Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 178

1.

Differential Gene expression anslysis between artesunate sensitive and resistat Leishmania donovani

(Submitter supplied) Gene expression analysis was carried out between experimental artesunate resistant Leishmania donovani (adapted to 50 µM artesunate drug pressure) and it's corresponding wild type artesunate sensitive parasite.
Organism:
Leishmania donovani
Type:
Expression profiling by array
Platform:
GPL25446
6 Samples
Download data: TXT
Series
Accession:
GSE118460
ID:
200118460
2.

Differential gene expression analysis in clinical isolate of Leishmania donovani .

(Submitter supplied) Differential gene expression analysis was carried out in clinical isolates of Leishmania donovani (L. donovani) parasite derived from VL patient before miltefosine treatment, post treatment and patient that relpased after miltefosine treatment
Organism:
Leishmania; Leishmania donovani
Type:
Expression profiling by array
Platform:
GPL13919
16 Samples
Download data: TXT
Series
Accession:
GSE107262
ID:
200107262
3.

Functional and Technical Validation of SL-seq, a method for RNA-seq in Trypanosomatids

(Submitter supplied) We developed a novel method for RNA-seq in Trypanosomatids called ‘Spliced-Leader Sequencing’ (SL-seq). The method is based on the fact that the 5’ end of Trypanosomatid mRNA is starts with a SL-sequence, and specifically enriches SL-containing RNA prior to sequencing. In this study we compared the performance and functional results obtained with SL-seq to those generated with conventional Illumina Stranded mRNA prep. more...
Organism:
Homo sapiens; Leishmania donovani
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL23109 GPL23108 GPL23110
37 Samples
Download data: TXT
Series
Accession:
GSE95353
ID:
200095353
4.

RNA Analysis for Modulation of aneuploidy in Leishmania donovani during adaptation to different in vitro and in vivo environments, and its impact on gene expression

(Submitter supplied) Purpose: Monitor modulation of aneuploidy in Leishmania donovani during adaptation to different in vitro and in vivo environments, and its impact on gene expression Importance: Aneuploidy is usually detrimental in multicellular organisms, but in several micro-organisms (fungi being the best-studied) it can be tolerated and even beneficial. Leishmania – a protozoan parasite killing more than 30,000 persons each year – is emerging as a new model for aneuploidy studies: unexpectedly high levels of aneuploidy are found in clinical isolates. more...
Organism:
Leishmania donovani
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23261
11 Samples
Download data: TXT
Series
Accession:
GSE97453
ID:
200097453
5.

Genome-wide mapping of 5-hydroxymethyluracil in eukaryote parasite Leishmania

(Submitter supplied) 5-hydroxymethyluracil (5hmU) is a thymine base modification found in genomes of a diverse range of organisms. To explore the functional importance of 5hmU, we developed a method for the genome-wide mapping of 5hmU-modified loci based on a chemical tagging strategy for the hydroxymethyl group. We applied the method to generate genome-wide maps of 5hmU in parasitic protozoan Leishmania, where 5hmU forms enzymatically via hydroxylation of thymine. more...
Organism:
Leishmania donovani; Leishmania major
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing
Platforms:
GPL22015 GPL22014
24 Samples
Download data: TXT
6.

Differential Gene expression anslysis between Paromomycin sensitive and resistat Leishmania donovani.

(Submitter supplied) Gene expression analysis was carried out between experimental Paromomycin resistant Leishmania donovani (adapted to 100 µM paromomycin drug pressure) and it's corresponding wild type paromomycin sensitive parasite.
Organism:
Leishmania; Leishmania donovani
Type:
Expression profiling by array
Platform:
GPL13919
6 Samples
Download data: TXT
Series
Accession:
GSE74208
ID:
200074208
7.

