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Items: 1 to 20 of 112

1.

Tick Adiponectin Receptor-Mediated Phospholipid Metabolism Contributes to Borrelia burgdorferi Colonization

(Submitter supplied) Tick gut global gene expression change after silencing adiponectin receptor
Organism:
Ixodes scapularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29893
12 Samples
Download data: TXT
Series
Accession:
GSE169293
ID:
200169293
2.

RNA-dependent RNA polymerases in the black-legged tick produce Argonaute-dependent small RNAs and regulate genes

(Submitter supplied) Small regulatory RNAs (sRNAs) are involved in anti-viral defense and gene regulation. Although RNA-dependent RNA Polymerases (RdRPs) play essential roles in sRNA biogenesis in nematodes, plants and fungi, their involvement in other animals remains controversial. We identify abundant classes of ~22nt sRNAs that require specific combinations of RdRPs and sRNA effector proteins (Argonautes or AGOs) expressed in the tick ISE6 cell line. more...
Organism:
Ixodes scapularis
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL30611 GPL18496
25 Samples
Download data: XLSX
Series
Accession:
GSE183810
ID:
200183810
3.

Lizard feeding enhances Ixodes pacificus vector competence

(Submitter supplied) Ixodes pacificus, the vector of Borrelia burgdorferi (Bb) on the west coast, feeds on a variety of hosts including rodents, birds, and lizards. While rodents are reservoirs for Bb and can infect juvenile ticks, lizards are Bb-refractory. Despite the range of bloodmeals for I. pacificus, it is undetermined how larval host bloodmeal identity may affect future nymphal vector competence. Here, we conducted a transcriptome analysis on I. more...
Organism:
Ixodes pacificus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30030
18 Samples
Download data: GTF, TXT
Series
Accession:
GSE173109
ID:
200173109
4.

Tick-borne Pathogens Induce Differential Expression of Genes Promoting Cell Survival and Host Resistence in Ixodes ricinus Cells

(Submitter supplied) There has been an emergence and expansion of tick-borne diseases in Europe, Asia and North America in recent years, including Lyme disease, tick-borne encephalitis, and human anaplasmosis. The primary tick vectors implicated are hard ticks of the Ixodes genera. Although much is known about the host response to these bacterial and viral pathogens, there is limited knowledge of the cellular responses to infection within the tick vector. more...
Organism:
Ixodes ricinus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21340
6 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE85300
ID:
200085300
5.

Tissue-specific signatures in the transcriptional response to Anaplasma phagocytophilum infection of Ixodes scapularis and Ixodes ricinus tick cell lines

(Submitter supplied) We report differential gene expression with tissue-specific signatures in tick cell lines infected with Anaplasma phagocytophilum - transcriptional response to infection of I. scapularis ISE6 cells resembled that of tick hemocytes while the response in I. ricinus IRE/CTVM20 cells resembles that of tick midguts.
Organism:
Ixodes ricinus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21340
4 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE76906
ID:
200076906
6.

Effect of Anaplasma phagocytophilum infection on the micro RNA profile of Ixodes scapularis tick cells

(Submitter supplied) Ticks are blood feeding arthropod ectoparasites that transmit pathogens, which cause diseases in humans and animals worldwide. In the past ten decades, the continuous human exploitation of environmental resources and the increase in human outdoor activities has promoted contact with arthropod vectors normally present in the wild, resulting in increased transmission of vector-borne pathogens. In addition, vector populations are expanding in response to climate change and human interventions that impact reservoir host movement and human exposure to infected vectors. more...
Organism:
Ixodes scapularis
Type:
Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL21603
4 Samples
Download data: GTF
Series
Accession:
GSE79324
ID:
200079324
7.

Integrated metabolomics, transcriptomics and proteomics identifies metabolic pathways affected by Anaplasma phagocytophilum infection in tick cells

(Submitter supplied) Anaplasma phagocytophilum is an emerging zoonotic pathogen that causes human granulocytic anaplasmosis. These intracellular bacteria establish infection by affecting cell function in both the vertebrate host and the tick vector, Ixodes scapularis. Previous studies have characterized the tick transcriptome and proteome in response to A. phagocytophilum infection. However, in the post-genomic era, the integration of omics datasets through a systems biology approach allows network-based analyses to describe the complexity and functionality of biological systems such as host-pathogen interactions and the discovery of new targets for prevention and control of infectious diseases. more...
Organism:
Ixodes scapularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18496
4 Samples
Download data: GTF
Series
Accession:
GSE68881
ID:
200068881
8.

High throughput sequencing of B.henselae infected and non-infected I. ricinus salivary glands

(Submitter supplied) In order to select genes that are differentially expressed in salivary glands during Ixodes ricinus infection by Bartonella henselae we compare the transcriptome of infected and non-infected salivary glands
Organism:
Ixodes ricinus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18567 GPL18566
3 Samples
Download data: TSV, TXT
Series
Accession:
GSE56746
ID:
200056746
9.

