GEO DataSets

(Submitter supplied) Yersinia pestis, the etiologic agent of plague, emerged as a flea-borne pathogen only within the last 6,000 years. Just five simple genetic changes in the Yersinia pseudotuberculosis progenitor, which served to eliminate toxicity to fleas and to enhance survival and biofilm formation in the flea digestive tract, were key to the transition to the arthropod-borne transmission route. To gain a deeper understanding of the genetic basis for the development of a transmissible biofilm infection in the flea foregut, we evaluated additional gene differences and performed in vivo transcriptional profiling of Y. more...

Organism:

Yersinia pestis CO92; Yersinia pseudotuberculosis; Yersinia pestis KIM10+; Yersinia pestis

Type:

Expression profiling by array

Platform:

GPL25510

54 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Yersinia pestis; Yersinia pestis CO92

Type:

Expression profiling by array

Platforms:

GPL10439 GPL9009

48 Samples

Download data: TXT

(Submitter supplied) Quorum sensing is a cell to cell communication process that involves chemical signaling. Yersinia pestis, the agent of plague, has two functional AHL quorum sensing systems Ysp and Ype. For several reasons, it was not clear what effect AHL pathways have on virulence gene expression and survival in the two different hosts, flea and human. To investigate to what effect AHL quorum sensing has on gene expression, we conducted microarray studies comparing Yersinia pestis CO92 (∆pgm) to a double AHL mutant strain (∆pgm ΔypeIR) at 30°C.

Organism:

Yersinia pestis CO92; Yersinia pestis

Type:

Expression profiling by array

Platform:

GPL9009

6 Samples

Download data: TXT

(Submitter supplied) Quorum sensing is a cell to cell communication process that involves chemical signaling. Yersinia pestis, the agent of plague, has two functional AHL quorum sensing systems Ysp and Ype. For several reasons, it was not clear what effect AHL pathways have on virulence gene expression and survival in the two different hosts, flea and human. To investigate to what effect AHL quorum sensing has on gene expression, we conducted microarray studies comparing Yersinia pestis CO92 (∆pgm) to a double AHL mutant strain (∆pgm ΔypeIR ΔyspIR) at 37°C.

Organism:

Yersinia pestis; Yersinia pestis CO92

Type:

Expression profiling by array

Platform:

GPL9009

6 Samples

Download data: TXT

(Submitter supplied) Quorum sensing is a cell to cell communication process that involves chemical signaling. Yersinia pestis, the agent of plague, has two functional AHL quorum sensing systems Ysp and Ype. For several reasons, it was not clear what effect AHL pathways have on virulence gene expression and survival in the two different hosts, flea and human. To investigate to what effect Ysp AHL quorum sensing has on gene expression, we conducted microarray studies comparing Yersinia pestis CO92 (∆pgm) to a single AHL mutant strain (∆pgm ΔyspI) at 30°C.

Organism:

Yersinia pestis; Yersinia pestis CO92

Type:

Expression profiling by array

Platform:

GPL9009

6 Samples

Download data: TXT

(Submitter supplied) Quorum sensing is a cell to cell communication process that involves chemical signaling. Yersinia pestis, the agent of plague, has two functional AHL quorum sensing systems Ysp and Ype. For several reasons, it was not clear what effect AHL pathways have on virulence gene expression and survival in the two different hosts, flea and human. To investigate to what effect Ysp AHL quorum sensing has on gene expression, we conducted microarray studies comparing Yersinia pestis CO92 (∆pgm) to a single AHL mutant strain (∆pgm ΔyspI) at 37°C.

Organism:

Yersinia pestis; Yersinia pestis CO92

Type:

Expression profiling by array

Platform:

GPL9009

6 Samples

Download data: TXT

(Submitter supplied) The etiologic agent of bubonic plague, Yersinia pestis, senses cell density-dependent chemical signals to synchronize transcription between cells of the population in a process named quorum sensing. Though the closely related enteric pathogen Y. pseudotuberculosis uses quorum sensing system to regulate motility, the role of quorum sensing in Y. pestis has been unclear. In this study we performed transcriptional profiling experiments to identify Y. more...

Organism:

Yersinia pestis CO92; Yersinia pestis

Type:

Expression profiling by array

Platform:

GPL9009

6 Samples

Download data: TXT

(Submitter supplied) The study aims to to determine temperature sensitive genes across the strains COW5,PBIB15 and pestoidesF.

Organism:

Yersinia pestis CO92; Yersinia pestis

Type:

Expression profiling by array

Platform:

GPL9009

24 Samples

Download data: MEV

(Submitter supplied) Braun/murein lipoprotein (Lpp) is one of the major outer membrane components of gram-negative bacteria belonging to the enterobacteriaceae family that that is involved in inflammatory responses and septic shock. We previously characterized a delta-lpp isogenic mutant of Yersinia pestis CO92 and found that this mutant was defective in surviving in macrophages and was attenuated in a mouse inhalation model of plague when compared to the highly virulent wild-type (WT) bacterium. more...

Organism:

Yersinia pestis CO92; Yersinia pestis

Type:

Expression profiling by array

Platform:

GPL4201

6 Samples

Download data: GPR

(Submitter supplied) RMLchip8a520720F custom pathogenic Affymetrix chip 8 manufactured for RML Protocol: standard Affymetrix protocol

Organism:

Yersinia pseudotuberculosis; Yersinia pestis KIM10+; Yersinia pestis CO92

1 Series

54 Samples

Download data: CDF, TXT

(Submitter supplied) Yersinia pestis tiling array. Arrays of this design have barcodes that begin with 16027313 or 2527313.. Orientation:. Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software.. The ID column represents the Agilent Feature Extraction feature number.. more...

Organism:

Yersinia pestis CO92

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(Submitter supplied) This set includes 7359 oligonucleotides, has 18240 spots distributed in 48 blocks. Protocol: 5QYP, with arrayer AUSHON, machine cycles 0, pen id 0, pen cycles 0, operator 0, humidity control 0, humidity set point0.000

Organism:

Yersinia pestis CO92

7 Series

54 Samples

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