GEO DataSets

(Submitter supplied) To address the role of miRNAs in Hirschsprund disease (HSCR), we carried out microRNA (miRNA) array analysis by using human intestinal samples obtained from HSCR patients and controls, and identified dysregulated miRNAs involved in the pathogenesis of HSCR.

Organism:

Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Human betaherpesvirus 6B; Homo sapiens; Merkel cell polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL32145

10 Samples

Download data: GPR, TXT

(Submitter supplied) Innate cellular defense mechanisms and viral countermeasures govern the outcome of pathogen exposure but the complex virus-host interplay remains poorly understood. Here, we developed a virus-guided technology platform where the pathogen itself reveals its cellular opponents. To accomplish this, we engineered replication-competent HIV-1 expressing single guide RNAs (sgRNAs) targeting potential antiviral genes in Cas9 expressing CD4+ T cells. more...

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL33848

49 Samples

Download data: TAB, XLSX

(Submitter supplied) The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 subjects were recruited for screening of differentially expressed plasma microRNAs. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and was positively correlated with age. Cell senescence induced the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induced vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. more...

Organism:

Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus hominis; Homo sapiens; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human alphaherpesvirus 2; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL21439

12 Samples

Download data: GPR, XLSX

(Submitter supplied) The analysis of RNA-sequencing data reveals the proportion of the three viruses simultaneously inoculated into humanized mice.

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL23868

17 Samples

Download data: TXT

(Submitter supplied) Excessive alcohol consumption adversely affects the immune system and triggers the activation of peripheral blood (PB) monocytes and tissue macrophages, contributing to alcohol- related organ damage. This study aimed to analyze the M1/M2 and inflammatory phenotypes of circulating monocytes and macrophage-derived monocytes (MDMs). This single-center cross- sectional study included 20 excessive alcohol drinkers (EADs) and 22 healthy controls. more...

Organism:

human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus; Human alphaherpesvirus 2; Merkel cell polyomavirus; Mus musculus cytomegalovirus 2

Type:

Non-coding RNA profiling by array

Platform:

GPL11434

22 Samples

Download data: GPR, TXT

(Submitter supplied) Transcription factor overexpression screen in different cell culture media

Organism:

Lentivirus; Homo sapiens; Escherichia coli

Type:

Other

Platforms:

GPL28126 GPL21697 GPL32884

44 Samples

Download data: CSV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Escherichia coli; Lentivirus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

7 related Platforms

281 Samples

Download data: CSV, MTX, TSV

(Submitter supplied) Chimeric antigen receptor T (CAR-T) cells, long proposed for HIV-1 treatment, has yet to achieve desirable therapeutic efficacy. In our study, M10 CAR-T cells were used for treating 18 HIV-1 patients via a regimen combining two M10 infusions and repeat chidamide stimulation for HIV reservoir activation. Consequently, 74.3% of M10 infusions resulted in significant suppression of viral rebound (averaging 77.4% decline), with 10 patients showing persistently reduced cell-associated HIV-1 RNA levels (averaging > 1.15 log10) over the 150-day observation period. more...

Organism:

Human immunodeficiency virus 1

Type:

Other

Platforms:

GPL32911 GPL32910

26 Samples

Download data: FA, TXT

(Submitter supplied) Silencing of the adaptor SH3BP2 impairs Gastrointestinal stromal tumors growth through miRNAs We dissected SH3BP2 pathway in Gastrointestinal Stromal Tumor cells (GIST) performing a miRNA array in SH3BP2-silenced GIST cells

Organism:

Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Human alphaherpesvirus 2; Betapolyomavirus hominis; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8

Type:

Non-coding RNA profiling by array

Platform:

GPL21599

12 Samples

Download data: TXT, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; dengue virus type 4; Measles morbillivirus; Human immunodeficiency virus 1; Measles virus strain Schwarz

Type:

Expression profiling by high throughput sequencing

5 related Platforms

114 Samples

Download data: TXT

(Submitter supplied) Pattern recognition receptors (PRRs) protect against host invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. While microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation during viral infection remain overlooked. In this work, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors upon infection by a positive-sense RNA virus, a negative-sense RNA virus or a retrovirus. more...

