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Items: 1 to 20 of 1340

1.

A non-ribosomal peptide pheromone controls male-induced female sexual development in Schistosoma mansoni

(Submitter supplied) gli1 is a gene in the male S. mansoni required for female sexual development. As a putative transcription factor, RNAseq comparing pairs with gli1 knocked-down or control males was performed to look for the genes which are trancriptionally regulated by gli1. sm-nrps was one of the essential candidate discovered in this analysis that has been characterized in the same publication, revealing a pheromone directed novel mechanism of female schistosome sexual development.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28252
24 Samples
Download data: CSV
Series
Accession:
GSE184849
ID:
200184849
2.

Characterization of schistosomal microRNA by species, sex and developmental stage

(Submitter supplied) To date, 115 miRNAs genes (precursors) have been registered in miRBase for Schistosoma mansoni, and 56 for Schistosoma japonicum (225 and 79 mature miRNA, respectively). miRNAs have not been systematically described in Schistosoma haematobium. Our aim in this study was to systematically characterize and quantify miRNA in Schistosoma by species, developmental stage and sex and to test the usefulness of this characterization in biomarker discovery for infection. more...
Organism:
Schistosoma mansoni; Schistosoma haematobium; Schistosoma japonicum
Type:
Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL21570 GPL25265 GPL25263
60 Samples
Download data: TXT
Series
Accession:
GSE116546
ID:
200116546
3.

Single-cell analysis reveals regulation of germline stem cell fate in the human parasite Schistosoma mansoni

(Submitter supplied) Schistosomes are parasitic flatworms that cause one of the most prevalent infectious diseases from which millions of people are currently suffering. Here, we construct a cell type atlas of juvenile schistosomes to capture germline stem cells (GSCs) in the course of de novo gonadal development.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26379
29 Samples
Download data: TSV, TXT
Series
Accession:
GSE147355
ID:
200147355
4.

A single-cell RNA-seq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24248 GPL28252
15 Samples
Download data
Series
Accession:
GSE146737
ID:
200146737
5.

A single-cell RNA-seq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding [scRNA-Seq]

(Submitter supplied) In order to better understand the biology of adult schistosomes, we performed single-cell RNAseq on adult male, adult sexually-mature female, and adult virgin female parasites.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24248
9 Samples
Download data: RDS, XLSX
Series
Accession:
GSE146736
ID:
200146736
6.

A single-cell RNA-seq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding [RNA-Seq]

(Submitter supplied) The schistosome homolog of hnf4 is involved in parasite blood feeding and stem cell biology. In order to understand the function of hnf4, we performed RNAseq on either control(RNAi) or hnf4(RNAi) parasites to see the transcriptional consequences of hnf4 RNAi
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28252
6 Samples
Download data: CSV
Series
Accession:
GSE146735
ID:
200146735
7.

Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni

(Submitter supplied) stk25 and tao genes came out of an RNAi screen in the parasitic flatworm Schistosoma mansoni, and these genes shared a similar knockdown phenotype. To test for a functional relationship, we compared transcriptomes of early knockdown worms for each gene, compared to mock controls.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28252
12 Samples
Download data: XLSX
Series
Accession:
GSE146720
ID:
200146720
8.

Transcriptomic analysis of reduced sensitivity to praziquantel in Schistosoma mansoni

(Submitter supplied) Schistosomiasis is a chronic neglected tropical disease caused by digenetic parasitic flatworms of the genus Schistosoma. The disease is estimated to affect over 206 million people, the majority of whom live in Africa where Schistosoma mansoni and Schistosoma japonicum are the major causative agents. While a number of drugs have been used to treat schistosomiasis, praziquantel (PZQ) is the only one that is widely available, relatively cheap, and easy to use. more...
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24248
24 Samples
Download data: XLSX
Series
Accession:
GSE120682
ID:
200120682
9.

Single-cell RNA sequencing of proliferative stem cell population from juvenile Schistosoma mansoni worms

(Submitter supplied) The rise of single-cell RNA sequencing (scRNAseq) technologies has enabled researchers to classify cell types, delineate cell developmental trajectories, and measure molecular responses to external perturbations. These technologies all rely on the premise that cell-to-cell variations arising from the biological processes of interest are clearly distinguishable from the intrinsic transcriptional and technical noise. more...
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL26379 GPL24248
737 Samples
Download data: CSV, FA, TXT
Series
Accession:
GSE116920
ID:
200116920
10.

