GEO DataSets

(Submitter supplied) Transposon-encoded tnpB and iscB genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination. These widespread gene families were repeatedly domesticated over evolutionary timescales, leading to the emergence of diverse CRISPR-associated nucleases including Cas9 and Cas12. We set out to test the hypothesis that TnpB nucleases may have also been repurposed for novel, unexpected functions other than CRISPR-Cas. more...

Organism:

Escherichia coli; Enterobacter sp. BIDMC93; Enterobacter cloacae

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other

4 related Platforms

51 Samples

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(Submitter supplied) The transcriptional, epigenomic, and genomic profiles of K. pneumoniae isolates were characterised to identify novel colistin and carbapenem resistance mechanisms. The genomic DNA and total RNA of the isolates were isolated and sequenced on PacBio.

Organism:

Enterobacter cloacae; Klebsiella pneumoniae; Acinetobacter baumannii; Enterobacter asburiae; Enterobacter bugandensis; Enterobacter cloacae complex sp. R_G8

Type:

Expression profiling by high throughput sequencing; Other

12 related Platforms

22 Samples

Download data: CSV, DIFF, GFF, PDF

(Submitter supplied) This study aims to determine the epidemiology of Enterobacteriaceae resistant to antibiotics of last resort in pregnant women in labour at a tertiary hospital, Pretoria, South Africa. Rectal swabs shall be used to screen for colonisation with CRE and colistin-resistant Enterobacteriales in pregnant women during labour. Carbapenem and colistin-resistant Enterobacterales can cause the following infections: bacteraemia; nosocomial pneumonia; urinary tract infections, and intra-abdominal infections. more...

Organism:

Enterobacter cloacae; Klebsiella pneumoniae; Enterobacter roggenkampii

Type:

Methylation profiling by high throughput sequencing; Other

Platforms:

GPL27625 GPL32492 GPL32493

5 Samples

Download data: GFF, XLSX