GEO DataSets

(Submitter supplied) Progressive unfolding of gene expression cascades underlies diverse embryonic lineage development. Here, we report a single-cell RNA sequencing analysis of the complete and invariant embryonic cell lineage of the tunicate Ciona savignyi from fertilization to the onset of gastrulation. We reconstructed a developmental landscape of 47 cell types over eight cell cycles in the wild-type embryo and identified eight fate transformations upon fibroblast growth factor (FGF) inhibition. more...

Organism:

Ciona savignyi

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24946

56 Samples

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(Submitter supplied) DNA methylation has been found throughout animal kingdom, but it is still unclear whether this epigenetic mechanism affects the evolution of genomic elements in animals. Here, we compare the DNA methylomes of gametes and embryos from 7 representative animal species. We find that parental methylomes are propagated to the progeny without significant changes during embryogenesis in cnidarians and insects, but undergo substantial reprogramming in echinoderms, and the reprogramming become more dramatic during deuterostome evolution. more...

Organism:

Apis mellifera; Ciona savignyi; Nematostella vectensis; Strongylocentrotus purpuratus

Type:

Methylation profiling by high throughput sequencing

4 related Platforms

22 Samples

Download data: BED