Transcriptional Profiling of Schistosoma mansoni f zfp-1-1(RNAi) parasites

(Submitter supplied) We distrupted the expression of the Schistosoma mansoni zfp-1-1 gene using RNA interference and examined the transcriptional effects by illumina sequencing
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24248
6 Samples
Download data: XLSX
Series
Accession:
GSE106693
ID:
200106693
11.

Schistosomula exposed to HDAC inhibitor (Trichostatin A)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL22001
18 Samples
Download data: TXT
Series
Accession:
GSE83211
ID:
200083211
12.

Schistosomula exposed to HDAC inhibitor (Trichostatin A) [48hrs]

(Submitter supplied) HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL22001
6 Samples
Download data: TXT
Series
Accession:
GSE83210
ID:
200083210
13.

Schistosomula exposed to HDAC inhibitor (Trichostatin A) [24hrs]

(Submitter supplied) HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL22001
6 Samples
Download data: TXT
Series
Accession:
GSE83209
ID:
200083209
14.

Schistosomula exposed to HDAC inhibitor (Trichostatin A) [12hrs]

(Submitter supplied) HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL22001
6 Samples
Download data: TXT
Series
Accession:
GSE83208
ID:
200083208
15.

A comprehensive 30K microarray platform to test transcriptomic responses in Biomphalaria glabrata

(Submitter supplied) Transcriptional profiling of Biomphalaria snail (whole body tissues) comparing BS90 strain untreated with sterile wounding and septic injury using a new comprehensive microarray platform design. Goal was to compare responses to differen immune challenges within one strain.
Organism:
Schistosoma mansoni; Echinostoma paraensei; Biomphalaria glabrata
Type:
Expression profiling by array
Platform:
GPL20708
7 Samples
Download data: TXT
Series
Accession:
GSE71054
ID:
200071054
16.

Comparison of gene expression between female Schistosoma mansoni heads and tails

(Submitter supplied) We report differences in gene expression between the anterior and posterior of female Schistosoma mansoni parasites
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21570
6 Samples
Download data: XLSX
Series
Accession:
GSE78967
ID:
200078967
17.

Stem cells rejuvinate the schistosome host-parasite interface

(Submitter supplied) We report the transcriptional effects of long-term stem cell depletion in Schistosoma mansoni
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15914
14 Samples
Download data: XLS
Series
Accession:
GSE75861
ID:
200075861
18.

Functional Networks Of Praziquantel-Induced Differentially Expressed Genes In Schistosoma mansoni And Synergy Of Omeprazole And Praziquantel In Vitro Against Adult Worms

(Submitter supplied) Background: Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Therefore, there is a pressing need to explore the effects of PZQ on the parasites at the molecular level and to pursue alternative and/or or synergistic drugs against schistosomiasis. Methodology: We used a custom-designed Schistosoma mansoni oligo-microarray to explore the effects of a sublethal dose of praziquantel on S. more...
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL8606
12 Samples
Download data: TXT
Series
Accession:
GSE66697
ID:
200066697
19.

Effect of MG132 on expression profile of Schistosoma mansoni adult worms

(Submitter supplied) Transcriptional profiling of MG132 treated S. mansoni adult worms (50uM of MG132 in DMSO during 24h) vs. Non-treated S.mansoni adult worms (DMSO during 24h) Two conditions (treated vs. Non-treated) with four biological samples of treated worms (MG132 1, 2, 3 and 4) and four biological samples of non-treated worms (Control 1, 2, 3 and 4). For each sample (four treated and four non-treated) were performed two technical replicas.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL18703
8 Samples
Download data: TXT
Series
Accession:
GSE57722
ID:
200057722
20.

Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects

(Submitter supplied) Transcriptional profiling of Imatinib-treated paired adult S. mansoni vs. Non-treated (control) paired adult S. mansoni during 24 and 48 hours
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL8606
12 Samples
Download data: TXT
Series
Accession:
GSE53154
ID:
200053154
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