Comparison of Transcriptome Profiles of Human Ehrlichiosis Agents

(Submitter supplied) This study is to determine and compare the transcriptomes in two eukaryotic hosts (mammalian host - DH82 canine cell line and tick vector - ISE6 Ixodes scapularis cell line) of eight Ehrlichia chaffeensis strains in three divergent genetic groups, including Arkansas, Heartland, Jax, Liberty, Osceola, St. Vincent, Wakulla, and West Paces, and one Ehrlichia sp. HF strain.
Organism:
Ehrlichia sp. HF; Ixodes scapularis; Canis lupus familiaris; Ehrlichia chaffeensis str. Arkansas; Ehrlichia chaffeensis str. Jax; Ehrlichia chaffeensis str. Liberty; Ehrlichia chaffeensis str. Wakulla; Ehrlichia chaffeensis str. Heartland; Ehrlichia chaffeensis str. Osceola; Ehrlichia chaffeensis str. Saint Vincent; Ehrlichia chaffeensis str. West Paces
Type:
Expression profiling by high throughput sequencing
11 related Platforms
120 Samples
Download data: TXT
Series
Accession:
GSE56339
ID:
200056339
10.

Global gene transcription analysis of Anaplasma phagocytophilum in tick and human cells using tiling microarrays

(Submitter supplied) A whole genome tiling microarray based on the published sequence of the Anaplasma phagocytophilum (Ap) strain Hz genome was used to measure transcriptional activity of Ap grown to late stage in three cell lines representing the diversity of host cells naturally infected by Ap: two human cell lines, HL-60 (promyelocytic leukocyte) and HMEC-1 (microvascular endothelial), and the tick (Ixodes scapularis) cell line ISE6. more...
Organism:
Anaplasma phagocytophilum str. HZ; Ixodes scapularis; Homo sapiens
Type:
Expression profiling by genome tiling array
Platform:
GPL6869
18 Samples
Download data: CEL, TXT
Series
Accession:
GSE11487
ID:
200011487
11.

Evidence of the role of tick subolesin in gene expression

(Submitter supplied) Subolesin is an evolutionary conserved protein that was recently discovered in Ixodes scapularis as a tick protective antigen and has a role in tick blood digestion, reproduction and development. In other organisms, subolesin orthologs may be involved in the control of developmental processes. Because of the profound effect of subolesin knockdown in ticks and other organisms, we hypothesized that subolesin has a role in gene expression, thus affecting multiple cellular processes. more...
Organism:
Ixodes scapularis
Type:
Expression profiling by array
Platform:
GPL6394
4 Samples
Download data: GPR
Series
Accession:
GSE10222
ID:
200010222
12.

Illumina HiSeq 4000 (Ixodes scapularis)

Organism:
Ixodes scapularis
1 Series
12 Samples
Download data
Platform
Accession:
GPL30611
ID:
100030611
13.

Illumina NextSeq 500 (Ixodes pacificus)

Organism:
Ixodes pacificus
1 Series
18 Samples
Download data
Platform
Accession:
GPL30030
ID:
100030030
14.

Illumina HiSeq 2500 (Ixodes scapularis)

Organism:
Ixodes scapularis
1 Series
12 Samples
Download data
Platform
Accession:
GPL29893
ID:
100029893
15.

Illumina NextSeq 500 (Ixodes scapularis)

Organism:
Ixodes scapularis
1 Series
4 Samples
Download data
Platform
Accession:
GPL21603
ID:
100021603
16.

Illumina Genome Analyzer IIx (Ixodes ricinus)

Organism:
Ixodes ricinus
2 Series
10 Samples
Download data
Platform
Accession:
GPL21340
ID:
100021340
17.

Illumina Genome Analyzer II (Ixodes ricinus)

Organism:
Ixodes ricinus
1 Series
2 Samples
Download data
Platform
Accession:
GPL18567
ID:
100018567
18.

454 GS FLX (Ixodes ricinus)

Organism:
Ixodes ricinus
1 Series
1 Sample
Download data
Platform
Accession:
GPL18566
ID:
100018566
19.

Illumina HiSeq 2000 (Ixodes scapularis)

Organism:
Ixodes scapularis
3 Series
23 Samples
Download data
Platform
Accession:
GPL18496
ID:
100018496
20.

OSU subolesin dsRNA injected SSH library

(Submitter supplied) Total RNA was isolated from pooled guts and salivary glands of I. scapularis female ticks injected with subolesin dsRNA or injection buffer at 9 dpi (8 days of feeding) using TriReagent (Sigma) according to manufacturer’s instructions. SSH was performed at Evrogen JCS (Moscow, Russia) as described previously (Naranjo et al., 2006; de la Fuente et al., 2007b). Tester and driver RNAs were subtracted in both directions to construct two SSH libraries enriched for differentially expressed cDNAs in subolesin dsRNA-injected (reverse-subtracted) and saline-injected (forward-subtracted) ticks. more...
Organism:
Ixodes scapularis
1 Series
4 Samples
Download data
Platform
Accession:
GPL6394
ID:
100006394
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