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Items: 1 to 20 of 24157

1.

Genome-wide expression analysis of C. elegans nematodes overexpressing the transcription factor grh-1

(Submitter supplied) We report identification of possible GRH-1 target genes in C. elegans, by analyzing changes in overall transcriptome following stable overexpression of this transcription factor.
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13657
6 Samples
Download data
Series
Accession:
GSE159077
ID:
200159077
2.

Neuronal HSF-1 activity coordinates fat desaturation across tissues in C. elegans via TGF-b/BMP signalling

(Submitter supplied) To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process that has been previously described to be cell-autonomous. We have discovered that, in Caenorhabditis elegans, the neuronal over-expression of the master regulator of the conserved heat shock response (HSR), Hsf-1, causes extensive fat remodelling in peripheral tissues. These changes include a decrease in fat desaturase expression in the gut, and a shift in the saturation levels of fatty acids in the plasma membrane, in line with ectothermic adaptive responses. We have identified the cGMP receptor TAX-2/TAX-4 and TGF-β/BMP signalling, as key players in signalling across tissues. We also find that gradual increments in ambient temperature result in HSR activation exclusively in wild-type head neurons. This is the first study to suggest that a thermostat-based mechanism can non-cell autonomously coordinate membrane fluidity in response to warm temperatures across tissues in multicellular animals.
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
6 Samples
Download data: XLSX
Series
Accession:
GSE145123
ID:
200145123
3.

Sequencing of Caenorhabditis elegans at two different time points after Rotenone and DMSO treatment (smallRNA)

(Submitter supplied) Comparison of small RNA expression profiles from C. elegans of Rotenone and Dimethylsulfoxid (DMSO) treated animals. The RNA-seq data comprise two age groups (5 and 15 days) and two different conditions (rotenone, DMSO). Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL18245
12 Samples
Download data: XLS
Series
Accession:
GSE110849
ID:
200110849
4.

Sequencing of Caenorhabditis elegans at 4 different time points after Rotenone and DMSO treatment (small RNA)

(Submitter supplied) Comparison of small RNA expression profiles from C. elegans after Rotenone and Dimethylsulfoxid (DMSO) treatment. The RNA-seq data comprise 4 age groups (1, 5, 10 and 20 days) and two different treatments (Rotenone and DMSO). Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL13657
22 Samples
Download data: XLS
Series
Accession:
GSE110848
ID:
200110848
5.

Sequencing of Caenorhabditis elegans at 4 different time points

(Submitter supplied) small RNA gene expression profiles of C. elegans in 4 age groups. The RNA-seq data comprise 4 age groups (1, 5, 10 and 20 days after L4). Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL13657
11 Samples
Download data: XLS
Series
Accession:
GSE110847
ID:
200110847
6.

Sequencing of Caenorhabditis elegans at 5 different time point after Rotenone and DMSO treatment (smallRNA)

(Submitter supplied) Comparison of small RNA expression profiles from C. elegans at different time points after Rotenone and Dimethylsulfoxid (DMSO) treatment. The RNA-seq data comprise 5 time points (6 hours, 1, 2, 3 and 5 days) treated with Rotenone and DMSO as well as 2 time points (3 and 5 days) with an additional H2O treatment. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL18245
36 Samples
Download data: XLS
Series
Accession:
GSE110846
ID:
200110846
7.

Sequencing of endogenous mRNA from Caenorhabditis elegans at two time points in the presence and absence of arsenite

(Submitter supplied) Background: Arsenite is one of the most toxic chemical substances known and is assumed to exert detrimental effects on viability even at lowest concentrations. By contrast and unlike higher concentrations, we here find that exposure to low-dose arsenite promotes growth of cultured mammalian cells. In the nematode C. elegans, low-dose arsenite promotes resistance against thermal and chemical stressors, and extends lifespan of this metazoan, whereas higher concentrations reduce longevity. more...
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13776
8 Samples
Download data: XLS
Series
Accession:
GSE110845
ID:
200110845
8.

Gene expression profiling to study the influence of OP50 diet on lifespan of C. elegans.

(Submitter supplied) Transcriptome profiling of C. elegans wildtype strain (N2) fed heat-inactivated OP50 diet for 5 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13776
2 Samples
Download data: XLS
Series
Accession:
GSE110844
ID:
200110844
9.

Sequencing of Caenorhabditis elegans at two different time points after Rotenone and DMSO treatment (mRNA)

(Submitter supplied) Comparison of gene expression profiles from C. elegans of Rotenone and Dimethylsulfoxid (DMSO) treated animals. The RNA-seq data comprise two age groups (5 and 15 days) and two different conditions (rotenone, DMSO). Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
12 Samples
Download data: XLS
Series
Accession:
GSE110843
ID:
200110843
10.