An arginine sensing pathway in Leishmania induces a Mitogen-Activated Protein Kinase 2-mediated response during macrophage invasion

(Submitter supplied) Protozoa of the genus Leishmania are the causative agents of leishmaniasis in humans. These parasites cycle between promastigotes in the sand fly mid-gut and amastigotes in phagolysosome of mammalian macrophages. During infection, host up-regulate nitric oxide synthase and parasite induce host arginase expression, both of which use arginine as a substrate. These elevated activities deplete macrophage arginine pools, a situation that invading Leishmania must overcome since it is an essential amino acid. more...
Organism:
Leishmania donovani
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17379
10 Samples
Download data: TAB
Series
Accession:
GSE71572
ID:
200071572
8.

Comparative analysis of gene expression in HAT4-nulls and HAT2-heterozygous knockout cells, versus wild type Leishmania donovani cells

(Submitter supplied) Histone acetylations are known to impact gene transcription. Here, we have attempted to examine the role of Leishmania donovani histone acetyltransferases HAT4 and HAT2 in regulating global gene expression. The transcriptome of HAT4-null promastigotes (Samples 2A, 2B) and HAT2-heterozygous knockout promastigotes (Samples 3A, 3B) have been compared with the transcriptome of wild-type Leishmania promastigotes (Samples 1A, 1B) and fold change in gene expression with respect to the control wild-type has been determined.
Organism:
Leishmania donovani
Type:
Expression profiling by array
Platform:
GPL18125
6 Samples
Download data: TXT, XLS
Series
Accession:
GSE76574
ID:
200076574
9.

Overall gene expression comparison between antimony resistant and sensitive Leishmania donovani

(Submitter supplied) The mRNA expression of antimony resistant strains of Leishmania donovani was compared to the expression of the sensitive Leishmania donovani.
Organism:
Leishmania donovani
Type:
Expression profiling by array
Platform:
GPL19308
8 Samples
Download data: TXT
Series
Accession:
GSE62468
ID:
200062468
10.

Metabolic Reprogramming During Purine Stress in the Protozoan Pathogen Leishmania donovani

(Submitter supplied) The ability of Leishmania to survive in their insect or mammalian host is dependent upon an ability to sense and adapt to changes in the microenvironment. However, little is known about the molecular mechanisms underlying the parasite response to environmental changes, such as nutrient availability. To elucidate nutrient stress response pathways in Leishmania donovani, we have used purine starvation as the paradigm. more...
Organism:
Leishmania donovani
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17379
2 Samples
Download data: TXT, XLSX
Series
Accession:
GSE48394
ID:
200048394
11.

Identification of biomarkers for Miltefosine resistance in Leishmania donovani

(Submitter supplied) To identify biomarkers specific for Miltefosin resistant parasites, we used DNA microarray to identify differentially expressed genes in resistant parasite in comparision to sensitive and further validated with real time PCR assay and immunoblotting assay
Organism:
Leishmania donovani
Type:
Expression profiling by array
Platform:
GPL18125
4 Samples
Download data: TXT
Series
Accession:
GSE53738
ID:
200053738
12.

Examining the genetic basis for visceral leishmaniasis disease: Comparison of distinct Leishmania donovani isolates that cause cutaneous and visceral leishmaniasis in Sri Lanka

(Submitter supplied) Among the most central questions in Leishmania research is why some species remain in the skin dermis at the site of infection by the sand fly vector whereas other species migrate to visceral organs where they cause fatal visceral leishmaniasis. Although L. donovani is the species typically responsible for visceral leishmaniasis, an atypical L. donovani strain is the etiologic agent for cutaneous leishmaniasis in Sri Lanka. more...
Organism:
Leishmania donovani
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL17379
6 Samples
Download data: TXT
13.

Comparison of gene expression of miltefosine responsive Vs miltefosine unresponsive Leishmania donovani promastigotes

(Submitter supplied) The current study aims to study change in gene expression profile of miltefosine resistance L. donovani with respect to miltefosine responsive L. donovani.
Organism:
Leishmania donovani
Type:
Expression profiling by array
Platform:
GPL16867
4 Samples
Download data: TXT
Series
Accession:
GSE45496
ID:
200045496
14.

