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Items: 1 to 20 of 65212

1.

Maternal Adiposity Alters Transcriptomic and Epigenomic Neurodevelopmental Landscapes in the Fetal Hippocampus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Papio anubis
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL30489 GPL33441
50 Samples
Download data: TXT
Series
Accession:
GSE233729
ID:
200233729
2.

Maternal Adiposity Alters Transcriptomic and Epigenomic Neurodevelopmental Landscapes in the Fetal Hippocampus (RNA-Seq)

(Submitter supplied) To investigate the effects of maternal adiposity and leptin on fetal brain development, fetal hippocampal brain tissue was collected at 0.9 term for bulk RNA Seq analysis
Organism:
Papio anubis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30489
8 Samples
Download data: TXT
Series
Accession:
GSE233724
ID:
200233724
3.

Maternal Adiposity Alters Transcriptomic and Epigenomic Neurodevelopmental Landscapes in the Fetal Hippocampus (Targeted EM-Seq)

(Submitter supplied) To investigate the effects of maternal adiposity and leptin on fetal brain development, fetal hippocampal brain tissue and DNA was collected at 0.9 term for targeted EM-Seq analysis
Organism:
Papio anubis
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL33441
24 Samples
Download data: TXT
Series
Accession:
GSE233721
ID:
200233721
4.

Maternal Adiposity Alters Transcriptomic and Epigenomic Neurodevelopmental Landscapes in the Fetal Hippocampus (Bisulfite-Seq)

(Submitter supplied) To investigate the effects of maternal adiposity and leptin on fetal brain development, fetal hippocampal brain tissue and DNA was collected at 0.9 term for targeted EM-Seq analysis
Organism:
Papio anubis
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL30489
18 Samples
Download data: TXT
Series
Accession:
GSE233720
ID:
200233720
5.

Vaccinia virus infection induces concurrent alterations in host chromatin architecture, accessibility, and gene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Chlorocebus sabaeus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing
Platforms:
GPL30937 GPL28836
36 Samples
Download data: BW
Series
Accession:
GSE248052
ID:
200248052
6.

Vaccinia virus infection induces concurrent alterations in host chromatin architecture, accessibility, and gene expression [RNA-seq]

(Submitter supplied) Genomic DNA folds into complex configurations that produce particular local and globalstructures thought to profoundly impact genome function. To understand the dynamic nature ofthis relationship, we investigated the extent of host chromatin structural and functional changesin response to a viral agent. We performed comprehensive assessments of host architecture (Hi-C), accessibility (ATAC-seq), and gene expression (RNA-seq) in a paired manner in response toattenuated vaccinia (smallpox) virus. more...
Organism:
Chlorocebus sabaeus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28836
12 Samples
Download data: BW, CSV
Series
Accession:
GSE248050
ID:
200248050
7.

Vaccinia virus infection induces concurrent alterations in host chromatin architecture, accessibility, and gene expression [Hi-C]

(Submitter supplied) Genomic DNA folds into complex configurations that produce particular local and globalstructures thought to profoundly impact genome function. To understand the dynamic nature ofthis relationship, we investigated the extent of host chromatin structural and functional changesin response to a viral agent. We performed comprehensive assessments of host architecture (Hi-C), accessibility (ATAC-seq), and gene expression (RNA-seq) in a paired manner in response toattenuated vaccinia (smallpox) virus. more...
Organism:
Chlorocebus sabaeus
Type:
Other
Platform:
GPL30937
12 Samples
Download data: HIC
Series
Accession:
GSE248049
ID:
200248049
8.

SIV infection and ARV treatment reshape the transcriptional and epigenetic profile of naïve and memory T cells in vivo (RNA-Seq)

(Submitter supplied) Here we use RNAseq and ATACseq to study the transcriptomics and epigenetic landscape of longitudinally sampled naïve and memory CD4+ and CD8+ T cells in two species of non-human primates prior to SIV infection, during chronic SIV infection, and after administration of ARVs. We find that SIV infection leads to significant alteration to the transcriptomic profile of all T cell subsets that are only partially reversed by administration of ARVs. more...
Organism:
Macaca nemestrina; Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL27943 GPL33261
116 Samples
Download data: TXT
Series
Accession:
GSE264657
ID:
200264657
9.

