txid186634[Organism:exp] - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Search results

Items: 1 to 20 of 46686

<< First< Prev

Page of 2335

Select item 2002254181.

ZNF469 plays a critical role in regulating synthesis of ECM

(Submitter supplied) Purpose: In recent years, the mutation of ZNF469 is considered to be one of the pathogenesis of brittle cornea syndrome（BCS）. We establish a znf469 mutant zebrafish line to explore its phenotype and the possible molecular mechanism. Methods: We generated the znf469 mutant zebrafish by using the CRISPR/Cas9 system. TEM is applied to examine the phenotype of the cornea in different development stage. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24995
6 Samples

Download data: TXT

Series

Accession:: GSE225418

ID:: 200225418

Select item 2001864272.

Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24995
2 Samples

Download data

Series

Accession:: GSE186427

ID:: 200186427

Select item 2002271183.

Transcription factor induction of vascular blood stem cell niches in vivo [scRNA-Seq.Whole-tail]

(Submitter supplied) We report single cell gene expression data for caudal tail tissue cells collected from embryos at 72 hours post fertilization (hpf).

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21741
1 Sample

Download data: TSV

Series

Accession:: GSE227118

ID:: 200227118

Select item 2002271174.

Transcription factor induction of vascular blood stem cell niches in vivo [scRNA-Seq.Embryo-Niche]

(Submitter supplied) We report single cell gene expression data for FACS-isolated zebrafish kdrl(flk1):mCherry and mrc1a.125:GFP double positive cells collected from whole embryos at 72 hours post fertilization (hpf).

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21741
2 Samples

Download data: TSV

Series

Accession:: GSE227117

ID:: 200227117

Select item 2002271155.

Transcription factor induction of vascular blood stem cell niches in vivo [scRNA-Seq.Adult-Kidney]

(Submitter supplied) We report single cell gene expression data for FACS-isolated zebrafish kdrl(flk1):mCherry or kdrl(flk1):GFP positive cells collected from adult kidneys.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21741
3 Samples

Download data: TSV

Series

Accession:: GSE227115

ID:: 200227115

Select item 2002271136.

Transcription factor induction of vascular blood stem cell niches in vivo [ATAC-Seq 2]

(Submitter supplied) We report accessible chromatin genomic regions using ATAC-sequencing of zebrafish double transgenic for kdrl(flk1):mCherry and sele:GFP from FACS-isolated double positive, single positive, and double negative cells collected from whole embryos at 72 hours post fertilization (hpf).

Organism:: Danio rerio

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18413
12 Samples

Download data: NARROWPEAK

Series

Accession:: GSE227113

ID:: 200227113

Select item 2001241517.

Transcription factor induction of vascular blood stem cell niches in vivo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL21741 GPL18413
35 Samples

Download data: TSV

Series

Accession:: GSE124151

ID:: 200124151

Analyze with GEO2R

Select item 2001241508.

Transcription factor induction of vascular blood stem cell niches in vivo [TOMO-Seq]

(Submitter supplied) We report RNA tomography (tomo-seq) gene expression data for the tail region of a 72 hpf zebrafish embryo. The portion of the tail containing the caudal hematopoietic tissue (CHT) was isolated by manual dissection, snap froze, and then cryosections (40 in total, 8 µm-thick) were collected along the dorsal-ventral axis. Each cryosection was placed into a tube and the RNA was exctracted and barcoded during a reverse trancription step prior to library synthesis and sequencing.

Organism:: Danio rerio

Type:: Other

Platform:: GPL18413
1 Sample

Download data: CSV, XLSX

Series

Accession:: GSE124150

ID:: 200124150

Analyze with GEO2R SRA Run Selector

Select item 2001241499.

Transcription factor induction of vascular blood stem cell niches in vivo [scRNA-Seq]

(Submitter supplied) We report single cell gene expression data for FACS-isolated zebrafish kdrl(flk1):GFP positive cells collected from whole embryos at 72 hours post fertilization (hpf).

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
1 Sample

Download data: TSV, TXT, XLS

Series

Accession:: GSE124149

ID:: 200124149

SRA Run Selector

Select item 20012414810.

Transcription factor induction of vascular blood stem cell niches in vivo [RNA-Seq]

(Submitter supplied) We report gene expression data for FACS sorted zebrafish kdrl(flk1):GFP + and kdrl:mCherry+;sele(5.3kb):GFP+ double positive cells collected from whole embryos at 72 hours post fertilization (hpf). We also report gene expression data for the kdrl:GFP negative fraction.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
3 Samples

Download data: XLSX

Series

Accession:: GSE124148

ID:: 200124148

SRA Run Selector

Select item 20012414711.

Transcription factor induction of vascular blood stem cell niches in vivo [ATAC-Seq]

(Submitter supplied) We report ATAC-seq data for FACS sorted zebrafish kdrl(flk1):mCherry+;mrc1a(1.3kb):GFP+ double positive cells collected from whole embryos at 72 hours post fertilization (hpf). We also report ATAC-seq data for the single positive fractions and the remaining, transgene negative, portion of the same embryos. The experiment was performed in triplicate.