Organism:

Homo sapiens; Human immunodeficiency virus 1

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26693

24 Samples

Download data: TXT

(Submitter supplied) Characterization of pluripotent states, in which cells can both self-renew or differentiate, with the irreversible loss of pluripotency, are important research areas in developmental biology. Although microRNAs (miRNAs) have been shown to be crucial for embryonic stem (ES) self-renewal maintenance and cellular differentiation, the role of miRNAs integrated into gene regulatory networks and its dynamic changes during these state transitions remain elusive. more...

Organism:

Human alphaherpesvirus 2; Murid gammaherpesvirus 4; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Betapolyomavirus hominis; human gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus macacae; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL18658

12 Samples

Download data: TXT

(Submitter supplied) MicroRNAs profile of circulating CD4+ T Cells in Aged Patients with Atherosclerosis Obliterans comparing healthy persons without symptoms or lesion associated with atherosclerosis.

Organism:

Homo sapiens; Rhadinovirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; JC polyomavirus; Human alphaherpesvirus 2; Lymphocryptovirus

Type:

Non-coding RNA profiling by array

Platform:

GPL26002

14 Samples

Download data: GPR, XLSX

(Submitter supplied) By analyzing RNAseq data derived from TCGA and clinical trial in ccRCC we observed that PBRM1 mutation is significantly associated with expression changes of hERVs (human endogenous retroviruses). We validated this observation in UMRC2 cell line and further demonstrated that PBRM1 specifically regulated members of HERVERI superfamily. We found that the increased expression of hERVs by loss of PBRM1 reversed by further knocking down HIF complex. more...

Organism:

Homo sapiens; Human endogenous retroviruses

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30223

12 Samples

Download data: FASTA, TXT

(Submitter supplied) We report deep mutational scanning data for the Env protein's LLP-2 domain in the NL4-3 strain HIV-1 Env. Processed Data repersents counts for each amino acid pre and post spread

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL23868

76 Samples

Download data: TAB

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Human immunodeficiency virus

Type:

Expression profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing

Platforms:

GPL11154 GPL26648

29 Samples

Download data: NARROWPEAK, TXT

(Submitter supplied) In this study, we used a productive HIV infection model, consisting of the CD4+ SupT1 T cell line infected with a VSV-G pseudotyped HIVeGFP-based vector, to explore the transcriptomic and m6A/m5C epitranscriptomic lansdcape upon HIV infection, and compare it to mock-treated cells at 12h, 24h, and 36h post infection.

Organism:

Human immunodeficiency virus

Type:

Other

Platform:

GPL26648

2 Samples

Download data: NARROWPEAK

(Submitter supplied) In this study, we used a productive HIV infection model, consisting of the CD4+ SupT1 T cell line infected with a VSV-G pseudotyped HIVeGFP-based vector, to explore the transcriptomic and m6A/m5C epitranscriptomic lansdcape upon HIV infection, and compare it to mock-treated cells at 12h, 24h, and 36h post infection.

Organism:

Human immunodeficiency virus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL26648

9 Samples

Download data: TXT

(Submitter supplied) Several prior reports have demonstrated that the epitranscriptomic addition of m6A to viral transcripts promotes the replication and pathogenicity of a wide range of viruses yet the underlying mechanism(s) causing this positive effect has remained unclear. It is known that m6A function is largely mediated by cellular m6A binding proteins or readers, however, how these m6A reader proteins contribute to the regulation of HIV-1 gene expression has remained controversial. more...

Organism:

Homo sapiens; Human immunodeficiency virus 1

Type:

Other

Platform:

GPL18160

3 Samples

Download data: BED

(Submitter supplied) We compared histone modifications of wild type and HTLV-1ΔCTCF provirus by ChIP sequencing and observed that loss of the vrial CTCF binding site in HTLV-1 results in increased histone methylation 5’ and 3’ of the CTCF site, suggesting that CTCF binding may act as a boundary element to epigenetic modification.

Organism:

Homo sapiens; Human T-cell leukemia virus type I

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL30008

24 Samples

Download data: BEDGRAPH