SIV infection and ARV treatment reshape the transcriptional and epigenetic profile of naïve and memory T cells in vivo (ATAC-Seq)

(Submitter supplied) Here we use RNAseq and ATACseq to study the transcriptomics and epigenetic landscape of longitudinally sampled naïve and memory CD4+ and CD8+ T cells in two species of non-human primates prior to SIV infection, during chronic SIV infection, and after administration of ARVs. We find that SIV infection leads to significant alteration to the transcriptomic profile of all T cell subsets that are only partially reversed by administration of ARVs. more...
Organism:
Macaca mulatta; Macaca nemestrina
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL33261 GPL27943
120 Samples
Download data: BW, NARROWPEAK
Series
Accession:
GSE264656
ID:
200264656
10.

Vaccinia virus infection induces concurrent alterations in host chromatin architecture, accessibility, and gene expression [ATAC-seq]

(Submitter supplied) Genomic DNA folds into complex configurations that produce particular local and globalstructures thought to profoundly impact genome function. To understand the dynamic nature ofthis relationship, we investigated the extent of host chromatin structural and functional changesin response to a viral agent. We performed comprehensive assessments of host architecture (Hi-C), accessibility (ATAC-seq), and gene expression (RNA-seq) in a paired manner in response toattenuated vaccinia (smallpox) virus. more...
Organism:
Chlorocebus sabaeus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL30937
12 Samples
Download data: BW
Series
Accession:
GSE248048
ID:
200248048
11.

Cynomolgus macaques: Young vs Elder

(Submitter supplied) Transcriptional profiling of cynomolgus macaques liver tissue comparing control young macaques with elder macaques. Goal was to determine the liver genetic change with aging of macaques.
Organism:
Macaca fascicularis
Type:
Expression profiling by array
Platform:
GPL26395
13 Samples
Download data: CSV, TXT
Series
Accession:
GSE200368
ID:
200200368
12.

Immunotyping of microglia and macrophages in the CNS during acute SIV infection: a single-cell study of rhesus macaque brains

(Submitter supplied) Human immunodeficiency virus (HIV) is widely recognized for its striking impact on the immune system. Even though HIV is primarily known for the impairment of the peripheral CD4 T cells, its influence on the central nervous system (CNS) also cannot be neglected. The main immune constituents in the brain, microglia and macrophages, are the target for HIV in the brain, as well as for the simian immunodeficiency virus (SIV) in nonhuman primates. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL29319 GPL27943
20 Samples
Download data: H5
Series
Accession:
GSE253835
ID:
200253835
13.

Preclinical study on safety and efficacy of GMP human umbilical cord mesenchymal stem cells in knee osteoarthritis

(Submitter supplied) Clinical trials of MSCs in the treatment of OA have been carried out and good results have been obtained. However, these data on the dose of transplanted cells, the number of transplants, the therapeutic effect especially cartilage regeneration and safety are incomplete. Therefore, we constructed a cynomolgus macaque model consistent with the pathogenesis of OA. We have also established clinical-grade human umbilical cord-derived mesenchymal stem cell line. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28212
30 Samples
Download data
Series
Accession:
GSE250569
ID:
200250569
14.

Natural killer cell receptor expressing B cells: a distinct but rare subset of innate immune cells in rhesus macaques

(Submitter supplied) Natural killer-like B (NKB) cells are unique innate immune cells that express both natural killer (NK) and B cell markers. They act as first responders by secreting IL-18 upon infection, thus inducing the critical cascade of innate and adaptive immune cell infiltration and activation. However, limited research exists on the role of NKB cells in homeostasis, and infection in primates. Therefore, we investigated the signaling and trafficking proteome, in situ localization and transcriptome of NKB cells in comparison to conventionally defined NK and B cells. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27943
314 Samples
Download data: TXT
Series
Accession:
GSE263399
ID:
200263399
15.

