txid550[Organism:exp] - GEO DataSets

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Select item 2002186141.

RNA-seq and mutagenesis analysis uncover the key mechanisms involved in polymyxin B resistance and heteroresistance in Enterobacter bugandensis

(Submitter supplied) To investigate the mechanism of PmB resistance and heteroresistance in Enterobacter bugandensis by analysing the differential gene expression under PmB treatment.

Organism:: Enterobacter cloacae

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32875
12 Samples

Download data: CSV

Series

Accession:: GSE218614

ID:: 200218614

Select item 2002457492.

TnpB homologs exapted from transposons are RNA-guided transcription factors

(Submitter supplied) Transposon-encoded tnpB and iscB genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination. These widespread gene families were repeatedly domesticated over evolutionary timescales, leading to the emergence of diverse CRISPR-associated nucleases including Cas9 and Cas12. We set out to test the hypothesis that TnpB nucleases may have also been repurposed for novel, unexpected functions other than CRISPR-Cas. more...

Organism:: Enterobacter cloacae; Escherichia coli; Enterobacter sp. BIDMC93

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other

4 related Platforms
51 Samples

Download data: BED, BW, XLSX

Series

Accession:: GSE245749

ID:: 200245749

Select item 2002361243.

Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response.

(Submitter supplied) Enterobacter cloacae is a Gram-negative nosocomial pathogen of the ESKAPE priority group with increasing multi-drug resistance via the acquisition of resistance plasmids. However, E. cloacae can also display phenotypic antimicrobial resistance, such as heteroresistance or persistence. Here we report that E. cloacae ATCC 13047 and six strains isolated from patients with blood infections display heteroresistance or persistence to aminoglycosides. more...

Organism:: Enterobacter cloacae subsp. cloacae ATCC 13047

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33540
9 Samples

Download data: CSV

Series

Accession:: GSE236124

ID:: 200236124

Select item 2002171484.

Genomic and Transcriptional Characterisation of Carbapenem and Colistin Resistance Mechanisms in Klebsiella pneumoniae

(Submitter supplied) The transcriptional, epigenomic, and genomic profiles of K. pneumoniae isolates were characterised to identify novel colistin and carbapenem resistance mechanisms. The genomic DNA and total RNA of the isolates were isolated and sequenced on PacBio.

Organism:: Enterobacter bugandensis; Enterobacter cloacae complex sp. R_G8; Acinetobacter baumannii; Enterobacter asburiae; Enterobacter cloacae; Klebsiella pneumoniae

Type:: Expression profiling by high throughput sequencing; Other

12 related Platforms
22 Samples

Download data: CSV, DIFF, GFF, PDF

Series

Accession:: GSE217148

ID:: 200217148

Select item 2002085735.

Molecular Epidemiology of Enterobacterales Resistant to Antibiotics of Last Resort in Pregnant Women in Labour at a Tertiary Hospital

(Submitter supplied) This study aims to determine the epidemiology of Enterobacteriaceae resistant to antibiotics of last resort in pregnant women in labour at a tertiary hospital, Pretoria, South Africa. Rectal swabs shall be used to screen for colonisation with CRE and colistin-resistant Enterobacteriales in pregnant women during labour. Carbapenem and colistin-resistant Enterobacterales can cause the following infections: bacteraemia; nosocomial pneumonia; urinary tract infections, and intra-abdominal infections. more...

Organism:: Enterobacter roggenkampii; Enterobacter cloacae; Klebsiella pneumoniae

Type:: Methylation profiling by high throughput sequencing; Other

Platforms:: GPL32493 GPL27625 GPL32492
5 Samples

Download data: GFF, XLSX

Series

Accession:: GSE208573

ID:: 200208573

Select item 2001278026.

Colistin heteroresistance in Enterobacter cloacae is regualted by PhoPQ-dependent 4-amino-4-deoxy-L arabinose addition to lipid A

(Submitter supplied) We report the transcriptional expression from wild type, ΔphoPQ, and ΔpmrAB to understand their contribution to colistin resistance.