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Items: 1 to 20 of 89

1.

Transcriptomic and Metabolomic Analysis Revealed Roles of Yck2 in Carbon Metabolism and Morphogenesis of Candida albicans

(Submitter supplied) Candida albicans is a part of the normal microbiome of human mucosa and is able to thrive in a wide range of host environments. As an opportunistic pathogen, the virulence of C. albicans is tied to its ability to switch between yeast and hyphal morphologies in response to various environmental cues, one of which includes nutrient availability. Thus, metabolic flexibility plays an important role in the virulence of the pathogen. more...
Organism:
Candida albicans SC5314
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27535
6 Samples
Download data: XLSX
Series
Accession:
GSE138069
ID:
200138069
2.

Transcriptome analysis of C. albicans response to mucin from porcine stomach

(Submitter supplied) An RNA-Seq study was undertaken to compare the global response of the fungus C. albicans to intestinal mucin (compared to control medium and medium containing glucose).
Organism:
Candida albicans SC5314
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28448
6 Samples
Download data: TXT
Series
Accession:
GSE149196
ID:
200149196
3.

Relative roles of Stp1 and Stp2 in amino acid and peptide utilization in Candida albicans

(Submitter supplied) Candida albicans is a member of the normal commensal flora with the ability to cause disease in susceptible individuals. Nutrient acquisition is of central importance for C. albicans to colonize and thrive in the host. We have previously assessed the role of amino acid utilization for growth and manipulation of pH, triggering the filamentation program and promoting immune evasion. While the role of amino acids has been largely studied, protein utilization has remained less well understood. more...
Organism:
Candida albicans SC5314
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28174
27 Samples
Download data: TXT
Series
Accession:
GSE145576
ID:
200145576
4.

Candida albicans Cells: Control vs. BDSF (Cis-2-dodecenoic acid) treatment

(Submitter supplied) Cis-2-dodecenoic acid (BDSF), a signalling molecule produced from burkholderia cenocepanic, can prevent C. albicans hyphal and biofilm formation. The mechanism of how BDSF controls C. albicans morphological switch is still unknown. To address this issue, we used DNA microarray method to investigate the changes in gene expression before and after BDSF treatment. Further, screening a mutant library based on microarray data was carried out to find the mutants unresponding to BDSF.
Organism:
Candida albicans SC5314
Type:
Expression profiling by array
Platform:
GPL27468
2 Samples
Download data: LSR, XLSX
Series
Accession:
GSE137546
ID:
200137546
5.

Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Candida albicans; Candida albicans SC5314
Type:
Expression profiling by array; Genome variation profiling by array
Platforms:
GPL19026 GPL19049
19 Samples
Download data: TXT
Series
Accession:
GSE60122
ID:
200060122
6.

Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans [CGH]

(Submitter supplied) The fungal pathogen Candida albicans and other pathogens of the CTG clade reassigned the leucine CUG codon to serine and tolerate highly variable levels of both serine and leucine at CUG positions in response to environmental cues. Previous studies found that increased leucine misincorporation levels enhance resistance to drugs but the underlying mechanisms are not known. To clarify the biological role of this tuneable codon ambiguity, we evolved C. more...
Organism:
Candida albicans SC5314; Candida albicans
Type:
Genome variation profiling by array
Platform:
GPL19026
3 Samples
Download data: TXT
Series
Accession:
GSE60120
ID:
200060120
7.

Dermal fibroblasts play a central role in skin model protection against C. albicans invasion

(Submitter supplied) This study shows that, in the presence of CD4+ T cells, dermal fibroblasts shift towards an antimicrobial phenotype leading to reduced dermal invasion by C. albicans. This is dependent on TLR2 activation and pro-IL-1β cleavage and results in expression of genes involved in defense against various classes of pathogens.
Organism:
Candida albicans SC5314; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL22432 GPL16791
18 Samples
Download data: TXT
Series
Accession:
GSE86926
ID:
200086926
8.

Antifungal effect of Perillyl alcohol (PA) on C. albicans SC5314

(Submitter supplied) Transcriptional profiling of Candida cells comparing the control vs PA treated cells
Organism:
Candida albicans SC5314; Candida albicans
Type:
Expression profiling by array
Platform:
GPL21258
5 Samples
Download data: TXT
Series
Accession:
GSE76383
ID:
200076383
9.

An antifungal benzimidazol reveals novel sterols after inhibition of Erg11.

(Submitter supplied) Fungal infections are a serious health problem in clinics especially in the immune-compromised patient. Disease ranges from widespread superficial infections like vulvovaginal infections to life-threatening systemic candidiasis. Especially for systemic mycoses only a limited arsenal of antifungals is available. The most commonly used classes of antifungal compounds used include azoles, polyenes and echinocandines. more...
Organism:
Candida albicans SC5314; Candida albicans
Type:
Expression profiling by array
Platform:
GPL10374
18 Samples
Download data: GPR
Series
Accession:
GSE64976
ID:
200064976
10.