Atlas of Cynomolgus Macaque Hematopoiesis

(Submitter supplied) Self-renewal and differentiation are inherent properties of hematopoietic stem cells that are necessary to support hematopoiesis. However, the underlying mechanisms, especially in human, remain unclear. Here, using the cynomolgus macaque as a surrogate model, we develop a new gating strategy to isolate with high purity transplantable cynomolgus HSCs and generated a single-cell transcriptomic map of cynomolgus HSCs and progenitor cells, that covers the gestational period not analyzed in human. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28212
36 Samples
Download data: MTX, TSV
Series
Accession:
GSE262140
ID:
200262140
16.

Position-dependent function of human sequence-specific transcription factors

(Submitter supplied) Patterns of transcriptional activity are encoded in our genome through regulatory elements such as promoters or enhancers that, paradoxically, often contain similar assortments of sequence-specific transcription factor (TF) binding sites. Knowledge of how these sequence motifs encode multiple, often overlapping gene expression programs is central to understanding gene regulation and how mutations in non-coding DNA manifest in disease. more...
Organism:
Homo sapiens; Mus musculus; Chlorocebus sabaeus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
4 related Platforms
56 Samples
Download data: BED, FA, TSV, TXT
Series
Accession:
GSE199431
ID:
200199431
17.

Transcriptome sequencing from rhesus macaque cell lines

(Submitter supplied) Non-human primate (NHP)-based model systems are highly relevant for biomedical research. However, only few NHP cell lines are available and the generation of additional cell lines is an urgent need to help in the refinement and replacement of these models. Using lentiviral transduction of c-Fos, we established cell lines from the brain of rhesus macaques (Macaca mulatta). Transcriptome analysis revealed that these cell lines are closely related to astrocytes, which was confirmed by Western blot detecting expression of the astrocyte marker glial fibrillary acidic protein (GFAP). more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23949
4 Samples
Download data: CSV, TXT
Series
Accession:
GSE241295
ID:
200241295
18.

Chronic alcohol drinking modulates synchrony between midbrain gene transcription and long-lasting changes in dopamine terminal and opioid function in macaques

(Submitter supplied) Alcohol use disorder is marked by disrupted behavioral and emotional states which can persist into abstinence. The enduring synaptic alterations that remain despite the absence of alcohol are of interest for interventions to prevent relapse. 28 male rhesus macaques underwent over 20 months of alcohol drinking interspersed with three 30-day forced abstinence periods. After the last abstinence period, we paired ex vivo voltammetry in nucleus accumbens slices with RNA-sequencing of the ventral tegmental area. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27943
28 Samples
Download data: CSV, XLSX
Series
Accession:
GSE244557
ID:
200244557
19.

Dysregulation of Neuroprotective Lipoxin Pathway in Astrocytes in Response to Cytokines and Ocular Hypertension

(Submitter supplied) Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B4 (LXB4), produced by retinal astrocytes, has direct neuroprotective actions on retinal ganglion cells. In this study, we aimed to investigate how the autacoid LXB4 influences astrocyte reactivity in the retina under inflammatory cytokine-induced activation and ocular hypertension conditions. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27943
2 Samples
Download data: CSV
Series
Accession:
GSE241131
ID:
200241131
20.

Translational Insights from Cell-type variation across Amygdala Subnuclei in Rhesus Monkeys and Humans

(Submitter supplied) Theories of amygdala function are central to our understanding of psychiatric and neurodevelopmental disorders. However, our limited knowledge of the molecular and cellular composition of the amygdala impedes translational research aimed at developing new treatments and interventions. Here, we use single-nucleus RNA-sequencing from multiple amygdala subnuclei in both humans (n=3, Male) and rhesus macaques (n=3, Male) to begin to bridge the gap between preclinical rodent models and human disorders. more...
Organism:
Macaca mulatta; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32794
1 Sample
Download data: H5AD, XLSX
Series
Accession:
GSE262905
ID:
200262905
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