GEO DataSets

(Submitter supplied) To comprehend the underlying mechanisms of NSC proliferation and differentiation, microRNA expression was investigated. Total RNA was extracted from NSCs, ESCs, and MEFs, and microRNA expression was examined using RT-PCR. This was accomplished utilizing the System Biosciences' Mouse miRNome Sanger miRVase microRNA Profiler Set.

Organism:

Mus musculus; Bordetella pertussis

Type:

Expression profiling by RT-PCR

Platform:

GPL29570

3 Samples

Download data: XLSX

(Submitter supplied) Bordetella pertussis has been shown to encode regulatory RNAs, yet the post-transcriptional regulatory circuits on which they act remain to be fully elucidated. We generated mutants lacking the endonucleases RNase III and RNase E and assessed their individual impact on the B. pertussis transcriptome. RNA-Seq analysis showed differential expression of ~25% of the B. pertussis transcriptome in each mutant with only 28% overlap between data sets. more...

Organism:

Bordetella pertussis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL29570

15 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Bordetella pertussis; Plasmodium falciparum; Chikungunya virus; Staphylococcus aureus; Onchocerca volvulus; Yellow fever virus; Streptococcus sp. 'group B'; Mycobacterium tuberculosis; Homo sapiens; Dengue virus; Human immunodeficiency virus; Respiratory syncytial virus; Zika virus

Type:

Protein profiling by protein array

Platform:

GPL29530

804 Samples

Download data

(Submitter supplied) Breastfeeding provides defense against infectious disease during early life. The mechanisms underlying this protection are complex but likely include the vast array of immune cells and components, such as immunoglobulins, in milk. Simply characterizing the concentrations of these bioactives, however, provides only limited information regarding their potential relationships with disease risk in the recipient infant. more...

Organism:

Bordetella pertussis; Mycobacterium tuberculosis; Plasmodium falciparum; Homo sapiens; Streptococcus sp. 'group B'; Onchocerca volvulus; Dengue virus; Human immunodeficiency virus; Respiratory syncytial virus; Zika virus; Staphylococcus aureus; Yellow fever virus; Chikungunya virus

Type:

Protein profiling by protein array

Platform:

GPL29530

402 Samples

Download data: TXT

(Submitter supplied) Breastfeeding provides defense against infectious disease during early life. The mechanisms underlying this protection are complex but likely include the vast array of immune cells and components, such as immunoglobulins, in milk. Simply characterizing the concentrations of these bioactives, however, provides only limited information regarding their potential relationships with disease risk in the recipient infant. more...

Organism:

Bordetella pertussis; Mycobacterium tuberculosis; Plasmodium falciparum; Homo sapiens; Respiratory syncytial virus; Yellow fever virus; Chikungunya virus; Staphylococcus aureus; Streptococcus sp. 'group B'; Onchocerca volvulus; Dengue virus; Human immunodeficiency virus; Zika virus

Type:

Protein profiling by protein array

Platform:

GPL29530

402 Samples

Download data: TXT

(Submitter supplied) Copper is both essential and toxic to living beings, which therefore tightly control its intracellular concentration. At the host-pathogen interface, copper is used by phagocytic cells to kill invading microorganisms. We investigated copper homeostasis in the whooping cough agent Bordetella pertussis, which lives in the human respiratory mucosa and has no environmental reservoir. B. pertussis has considerably streamlined copper homeostasis mechanisms relative to other Gram-negative bacteria. more...

Organism:

Bordetella pertussis; Bordetella bronchiseptica

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL28142 GPL27446

12 Samples

Download data: XLSX

(Submitter supplied) We examined the global transcription of B. pertussis in different strains and culture conditions

Organism:

Bordetella pertussis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27446

6 Samples

Download data: XLSX

(Submitter supplied) We examined the BvgA fixation on the genome of B. pertussis in different strains and culture conditions

Organism:

Bordetella pertussis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL27446

7 Samples

Download data: XLSX

(Submitter supplied) Bordetella pertussis is the causative agent of human whooping cough, a highly contagious respiratory disease which despite vaccination programs remains the major cause of infant morbidity and mortality. The requirement of the RNA chaperone Hfq for virulence of B. pertussis suggested that Hfq-dependent small regulatory RNAs are involved in the modulation of gene expression. High-throughput RNA sequencing revealed hundreds of putative noncoding RNAs including the RgtA sRNA. more...

