (pHAGE),microarray-based miRNA expression profiling was adopted and identified a set of miRNAs that were differentially expressed between vIRF1- and pHAGE-transduced HUVECs
Organism:
Human gammaherpesvirus 4; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human betaherpesvirus 6B; Macaca mulatta polyomavirus 1; Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Human polyomavirus 1; Human alphaherpesvirus 2
Type:
Non-coding RNA profiling by array
Platforms:
GPL20712 GPL21439
6 Samples
Download data: TXT
Series
Accession:
GSE119034
ID:
200119034
8.

human serum: Control vs. patients with repeated implantation failure

(Submitter supplied) microRNAs profiling of human serum comparing control fertile women with women who had experienced repeated implantation failure after ovarian stimulation and IVF-ET. Repeated implantation failure was defined as women who had undergone≥3 failed cycles with high-grade embryos were transferred.
Organism:
Human alphaherpesvirus 1; Cytomegalovirus; Macaca mulatta polyomavirus 1; JC polyomavirus; Human immunodeficiency virus 1; Human alphaherpesvirus 2; Lymphocryptovirus; Homo sapiens; Rhadinovirus; Merkel cell polyomavirus; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
6 Samples
Download data: GPR, TXT
Series
Accession:
GSE106307
ID:
200106307
9.

Differentially expressed miRNA in biological premature ovarian insufficiency (bPOI)

(Submitter supplied) We first examined changes of miRNAs and expression using microarrays ( Exiqon miRCURY™ microarray LNA v.18.0) of GCs from 10 bPOI and 10 age and BMI matched normal control women. Seventy-five miRNAs (Fold Change [FC]>2, P<0.05) were identified differentially expressed between bPOI patients and control women.
Organism:
JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Homo sapiens; Rhadinovirus; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Lymphocryptovirus; Cytomegalovirus; Human polyomavirus 1; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
20 Samples
Download data: GPR, TXT
Series
Accession:
GSE100238
ID:
200100238
10.

Mechanical stretch induced transcriptomic profiles in cardiac myocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Murid gammaherpesvirus 4; Human polyomavirus 1; Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
20 Samples
Download data
Series
Accession:
GSE107380
ID:
200107380
11.

Mechanical stretch induced transcriptomic profiles in cardiac myocytes [24-48 hours]

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).
Organism:
Human gammaherpesvirus 4; Murid gammaherpesvirus 4; Human polyomavirus 1; Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
9 Samples
Download data: XLS
Series
Accession:
GSE107379
ID:
200107379
12.

Mechanical stretch induced transcriptomic profiles in cardiac myocytes [1-12 hours]

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).
Organism:
Mus musculus; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Human alphaherpesvirus 1; Macaca mulatta polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
11 Samples
Download data: XLS
Series
Accession:
GSE107378
ID:
200107378
13.

Differentially expressed miRNAs in granulosa cell of diminished ovarian reserve (DOR) patients

(Submitter supplied) To investigate the pathogenesis of diminished ovarian reserve, differentially expressed miRNAs in granulosa cells were constructed through miRCURYTM LNA expression Array.
Organism:
Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Rattus norvegicus; Human alphaherpesvirus 2; Murid gammaherpesvirus 4; Merkel cell polyomavirus; Mus musculus cytomegalovirus 2; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL11434
6 Samples
Download data: GPR
Series
Accession:
GSE111771
ID:
200111771
14.

MiR-106a increases granulosa cell viability and is down-regulated in women with diminished ovarian reserve

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Mus musculus cytomegalovirus 2; Macaca mulatta polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Merkel cell polyomavirus
Type:
Non-coding RNA profiling by array
Platform:
GPL11434
12 Samples
Download data: GPR
Series
Accession:
GSE111774
ID:
200111774
15.

Differentially expressed miRNAs in serum of diminished ovarian reserve (DOR) patients

(Submitter supplied) To investigate the pathogenesis of diminished ovarian reserve, differentially expressed miRNAs in serum were constructed through miRCURYTM LNA expression Array.
Organism:
Human alphaherpesvirus 1; Human betaherpesvirus 5; Mus musculus cytomegalovirus 2; Macaca mulatta polyomavirus 1; Mus musculus; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Rattus norvegicus; Human alphaherpesvirus 2; JC polyomavirus; Murid gammaherpesvirus 4; Homo sapiens; Murid betaherpesvirus 1; Merkel cell polyomavirus; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL11434
6 Samples
Download data: GPR
Series
Accession:
GSE111773
ID:
200111773
16.

In cell Mutational Interference Mapping Experiment (in cell MIME) identifies the 5’ PolyA signal as a dual regulator of HIV-1 genomic RNA production and packaging

(Submitter supplied) Non-coding RNA regulatory elements are important for viral replication, making them promising targets for therapeutic intervention. However, regulatory RNA is challenging to detect and characterise using classical structure-function assays. Here, we present in cell Mutational Interference Mapping Experiment (in cell MIME) as a way to define RNA regulatory landscapes at single nucleotide resolution under native conditions. more...
Organism:
Human immunodeficiency virus 1
Type:
Other
Platform:
GPL20319
27 Samples
Download data: TXT
17.

Snail-dependent epithelial splicing regulatory protein 1 (ESRP1) silencing drives malignant transformation of human pulmonary epithelial cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Homo sapiens; Human polyomavirus 1; Rattus norvegicus; Murid gammaherpesvirus 4
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL570 GPL7723
8 Samples
Download data: CEL
Series
Accession:
GSE108137
ID:
200108137
18.

Snail-dependent epithelial splicing regulatory protein 1 (ESRP1) silencing drives malignant transformation of human pulmonary epithelial cells [miRNA]

(Submitter supplied) The significance of epithelial-to-mesenchymal transition (EMT)-inducing transcription factors in the onset of non-small cell lung cancer has not been resolved. Here, we report increased Snail expression in pulmonary premalignant lesions relative to histologically normal-appearing pulmonary epithelium. Utilizing immortalized human pulmonary epithelial cells and isogenic derivatives, we document Snail-dependent anchorage-independent growth of the epithelial cells in vitro, as well as transformation, primary tumor growth, and metastatic behavior in vivo. more...
Organism:
Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human polyomavirus 1; Murid gammaherpesvirus 4
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
4 Samples
Download data: TXT
Series
Accession:
GSE108136
ID:
200108136
19.

Profiling of microRNA expression in canine mammary cancer

(Submitter supplied) MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. On account of this, we performed large-scale profiling of microRNA expression in canine mammary cancer.
Organism:
Human alphaherpesvirus 2; Human betaherpesvirus 6B; Human polyomavirus 1; Homo sapiens; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Merkel cell polyomavirus; Canis lupus familiaris; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL21439
171 Samples
Download data: TXT
Series
Accession:
GSE103093
ID:
200103093
20.

Control of microRNA expression by mitochondrial function

(Submitter supplied) Normal cellular function requires communication between mitochondria and the nucleus, termed mitochondria-to-nucleus retrograde signaling. Interruption of this mechanism has been implicated in the dysregulation of many cancer-related pathways, including cell death programs and tumor suppressor networks. Many proteins are known modulators of retrograde signaling, but whether microRNAs (miRNAs) are also involved is unknown. more...
Organism:
Mus musculus; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Homo sapiens; Human polyomavirus 1; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL7724
3 Samples
Download data: TXT, XLSX
Series
Accession:
GSE104277
ID:
200104277
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