Organism:: Danio rerio

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18413
12 Samples

Download data: NARROWPEAK

Series

Accession:: GSE124147

ID:: 200124147

SRA Run Selector

Select item 20022392212.

Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development

(Submitter supplied) We generated an atlas of 489,686 single-cell transcriptomes from 62 closely spaced developmental stages spanning the first 5 days of zebrafish development, encompassing the first transcriptional events after zygotic genome activation to a freely-swimming, feeding animal.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24995
58 Samples

Download data: MTX, TSV, TXT

Series

Accession:: GSE223922

ID:: 200223922

Select item 20022773513.

Transcriptomic profiling of Tg(fabp10a:hUHRF1-EGFP)high zebrafish livers and control siblings at 5 dpf

(Submitter supplied) Overexpression of high levels of human UHRF1 tagged with EGFP (hUHRF1-EGFP)high in zebrafish hepatocytes induces cellular senescence by 5 days post fertilization (dpf) and hepatocellular carcinoma by 15-20 dpf. The goal of this study is to compare the transcriptome profile of zebrafish livers with (hUHRF1-EGFP)high overexpression compared to WT siblings. RNAseq was performed on RNA extracted from pools of microdissected liveres by using RiboZero libary prep to capture all transcripts, including transposable elements, that are expressed in the livers.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25922
11 Samples

Download data: TXT

Series

Accession:: GSE227735

ID:: 200227735

Select item 20018642314.

Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity [Zebrafish.scRNA-seq]

(Submitter supplied) Using a combination of single-cell multi-omics, lineage tracing and functional assays, we show that embryonic HSPCs are originated from heterogeneous hemogenic endothelial cells (HECs) during zebrafish embryogenesis.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24995
2 Samples

Download data

Series

Accession:: GSE186423

ID:: 200186423

SRA Run Selector

Select item 20022755115.

Transcriptomics analysis of a zebrafish model of Combined Saposin Deficiency

(Submitter supplied) Combined Saposin Deficiency is a lysosomal storage disease with multiple-organ pathologies that often involve neurodegeneration and early mortality. To investigate the mechanisms driving saposin loss-associated demyelination, the brains of psap-/- zebrafish and wildtype siblings were analyzed via RNA-seq.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24995
8 Samples

Download data: XLSX

Series

Accession:: GSE227551

ID:: 200227551

Select item 20022413216.

Effect of paternal chronic stress on zebrafish progeny gene expression.

(Submitter supplied) To investigate the potential deleterious impact of chronic stress at molecular level in the progeny, we exposed zebrafish males to an unpredictable chronic stress protocol during 21 days

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24995
8 Samples

Download data: TXT

Series

Accession:: GSE224132

ID:: 200224132

Select item 20021299917.

Effect of chronic stress on zebrafish testicular gene expression

(Submitter supplied) To investigate the potential deleterious impact of chronic stress at molecular level in testicular tissue, we exposed zebrafish males to chronic stress during 21 days, covering around three complete cycles of spermatogenesis in the species

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24995
7 Samples

Download data: TSV

Series

Accession:: GSE212999

ID:: 200212999

Select item 20020557818.

High-throughput Functional Analysis of Autism Genes in Zebrafish Identifies Convergence in Dopaminergic and Neuroimmune Pathways

(Submitter supplied) Investigation of convergence and divergence of different Autism Risk genes at the molecular level, in the brain of zebrafish ASD mutants at 6 days-post-fertilizitation (dpf)

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24995
19 Samples

Download data: CSV

Series

Accession:: GSE205578

ID:: 200205578

Select item 20020508519.

Loss of Glo2 alters the glucose metabolism in zebrafish

(Submitter supplied) Glyoxalase 2 is the second enzyme of the glyoxalase system, catalyzing the detoxification of methylglyoxal to D-lactate via SD-Lactoylglutathione. Recent studies have suggested Glo2 as a regulator of glycolysis, but the physiological functions of Glo2 in vivo and organ specific functions of the enzyme have not yet been evaluated. Therefore, a CRISPR/Cas9 knockout of glo2 in zebrafish was created and analyzed. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24776
12 Samples

Download data: TXT

Series

Accession:: GSE205085

ID:: 200205085

PubMed Full text in PMC Similar studies

Select item 20020057720.

The transcriptome profiling analysis of intestines and kidneys in conventionally raised (CV) and germ-free (GF) wild type zebrafish embryos

(Submitter supplied) To investigate how the zebrafish embryos respond to the absence of the microbiota, the intestinal tissue-associated and the kidney tissue-associated gene expressions were examined at 5 dpf and 7 dpf respectively. 32,948 cDNAs of the zebrafish genome assembly were annotated after reads mapping for further analysis. For the 5 dpf intestinal tissue samples, 948 genes (4% of the total number of genes) were differentially expressed, 371 genes were up-regulated and 577 genes were down-regulated in the GF group . more...