Organism:

Bordetella pertussis

Type:

Expression profiling by array

Platform:

GPL19266

6 Samples

Download data: TXT

(Submitter supplied) Purpose: Within the past 20 years, outbreaks of whooping cough, caused by Bordetella pertussis, have led to respiratory disease and infant mortalities, despite good vaccination coverage. This is due at least in part to the introduction of a less effective acellular vaccine in the 1990’s. It is crucial then to understand the molecular basis of B. pertussis growth and infection. The two-component system BvgA/BvgS is the B. more...

Organism:

Bordetella pertussis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23369

8 Samples

Download data: XLSX

(Submitter supplied) Bordetella pertussis, the etiological agent of whooping cough, regulates the expression of its virulence factors by the well-defined BvgA/S two-component regulatory system. Phosphorylated BvgA activates the virulence activated genes (vags) and represses via the activation of the bvgR gene the expression of the virulence repressed genes (vrgs). In the presence of MgSO4, known as modulating condition, the BvgA/S system is inactive, and the vrgs are expressed. more...

Organism:

Bordetella pertussis

Type:

Expression profiling by array

Platform:

GPL19266

66 Samples

Download data: TXT

(Submitter supplied) Pertussis is a highly contagious, acute respiratory disease in humans caused by the Gram-negative pathogen Bordetella pertussis. Pertussis has resurged in the face of intensive vaccination and this has coincided with the emergence of strains carrying a particular allele for the pertussis toxin promoter, ptxP3, which is associated with higher levels of pertussis toxin (Ptx) production. Within 10 to 20 years, ptxP3 strains have nearly completely replaced the previously dominant ptxP1 strains resulting in a worldwide selective sweep. more...

Organism:

Bordetella pertussis B1917; Bordetella pertussis B1920; Bordetella bronchiseptica; Bordetella pertussis

Type:

Expression profiling by array

Platform:

GPL17516

24 Samples

Download data: PAIR

(Submitter supplied) Bordetella pertussis, the causative agent of whooping cough, produces a microcapsule at its surface but its role in pertussis pathogenesis remained to be investigated.Absence of KpsT, a membrane-associated protein involved in the polysaccharide transport resulted in the down-modulation of a large number of virulence genes which correlated with strong attenuation in vivo.

Organism:

Bordetella pertussis

Type:

Expression profiling by array

Platform:

GPL19266

6 Samples

Download data: TXT

(Submitter supplied) Resurgence of pertussis has been observed in many countries with high vaccination coverage and clonal expansion of certain Bordetella pertussis strains has been associated with recent epidemics in Europe. It is known that vaccinations have selected strains which are different from those used for vaccine production. However, little is known about the differences in genomic content of strains circulating before the vaccination was introduced. more...

Organism:

Bordetella pertussis

Type:

Genome variation profiling by array

Platform:

GPL5378

29 Samples

Download data

(Submitter supplied) Background Bordetella pertussis is a Gram-negative bacterium that infects the human respiratory tract and causes pertussis or whooping cough. The disease has resurged in many countries including Finland where the whole-cell pertussis vaccine has been used for more than 50 years. Antigenic divergence has been observed between vaccine strains and clinical isolates in Finland. To better understand genome evolution in B. more...

Organism:

Bordetella pertussis

Type:

Genome variation profiling by array

Platform:

GPL5378

26 Samples

Download data: TXT

(Submitter supplied) organism: Multiple pathogens Protocol: https://antigendiscovery.com/adi-proteome-microarray-technology/

Organism:

Bordetella pertussis; Staphylococcus aureus; Streptococcus sp. 'group B'; Mycobacterium tuberculosis; Plasmodium falciparum; Onchocerca volvulus; Yellow fever virus; Dengue virus; Human immunodeficiency virus; Respiratory syncytial virus; Chikungunya virus; Zika virus

3 Series

804 Samples

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(Submitter supplied) The NimbleGen array contained 1-8 probes for all coding sequences (CDS) with an average coverage of 7.5 probes per CDS and pseudogene, 15 bp overlapping tiling probes covering both strands of the intergenic regions, and 7,304 random probes with a similar length distribution and GC content as the experimental probes. The array design was based on the genome sequence of B. pertussis Tohama I, supplemented with additional B. more...

Organism:

Bordetella bronchiseptica; Bordetella pertussis

1 Series

24 Samples

Download data: NDF, NGD