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Items: 1 to 20 of 4509762

1.

Gene expression profile of E15.5 Pantr2 knockout dorsal telencephalon

(Submitter supplied) We used single nuclei RNA sequencing to discover changes in the developmental trajectory of differentiating neural precusors in the developing murine cortex
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data: CSV, MTX
Series
Accession:
GSE210572
ID:
200210572
2.

Transcriptome data of bone marrow regulatory T cells (Tregs) with aging

(Submitter supplied) Bone marrow (BM) is normally maintained in an immune-privileged and anti-inflammatory state, kept in check principally by regulatory T cells (Tregs). Thus, it is reasonable to expect that Tregs will help shield hematopoietic stem cells (HSCs) from excessive inflammation and thereby counteract HSC aging. Understanding how BM Tregs are adapted to the aged BM and whether they are endowed with unique functions to modulate HSC aging will identify targets for prevention of HSC aging. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE210533
ID:
200210533
3.

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice exposed to irradiation

(Submitter supplied) Analysis of MHCII-high (MHCII-hi) and MHCII-low (MHCII-lo) hematopoietic stem cells (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-). The two population of hematopoietic stem cell (HSC) were purified from the bone marrow of mice 3 months post 5 Gy total body irradiation (IR). Results provide insight into the role of MHCII in HSC.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE210532
ID:
200210532
4.

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of middle-aged mice

(Submitter supplied) Analysis of MHCII-high (MHCII-hi) and MHCII-low (MHCII-lo) hematopoietic stem cells (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-). The two population of hematopoietic stem cell (HSC) were purified from the bone marrow of 12 months old (12 mo) mice. Results provide insight into the role of MHCII in HSC.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE210531
ID:
200210531
5.

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice under homeostasis

(Submitter supplied) Analysis of MHCII-high (MHCII-hi) and MHCII-low (MHCII-lo) hematopoietic stem cells (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-). The two population of hematopoietic stem cell (HSC) were purified from the bone marrow of 2 months old (2 mo) mice. Results provide insight into the role of MHCII in HSC.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE210530
ID:
200210530
6.

Transcriptome data of bone marrow hematopoietic stem cells (HSCs) with aging

(Submitter supplied) HSC aging is a well-described paradigm for the investigation of stem cell aging. However, the mechanistic interrelationships and hierarchical orders of these characters of HSC aging have not yet been clarified. To identify the underlying mechanisms and phenotype switching in HSC aging, we performed RNA-seq of HSCs from the bone marrow (BM) of mice at 2 mouths old (2 mo) and 12 mouths old (12 mo).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE210529
ID:
200210529
7.

Diverse development potency and metabolic shape of extended pluripotency are faithfully transferred to somatic cells via cell fusion reprogramming

(Submitter supplied) Extended pluripotent stem cells (EPSCs) are a novel cell type derived from 8-cell stage embryo or conversion of pluripotent stem cells using a chemical cocktail that blocks the cell fate decision. Previous studies have defined various aspects of EPSCs including dual differentiational potency to both extraembryonic and embryonic lineages, their ability to directly transfer extended pluripotency to differentiated somatic cells by cell fusion remains unelucidated. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL17021
8 Samples
Download data: TXT
Series
Accession:
GSE210520
ID:
200210520
8.

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (P5 parietal bone)

(Submitter supplied) We used single cell RNA sequencing (scRNA-seq) to identify parietal osteoblast cell stress response pathway to misfolding of type I procollagen with Gly610->Cys substitution in the triple helical region of alpha2(I) chain.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
8 Samples
Download data: H5, HTML, MTX, TSV
Series
Accession:
GSE210519
ID:
200210519
9.

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (E18.5 femur and tibia)

(Submitter supplied) We used single cell RNA sequencing (scRNA-seq) to identify femur and tibia osteoblast cell stress response pathway to misfolding of type I procollagen with Gly610->Cys substitution in the triple helical region of alpha2(I) chain.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
10 Samples
Download data: H5, HTML, MTX, TSV
Series
Accession:
GSE210511
ID:
200210511
10.

Gene expression profiles of control/normoxia and Sox17i∆EC/hypoxia in EC-specific RiboTag mouse

(Submitter supplied) To understand molecular changes underlying vascular pathology initiated by endothelial Sox17 deficiency, we performed endothelial-specific transcriptomic profiling using highly endothelial-enriched transcripts from the lung of control and Sox17i∆EC/hypoxic mice
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
8 Samples
Download data: TXT, XLSX
Series
Accession:
GSE210505
ID:
200210505
11.

Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells

(Submitter supplied) Neutrophilic asthma is associated with disease severity and corticosteroid insensitivity. Novel therapies are required to manage this life-threatening asthma phenotype. Programmed cell death protein-1 (PD-1) is a key homeostatic modulator of the immune response for T cell effector functions. Our study was conducted to assess the therapeutic potential of a novel human PD-1 agonist in a humanized mouse model in which the PD-1 extracellular domain is entirely humanized. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
6 Samples
Download data: TXT
Series
Accession:
GSE210349
ID:
200210349
12.

Pan-cancer single-cell analysis reveals the key role of cancer-associated fibroblasts in the tumor microenvironment

(Submitter supplied) Cancer-associated fibroblasts (CAFs) are the dominant components of stroma in the tumor microenvironment (TME), and they influence cancer hallmarks by interacting with other TME components. However, the heterogeneity and dynamics of CAFs have not been systematically characterized across different cancer types. Here, we performed pan-cancer analysis on 226 samples from 164 donors across 10 types of solid cancers to profile the TME at single-cell resolution. more...
Organism:
Homo sapiens
Type:
Third-party reanalysis
Download data: RDS, TXT, XLS
Series
Accession:
GSE210347
ID:
200210347
13.

Identification and Characterization of a MAPT-targeting Locked Nucleic Acid Antisense Oligonucleotide Therapeutic for Tauopathies III

(Submitter supplied) Tau is a microtubule-associated protein (MAPT, tau) implicated in the pathogenesis of Tauopathies, a spectrum of neurodegenerative disorders characterized by accumulation of hyperphosphorylated, aggregated tau.  Because tau pathology can be distinct across diseases, a pragmatic therapeutic approach may be to intervene at the level of the tau transcript, as it makes no assumptions to mechanisms of tau toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
1 Sample
Download data: BAI, BAM
Series
Accession:
GSE209747
ID:
200209747
14.

Transcriptome response to anti-hormonals in Esr1 and CYP19A1 genetically engineered mouse models of breast cancer risk during reproductive senescence

(Submitter supplied) Reproductive senescence is an age-associated process in which reproductive capacity is reduced. In female mice this is associated with loss of oocytes and a corresponding reduction in ovarian estrogen production. Normal mammary gland development and function is linked to estrogen stimulation. In this study we utilize two genetically engineered mouse models of breast cancer risk, one with mammary-targeted conditional expression of Esr1, the RNA that encodes Estrogen Receptor alpha, and one with mammary-targeted conditional expression of CYP19A1, the RNA that encodes Aromatase, the enzyme that is responsible for estrogen synthesis from androgens to determine how reproductive senescence impacts the transcriptional response to commonly used anti-hormonals employed for breast cancer prevention, tamoxifen and letrozole. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL21626
24 Samples
Download data
Series
Accession:
GSE201326
ID:
200201326
15.

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III

(Submitter supplied) Here we analyze the transcriptional profiles of homogenized lungs resected from young female APOE2, APOE3, and APOE4 knock-in mice on day 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
23 Samples
Download data
Series
Accession:
GSE200132
ID:
200200132
16.

scRNAseq of lungs from APOE knock-in mice with COVID-19

(Submitter supplied) We performed single cell RNA-sequencing of lungs from APOE knock-in mice in the absence of infection or four days post infection with SARS-CoV-2 MA10. Infected mice showed major remodeling of the cellular composition with expansion of myeloid cells and relative depletion of epithelial cells. In infected mice, APOE2 mice showed enrichment of pathways implicated in immune activation, consistent with immunologic misfiring.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
1 Sample
Download data: CSV, MTX, TSV, TXT
Series
Accession:
GSE199498
ID:
200199498
17.

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
86 Samples
Download data
Series
Accession:
GSE184289
ID:
200184289
18.

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 II

(Submitter supplied) Here we analyze the transcriptional profiles of homogenized lungs resected from APOE2, APOE3, and APOE4 knock-in mice on day 4 post infection with SARS-CoV-2 MA10. This experiment validated a prior RNA-seq experiment revealing blunted adaptive immunity in APOE2 and APOE4 mice during COVID-19 progression.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
24 Samples
Download data
Series
Accession:
GSE184288
ID:
200184288
19.

RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I

(Submitter supplied) Here we analyze the transcriptional profiles of homogenized lungs resected from APOE2, APOE3, and APOE4 knock-in mice in the absence of infection (day 0) and on days 2 and 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
39 Samples
Download data
Series
Accession:
GSE184287
ID:
200184287
20.

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma (Digital Spatial Profiling)

(Submitter supplied) To progress, tumors need to invade the surrounding tissues. However, the heterogeneity of cell types at the tumor-stroma interface and the complexity of their potential interactions hampered mechanistic insights for efficient therapeutic targeting. Here, combining single-cell and spatial transcriptomics on human basal cell carcinomas (BCCs), we define the cellular contributors of the invasive front. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL32550
95 Samples
Download data: DCC
Series
Accession:
GSE210648
ID:
200210648
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