Comparative xylose metabolism among the ascomycetes C. albicans, S. stipitis and S. cerevisiae

(Submitter supplied) The ascomycetes Saccharomyces cerevisiae, Candida albicans and Scheffersomyces stipitis metabolize the pentose sugar xylose very differently. S. cerevisiae fails to grow on xylose, while C. albicans can grow, and S. stipitis can both grow and ferment xylose to ethanol. However, all three species contain highly similar genes that encode xylose reductase and xylitol dehydrogenase required to convert xylose to xylulose, on which all three fungi grow. more...
Organism:
Candida albicans; Saccharomyces cerevisiae; Candida albicans SC5314
Type:
Expression profiling by array
Platforms:
GPL13945 GPL9818
9 Samples
Download data: TXT
Series
Accession:
GSE50476
ID:
200050476
11.

A family of secreted pathogenesis-related proteins in Candida albicans

(Submitter supplied) Analyzing culture supernatants of yeast and hyphal cells of Candida albicans by mass spectrometry, we found two close homologues of pathogenesis-related (PR-) 1 proteins, Rbe1p and Rbt4p, in the secretome of this human pathogen. By sequence homology, we assigned three yet not characterized open reading frames, ORF19.6200, ORF19.2787 and ORF19.2336, in addition to Rbe1p and Rbt4p to a novel family of proteins. more...
Organism:
Candida albicans SC5314; Candida albicans
Type:
Expression profiling by array
Platform:
GPL10374
12 Samples
Download data: GPR
Series
Accession:
GSE28212
ID:
200028212
12.

Effect of fludioxonil treatment on candida albicans SC5314

(Submitter supplied) Comparison of Candida albicans SC5314 treated with fludioxonil for 30 min and untreated controls under hyphae-inducing conditions
Organism:
Candida albicans SC5314; Candida albicans
Type:
Expression profiling by array
Platform:
GPL15859
6 Samples
Download data: TXT
Series
Accession:
GSE39715
ID:
200039715
13.

Response of Candida albicans towards a novel antifungal benzimidazole derivative

(Submitter supplied) Fungal infections are a serious health problem in the clinic especially in the immunocompromised patient. Disease ranges from widespread superficial vulvovaginal infections to life-threatening systemic candidiasis. Especially for systemic mycoses only a limited arsenal of antimycotica are available, including azoles, polyenes, echinocandines and amphothericin B. Due to emerging resistance to standard therapy and significant side effects for some antimycotica there is a medical need for new antifungals in the clinic and general practice. more...
Organism:
Candida albicans SC5314; Candida albicans
Type:
Expression profiling by array
Platform:
GPL10374
6 Samples
Download data: GPR
Series
Accession:
GSE21622
ID:
200021622
14.

Transciptional profiling of Candida albicans wild-type strains with TRK1 gene modification

(Submitter supplied) We built 3 strains from Candida albicans wild-type strains, mutant strain with one TRK1 gene deleted(one allele of two genes was deleted), overexpression strain(add one allele of the gene to rp10 locus), and restoration strain(add one allele of the gene to mutant strains). The goal is study the expression level change of genes among the three strains compared with wild-type strain on a genomic scale. more...
Organism:
Candida albicans; Candida albicans SC5314
Type:
Expression profiling by array
Platform:
GPL4920
12 Samples
Download data: GPR
Series
Accession:
GSE8475
ID:
200008475
15.

Transcriptional profiling of Candida albicans wild-type CAI-4 strans treated by Hst5

(Submitter supplied) The experiment was designed to study the transcriptional profiling of Candida albicans wild-type CAI-4 strains and corresponding Histatin 5 treated strains. Since Histatin 5 will kill Candida albicans, the focus will be on how many and which genes are significantly affected with the treatment of Histatin 5. Currently, we only conducted the microarray experiments at one concentration of Histatin 5 and one time point of treatment. more...
Organism:
Candida albicans; Candida albicans SC5314
Type:
Expression profiling by array
Platform:
GPL4920
4 Samples
Download data: GPR
Series
Accession:
GSE8473
ID:
200008473
16.

Illumina HiSeq 2000 (Candida albicans SC5314)

Organism:
Candida albicans SC5314
1 Series
6 Samples
Download data
Platform
Accession:
GPL28448
ID:
100028448
17.

NextSeq 550 (Candida albicans SC5314)

Organism:
Candida albicans SC5314
1 Series
27 Samples
Download data
Platform
Accession:
GPL28174
ID:
100028174
18.

Illumina HiSeq 2500 (Candida albicans SC5314)

Organism:
Candida albicans SC5314
1 Series
6 Samples
Download data
Platform
Accession:
GPL27535
ID:
100027535
19.

CapitalBio 8K Candida albicans genome array

(Submitter supplied) There is 7925 70-mer oligonucleotides in the 8 K C. albicans genome array and the oligo library (C.albicans Genome Oligo Set Version 1.1) can be retrieved from Operon corporation (http://www.operon.com). Then oligo library was pointed to a 75×25 mm chemically modified glass slide using a SmartArrayTM (CapitalBio Corp., Beijing, China) and the location of the genes on the chip can be found in "gene list.xlsx".
Organism:
Candida albicans SC5314
1 Series
2 Samples
Download data: XLSX
Platform
Accession:
GPL27468
ID:
100027468
20.

Agilent-038464 CaSC5314_SnpCgh_v1_Santos 033626

(Submitter supplied) Arrays of this design have barcodes that begin with 16038464 or 2538464. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Feature Extraction feature number. Rows and columns are numbered as scanned by an Axon Scanner (barcode on the bottom, DNA on the front surface). more...
Organism:
Candida albicans SC5314
2 Series
3 Samples
Download data: TXT
Platform
Accession:
GPL19026
ID:
100019026
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