Sequencing of Caenorhabditis elegans overexpression mutants.

(Submitter supplied) Comparison of gene expression profiles from C. elegans mutant strains (MIR73, MIR75 or MIR77) overexpressing genes involved in proline metabolism (B0513.5 or T22H6.2) with wildtype strain (N2) at 5 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
12 Samples
Download data: XLS
Series
Accession:
GSE110842
ID:
200110842
11.

Sequencing of Caenorhabditis elegans wildtype strain (N2) treated with T25B9.1 RNAi for 2 and 5 days after L4 larvae stage.

(Submitter supplied) Comparison of gene expression profiles from C. elegans wildtype strain (N2) treated with L4440 and T25B9.1 RNAi for 2 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
6 Samples
Download data: XLS
Series
Accession:
GSE110841
ID:
200110841
12.

Sequencing of Caenorhabditis elegans deletion mutants treated with RNAi

(Submitter supplied) Comparison of gene expression profiles from C. elegans mutant strain CF1038 treated with L4440 and K02A4.1 RNAi and C. elegans mutant strain TU3311 treated with L4440 and B0412.2 RNAi for 5 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
12 Samples
Download data: XLS
Series
Accession:
GSE110840
ID:
200110840
13.

Sequencing of Caenorhabditis elegans treated with L4440 and 6B3B.9

(Submitter supplied) Comparison of gene expression profiles from C. elegans treated with L4440 and 6B3B.9. The RNA-seq data comprise two groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
6 Samples
Download data: XLS
Series
Accession:
GSE110839
ID:
200110839
14.

Sequencing of Caenorhabditis elegans after 9 different RNAi treatments

(Submitter supplied) Comparison of gene expression profiles from C. elegans treated with 9 different RNAis. The RNA-seq data comprise 9 groups (C01A2.5, F25H2.5, F26D12.1, F55H2.6, L4440, M04C9.5, R04E5.10, R186.7, ZK795.1) Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
30 Samples
Download data: XLS
Series
Accession:
GSE110838
ID:
200110838
15.

Sequencing of Caenorhabditis elegans treated with 3 different RNAi.

(Submitter supplied) Comparison of gene expression profiles from C. elegans treated with L4440, B0395.3 and H28O16.1. The RNA-seq data comprise three groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
9 Samples
Download data: XLS
Series
Accession:
GSE110837
ID:
200110837
16.

Sequencing of Caenorhabditis elegans at 3 time points treated with RNAi.

(Submitter supplied) Comparison of gene expression profiles from C. elegans treated with RNAis. (L4440, prp-19, skp-1) at different time points (1, 5 and 10 days). The RNA-seq data comprise 9 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
36 Samples
Download data: XLS
Series
Accession:
GSE110836
ID:
200110836
17.

Sequencing of Caenorhabditis elegans treated with L4440, M05B5.3 and T14F9.5 at two different time points

(Submitter supplied) Comparison of gene expression profiles from C. elegans treated with L4440, M05B5.3 and T14F9.5. The RNA-seq data comprise two age groups (1 and 5 days) and 3 different RNAi treatments (L4440, M05B5.5, T14F9.5). Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
18 Samples
Download data: XLS
Series
Accession:
GSE110835
ID:
200110835
18.

Sequencing of Caenorhabditis elegans at 5 different time point after Rotenone and DMSO treatment (mRNA)

(Submitter supplied) Comparison of gene expression profiles from C. elegans at different time points after Rotenone and Dimethylsulfoxid (DMSO) treatment. The RNA-seq data comprise 5 time points (6 hours, 1, 2, 3 and 5 days) treated with Rotenone and DMSO as well as 2 time points (3 and 5 days) with an additional H2O treatment. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
36 Samples
Download data: XLS
Series
Accession:
GSE110834
ID:
200110834
19.

Sequencing of C.elegans at different time points treated with bcat-1 RNAi and controls

(Submitter supplied) Comparison of gene expression profiles of C. elegans treated with bcat-1 RNAi Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
12 Samples
Download data: XLS
Series
Accession:
GSE110833
ID:
200110833
20.

daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71

(Submitter supplied) Many tissue-specific stem cells maintain the ability to produce multiple cell types during long periods of non-division, or quiescence. FOXO transcription factors promote quiescence and stem cell maintenance, but the mechanisms by which FOXO proteins promote multipotency during quiescence are still emerging. The single FOXO ortholog in C. elegans, daf-16, promotes entry into a quiescent and stress-resistant larval stage called dauer in response to adverse environmental cues. more...
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18245
6 Samples
Download data: TXT
Series
Accession:
GSE179166
ID:
200179166
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