Leishmania donovani amastigotes: Nelfinavir (NFV)-sensitive (control) vs Nelfinavir-resistant

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Leishmania donovani; Leishmania
Type:
Genome variation profiling by array; Expression profiling by array
Platform:
GPL11330
6 Samples
Download data: TXT
Series
Accession:
GSE42197
ID:
200042197
15.

Leishmania donovani amastigotes: Nelfinavir (NFV)-sensitive (control) vs Nelfinavir-resistant [RNA expression profiling]

(Submitter supplied) Drug resistance is a major public health challenge in Leishmaniasis chemotherapy, particularly in the case of emerging Leishmania/HIV-1 co-infections. Recently, we have delineated the mechanism of cell death induced by the HIV-1 protease inhibitor, Nelfinavir, in the Leishmania parasite. In order to investigate the underlying molecular mechanism involved in Nelfinavir resistance, in vitro Nelfinavir resistant amastigotes were developed by direct drug pressure in culture. more...
Organism:
Leishmania donovani; Leishmania
Type:
Expression profiling by array
Platform:
GPL11330
3 Samples
Download data: TXT
Series
Accession:
GSE42196
ID:
200042196
16.

Leishmania donovani amastigotes: Nelfinavir (NFV)-sensitive (control) vs Nelfinavir-resistant [Comparative Genomic Hybridization (DNA) profiling]

(Submitter supplied) Drug resistance is a major public health challenge in Leishmaniasis chemotherapy, particularly in the case of emerging Leishmania/HIV-1 co-infections. Recently, we have delineated the mechanism of cell death induced by the HIV-1 protease inhibitor, Nelfinavir, in the Leishmania parasite. In order to investigate the underlying molecular mechanism involved in Nelfinavir resistance, in vitro Nelfinavir resistant amastigotes were developed by direct drug pressure in culture. more...
Organism:
Leishmania donovani; Leishmania
Type:
Genome variation profiling by array
Platform:
GPL11330
3 Samples
Download data: TXT
Series
Accession:
GSE42195
ID:
200042195
17.

Differential gene expression analysis between Miltefosine resistant and sensitive leishmania donovani

(Submitter supplied) Gene expression analysis was carried out between experimental miltefosine resistant L.donovani (adapted to 30ug/ml miltefosine drug pressure) and its corresponding wild type miltefosine senstive parasite
Organism:
Leishmania; Leishmania donovani
Type:
Expression profiling by array
Platform:
GPL13919
6 Samples
Download data: TXT
Series
Accession:
GSE30685
ID:
200030685
18.

Multiple levels of gene regulation mediate differentiation of the intracellular pathogen Leishmania

(Submitter supplied) Whole genome high density tiliing array of eight timepoints from the promastitgote to amastigote differentiation process.
Organism:
Leishmania donovani; Leishmania infantum JPCM5
Type:
Expression profiling by array
Platform:
GPL10446
16 Samples
Download data: TXT
Series
Accession:
GSE21936
ID:
200021936
19.

The expression profiles of promastigotes and axenic amastigotes in Leishmania donovani

(Submitter supplied) In this study, we examined the transcriptome of Leishmania donovani promastigotes and axenic amastigotes to identify differentially regulated mRNAs utilizing the serial analysis of gene expression Keywords: stage differentiation; axenic amastigotes
Organism:
Leishmania donovani
Type:
Expression profiling by SAGE
Platform:
GPL3252
2 Samples
Download data
Series
Accession:
GSE3835
ID:
200003835
20.

Agilent Custom L.donovani Expression 8x15k Array (AMADID: 027511) designed by Genotypic Technology Private Limited

(Submitter supplied) www.chem.agilent.com
Organism:
Leishmania donovani
1 Series
6 Samples
Download data
Platform
Accession:
GPL25446
ID:
100025446
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=txid5661[Organism:exp]|query=1|qty=6|blobid=NCID_1_183604484_130.14.22.33_9001_1568719837_1683397873_0MetA0_S_MegaStore_F_1|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center